SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4da5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		3 / 3 GLU A 227
ILE A 224
ARG A 212
 None
 0.78A 1cd2A-4da5A:
undetectable		 1cd2A-4da5A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 CYH A 303
ASP A 342
VAL A 301
GLY A 340
 None
 1.25A 1ekjC-4da5A:
undetectable
1ekjD-4da5A:
undetectable		 1ekjC-4da5A:
17.58
1ekjD-4da5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 CYH A 303
ASP A 342
VAL A 301
GLY A 340
 None
 1.23A 1ekjC-4da5A:
undetectable
1ekjD-4da5A:
undetectable		 1ekjC-4da5A:
17.58
1ekjD-4da5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 8 HIS A 304
ASP A 342
SER A 335
THR A 252
 None
 1.22A 1p7lC-4da5A:
undetectable		 1p7lC-4da5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 8 HIS A 304
ASP A 342
SER A 335
THR A 252
 None
 1.21A 1p7lD-4da5A:
undetectable		 1p7lD-4da5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 8 HIS A 304
ASP A 342
SER A 335
THR A 252
 None
 1.20A 1rg9A-4da5A:
undetectable		 1rg9A-4da5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 8 HIS A 304
ASP A 342
SER A 335
THR A 252
ASP A 306
 None
None
None
None
0H7  A 502 (-3.1A)
 1.35A 1rg9B-4da5A:
undetectable		 1rg9B-4da5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 8 HIS A 304
ASP A 342
SER A 335
THR A 252
 None
 1.21A 1rg9C-4da5A:
undetectable		 1rg9C-4da5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 8 HIS A 304
ASP A 342
SER A 335
THR A 252
 None
 1.20A 1rg9D-4da5A:
undetectable		 1rg9D-4da5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		3 / 3 ARG A 367
SER A 355
TYR A 354
 None
None
0H7  A 502 (-3.5A)
 0.60A 1x70A-4da5A:
2.4		 1x70A-4da5A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 10 ALA A  91
LEU A 145
TRP A 103
PHE A 111
LEU A 205
 None
 1.31A 1y7iB-4da5A:
undetectable		 1y7iB-4da5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MES_A_DMEA427_1
(CHOLINE KINASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		7 / 10 ASP A 306
GLU A 349
TYR A 354
TRP A 420
TRP A 423
PHE A 435
TYR A 440
 0H7  A 502 (-3.1A)
0H7  A 502 (-4.4A)
0H7  A 502 (-3.5A)
0H7  A 502 (-3.6A)
0H7  A 502 (-4.1A)
0H7  A 502 ( 3.6A)
0H7  A 502 (-4.9A)
 0.39A 3mesA-4da5A:
35.7		 3mesA-4da5A:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MES_A_DMEA427_1
(CHOLINE KINASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		7 / 10 GLN A 308
GLU A 349
TYR A 354
TRP A 420
TRP A 423
PHE A 435
TYR A 440
 0H7  A 502 (-3.1A)
0H7  A 502 (-4.4A)
0H7  A 502 (-3.5A)
0H7  A 502 (-3.6A)
0H7  A 502 (-4.1A)
0H7  A 502 ( 3.6A)
0H7  A 502 (-4.9A)
 0.54A 3mesA-4da5A:
35.7		 3mesA-4da5A:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MES_B_DMEB427_1
(CHOLINE KINASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		7 / 10 ASP A 306
GLU A 349
TYR A 354
TRP A 420
TRP A 423
PHE A 435
TYR A 440
 0H7  A 502 (-3.1A)
0H7  A 502 (-4.4A)
0H7  A 502 (-3.5A)
0H7  A 502 (-3.6A)
0H7  A 502 (-4.1A)
0H7  A 502 ( 3.6A)
0H7  A 502 (-4.9A)
 0.40A 3mesB-4da5A:
35.8		 3mesB-4da5A:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MES_B_DMEB427_1
(CHOLINE KINASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		7 / 10 GLN A 308
GLU A 349
TYR A 354
TRP A 420
TRP A 423
PHE A 435
TYR A 440
 0H7  A 502 (-3.1A)
0H7  A 502 (-4.4A)
0H7  A 502 (-3.5A)
0H7  A 502 (-3.6A)
0H7  A 502 (-4.1A)
0H7  A 502 ( 3.6A)
0H7  A 502 (-4.9A)
 0.54A 3mesB-4da5A:
35.8		 3mesB-4da5A:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		3 / 3 TYR A 280
ASP A 446
ASP A 439
 None
 0.82A 4a6eA-4da5A:
undetectable		 4a6eA-4da5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 10 PRO A 194
ILE A 209
LEU A 313
ILE A 329
ASP A 330
 None
 1.04A 4dt8B-4da5A:
15.8		 4dt8B-4da5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 10 PRO A 194
ILE A 209
LEU A 313
ILE A 329
ASP A 330
 None
 1.04A 4dtaA-4da5A:
5.3		 4dtaA-4da5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 8 ASP A 342
PHE A 378
LEU A 328
HIS A 236
 None
 1.18A 4f5zA-4da5A:
undetectable		 4f5zA-4da5A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
 None
None
0H7  A 502 (-3.1A)
0H7  A 502 (-3.1A)
None
 0.99A 4uroA-4da5A:
undetectable		 4uroA-4da5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
 None
None
0H7  A 502 (-3.1A)
0H7  A 502 (-3.1A)
None
 1.13A 4uroB-4da5A:
undetectable		 4uroB-4da5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
 None
None
0H7  A 502 (-3.1A)
0H7  A 502 (-3.1A)
None
 1.06A 4uroC-4da5A:
undetectable		 4uroC-4da5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
0H7  A 502 (-3.1A)
None
None
 1.03A 4w5qA-4da5A:
undetectable		 4w5qA-4da5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
0H7  A 502 (-3.1A)
None
None
 1.07A 4w5tA-4da5A:
undetectable		 4w5tA-4da5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
0H7  A 502 (-3.1A)
None
None
 1.14A 4z4dA-4da5A:
undetectable		 4z4dA-4da5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 7 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
0H7  A 502 (-3.1A)
None
None
 1.08A 4z4gA-4da5A:
undetectable		 4z4gA-4da5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 5 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
0H7  A 502 (-3.1A)
None
None
 1.08A 4z4hA-4da5A:
undetectable		 4z4hA-4da5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 LEU A 289
LEU A 286
LEU A 282
HIS A 417
LEU A 249
 None
 0.96A 4zn7A-4da5A:
undetectable		 4zn7A-4da5A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 PHE A 347
ILE A 228
CYH A 307
GLN A 308
ILE A 343
 None
None
None
0H7  A 502 (-3.1A)
None
 1.11A 5y2tB-4da5A:
undetectable		 5y2tB-4da5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		3 / 3 ILE A 379
ASN A 410
CYH A 348
 None
 0.89A 6bp4A-4da5A:
undetectable		 6bp4A-4da5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
0H7  A 502 (-3.1A)
None
None
 1.08A 6cbdA-4da5A:
undetectable		 6cbdA-4da5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		3 / 3 LEU A 414
LEU A 292
ARG A 411
 None
 0.57A 6fgcA-4da5A:
undetectable		 6fgcA-4da5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4da5 CHOLINE KINASE ALPHA
(Homo
sapiens) 		3 / 3 LEU A 414
LEU A 292
ARG A 411
 None
 0.60A 6fgdA-4da5A:
undetectable		 6fgdA-4da5A:
20.08