SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 5 ARG A 304
ALA A 288
ASP A 306
GLY A 308
 None
 1.19A 1e7bA-4dagA:
undetectable		 1e7bA-4dagA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		3 / 3 GLU A 431
TRP A 309
LYS A 401
 None
 1.39A 1qu2A-4dagA:
undetectable		 1qu2A-4dagA:
17.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4dag FUSION GLYCOPROTEIN
F0
NEUTRALIZING
ANTIBODY DS7 HEAVY
CHAIN
(Homo
sapiens;
Human
metapneumovirus) 		5 / 11 GLY H 104
PRO H 106
TYR H  58
GLU A  26
VAL H  50
 None
None
NAG  A 506 (-4.0A)
None
None
 1.16A 2fl5A-4dagH:
19.2
2fl5B-4dagH:
21.0
2fl5F-4dagH:
21.2		 2fl5A-4dagH:
31.39
2fl5B-4dagH:
73.30
2fl5F-4dagH:
73.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 7 LEU A  39
SER A  37
THR A 281
VAL A 278
 None
 1.13A 2uz2A-4dagA:
undetectable		 2uz2A-4dagA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4dag FUSION GLYCOPROTEIN
F0
NEUTRALIZING
ANTIBODY DS7 HEAVY
CHAIN
(Homo
sapiens;
Human
metapneumovirus) 		4 / 4 ARG H 101
GLY H 104
GLU A  33
SER H  31
 None
 1.31A 2xctS-4dagH:
undetectable
2xctU-4dagH:
2.3		 2xctS-4dagH:
15.37
2xctU-4dagH:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		5 / 9 LEU A  24
TYR A  23
VAL A 430
ILE A 285
VAL A 373
 None
 1.47A 3oxzA-4dagA:
undetectable		 3oxzA-4dagA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		3 / 3 ASN A 313
ALA A 314
LYS A 312
 None
 0.92A 3runA-4dagA:
undetectable		 3runA-4dagA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 5 LEU A 227
ILE A 275
PRO A 274
PHE A 276
 None
 1.23A 3s3vA-4dagA:
undetectable		 3s3vA-4dagA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		5 / 10 PHE A 334
PHE A 276
ASN A 247
ALA A 249
ILE A 217
 None
 1.30A 3t3qA-4dagA:
undetectable		 3t3qA-4dagA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		5 / 10 PHE A 334
PHE A 276
ASN A 247
ALA A 249
ILE A 217
 None
 1.30A 3t3qB-4dagA:
undetectable		 3t3qB-4dagA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		5 / 10 PHE A 334
PHE A 276
ASN A 247
ALA A 249
ILE A 217
 None
 1.31A 3t3qC-4dagA:
undetectable		 3t3qC-4dagA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		5 / 10 PHE A 334
PHE A 276
ASN A 247
ALA A 249
ILE A 217
 None
 1.30A 3t3qD-4dagA:
undetectable		 3t3qD-4dagA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 6 THR A 119
GLY A 121
ARG A 129
ILE A 124
 None
 1.21A 4ac9C-4dagA:
undetectable		 4ac9C-4dagA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4dag FUSION GLYCOPROTEIN
F0
NEUTRALIZING
ANTIBODY DS7 HEAVY
CHAIN
(Human
metapneumovirus;
Homo
sapiens) 		3 / 3 GLY H 104
SER H 103
TRP A 284
 None
 0.79A 4e7cD-4dagH:
undetectable		 4e7cD-4dagH:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4dag FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		5 / 12 GLY A 257
GLY A 255
PRO A 274
LEU A 273
LEU A 221
 None
 1.17A 4x61A-4dagA:
undetectable		 4x61A-4dagA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4dag FUSION GLYCOPROTEIN
F0
NEUTRALIZING
ANTIBODY DS7 HEAVY
CHAIN
(Homo
sapiens;
Human
metapneumovirus) 		4 / 6 ILE A 285
GLY H 104
ILE A 286
TRP A 284
 None
 0.87A 5j4nB-4dagA:
undetectable		 5j4nB-4dagA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4dag NEUTRALIZING
ANTIBODY DS7 HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 MET H 117
SER H 186
LEU H 187
VAL H 159
HIS H 209
 None
 1.01A 5ubbA-4dagH:
undetectable		 5ubbA-4dagH:
18.78