SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4da9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		4 / 8 SER A 172
ALA A 176
PHE A 187
GLU A 188
 None
 1.12A 1dmiA-4da9A:
undetectable
1dmiB-4da9A:
undetectable		 1dmiA-4da9A:
22.78
1dmiB-4da9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		5 / 11 SER A 142
CYH A  87
LEU A  88
THR A  12
ILE A  35
 None
 1.14A 1pkvA-4da9A:
undetectable
1pkvB-4da9A:
undetectable		 1pkvA-4da9A:
15.96
1pkvB-4da9A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		5 / 11 SER A 142
CYH A  87
LEU A  88
THR A  12
ILE A  35
 None
 1.12A 1pkvA-4da9A:
undetectable
1pkvB-4da9A:
undetectable		 1pkvA-4da9A:
15.96
1pkvB-4da9A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 236
GLY A 235
GLY A 232
PHE A 240
SER A 140
 None
 1.20A 1wg8B-4da9A:
9.6		 1wg8B-4da9A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		5 / 12 THR A 121
PHE A 187
VAL A 230
ALA A  92
VAL A 189
 None
 1.24A 2g72A-4da9A:
3.7		 2g72A-4da9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		5 / 12 THR A 121
PHE A 187
VAL A 230
ALA A  92
VAL A 189
 None
 1.21A 2g72B-4da9A:
5.9		 2g72B-4da9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		4 / 6 ASN A 109
LEU A 105
ASP A 100
LYS A 157
 None
 1.49A 3lslG-4da9A:
undetectable		 3lslG-4da9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		4 / 6 ILE A  59
ALA A  34
THR A  36
THR A  74
 None
 1.11A 3mdrA-4da9A:
undetectable		 3mdrA-4da9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		4 / 6 ILE A  59
ALA A  34
THR A  36
THR A  74
 None
 1.08A 3mdrB-4da9A:
undetectable		 3mdrB-4da9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		4 / 4 ASP A  67
ASP A  64
GLY A 120
THR A  12
 None
 1.21A 3tl9B-4da9A:
undetectable		 3tl9B-4da9A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  26
ALA A  23
LEU A  51
ILE A  48
ARG A   6
 None
 1.05A 4dm8B-4da9A:
undetectable		 4dm8B-4da9A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		4 / 5 ILE A  59
ASP A  76
GLU A  81
VAL A   8
 None
 1.17A 4nkxC-4da9A:
undetectable		 4nkxC-4da9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		4 / 5 ILE A  59
ASP A  76
GLU A  81
VAL A   8
 None
 1.17A 4nkxD-4da9A:
undetectable		 4nkxD-4da9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		5 / 10 LEU A 168
SER A 164
ASP A 160
LYS A 157
GLY A  93
 None
 1.48A 6dlzA-4da9A:
3.9
6dlzD-4da9A:
3.9		 6dlzA-4da9A:
13.69
6dlzD-4da9A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A  93
LEU A 168
SER A 164
ASP A 160
LYS A 157
 None
 1.48A 6dlzB-4da9A:
2.3
6dlzC-4da9A:
3.8		 6dlzB-4da9A:
13.69
6dlzC-4da9A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		5 / 10 LEU A 168
SER A 164
ASP A 160
LYS A 157
GLY A  93
 None
 1.48A 6dm1A-4da9A:
4.0
6dm1D-4da9A:
4.0		 6dm1A-4da9A:
13.69
6dm1D-4da9A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A  93
LEU A 168
SER A 164
ASP A 160
LYS A 157
 None
 1.48A 6dm1B-4da9A:
2.3
6dm1C-4da9A:
3.8		 6dm1B-4da9A:
13.69
6dm1C-4da9A:
13.69