SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 10 ARG A  87
VAL A 177
GLU A 178
MET A 179
GLU A 180
ASP A 203
 None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-4.1A)
 0.54A 1jdvA-4daoA:
32.9
1jdvD-4daoA:
33.0		 1jdvA-4daoA:
31.01
1jdvD-4daoA:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 10 ARG A  87
VAL A 177
GLU A 178
MET A 179
GLU A 180
ASP A 203
 None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-4.1A)
 0.54A 1jdvB-4daoA:
33.0
1jdvC-4daoA:
33.8		 1jdvB-4daoA:
31.01
1jdvC-4daoA:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 10 ARG A  87
VAL A 177
GLU A 178
MET A 179
GLU A 180
ASP A 203
 None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-4.1A)
 0.55A 1jdvA-4daoA:
32.9
1jdvD-4daoA:
33.0		 1jdvA-4daoA:
31.01
1jdvD-4daoA:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 12 ARG A  87
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
 None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
 0.57A 1jdvE-4daoA:
33.1
1jdvF-4daoA:
33.9		 1jdvE-4daoA:
31.01
1jdvF-4daoA:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 12 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.40A 1jdvE-4daoA:
33.1
1jdvF-4daoA:
33.9		 1jdvE-4daoA:
31.01
1jdvF-4daoA:
31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		4 / 7 LEU A  17
TYR A  32
TYR A  52
GLY A  50
 None
 0.94A 1lweA-4daoA:
undetectable		 1lweA-4daoA:
17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 ARG A  87
GLY A  92
GLU A 178
GLU A 180
ILE A  94
 None
ADE  A 301 (-3.5A)
None
None
None
 1.32A 1odiA-4daoA:
24.3		 1odiA-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 ARG A  87
GLY A 176
GLU A 178
GLU A 180
ILE A  94
 None
 1.18A 1odiA-4daoA:
24.3		 1odiA-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 178
MET A 179
GLU A 180
SER A 202
 None
None
ADE  A 301 (-3.5A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
 0.32A 1odiA-4daoA:
24.3		 1odiA-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 11 ARG A  87
GLY A  92
GLU A 178
GLU A 180
SER A 202
ILE A  94
 None
ADE  A 301 (-3.5A)
None
None
ADE  A 301 (-3.5A)
None
 1.23A 1odiB-4daoA:
22.6		 1odiB-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 ARG A  87
GLY A 176
GLU A 178
GLU A 180
ILE A  94
 None
 1.27A 1odiB-4daoA:
22.6		 1odiB-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 178
MET A 179
GLU A 180
SER A 202
 None
None
ADE  A 301 (-3.5A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
 0.34A 1odiB-4daoA:
22.6		 1odiB-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 11 ARG A  87
GLY A  92
GLU A 178
GLU A 180
SER A 202
ILE A  94
 None
ADE  A 301 (-3.5A)
None
None
ADE  A 301 (-3.5A)
None
 1.23A 1odiC-4daoA:
35.0		 1odiC-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 ARG A  87
GLY A 176
GLU A 178
GLU A 180
ILE A  94
 None
 1.21A 1odiC-4daoA:
35.0		 1odiC-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 178
MET A 179
GLU A 180
SER A 202
 None
None
ADE  A 301 (-3.5A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
 0.33A 1odiC-4daoA:
35.0		 1odiC-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 ARG A  87
GLY A  92
GLU A 178
GLU A 180
ILE A  94
 None
ADE  A 301 (-3.5A)
None
None
None
 1.31A 1odiD-4daoA:
34.8		 1odiD-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 ARG A  87
GLY A 176
GLU A 178
GLU A 180
ILE A  94
 None
 1.25A 1odiD-4daoA:
34.8		 1odiD-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 178
MET A 179
GLU A 180
SER A 202
 None
None
ADE  A 301 (-3.5A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
 0.33A 1odiD-4daoA:
34.8		 1odiD-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 11 ARG A  87
GLY A  92
GLU A 178
GLU A 180
SER A 202
ILE A  94
 None
ADE  A 301 (-3.5A)
None
None
ADE  A 301 (-3.5A)
None
 1.23A 1odiE-4daoA:
34.9		 1odiE-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 ARG A  87
GLY A 176
GLU A 178
GLU A 180
ILE A  94
 None
 1.20A 1odiE-4daoA:
34.9		 1odiE-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 178
MET A 179
GLU A 180
SER A 202
 None
None
ADE  A 301 (-3.5A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
 0.36A 1odiE-4daoA:
34.9		 1odiE-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 11 ARG A  87
GLY A  92
GLU A 178
GLU A 180
SER A 202
ILE A  94
 None
ADE  A 301 (-3.5A)
None
None
ADE  A 301 (-3.5A)
None
 1.28A 1odiF-4daoA:
34.9		 1odiF-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 ARG A  87
GLY A 176
GLU A 178
GLU A 180
ILE A  94
 None
 1.21A 1odiF-4daoA:
34.9		 1odiF-4daoA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 178
MET A 179
GLU A 180
SER A 202
 None
None
ADE  A 301 (-3.5A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
 0.36A 1odiF-4daoA:
34.9		 1odiF-4daoA:
36.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 12 ILE A 198
ILE A  57
LEU A  17
VAL A  88
ILE A 224
 None
 0.97A 1oipA-4daoA:
undetectable		 1oipA-4daoA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 9 ARG A  87
GLY A 176
GLU A 178
MET A 179
GLU A 180
 None
None
None
ADE  A 301 ( 4.3A)
None
 1.02A 1pk7A-4daoA:
36.8		 1pk7A-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		9 / 9 MET A  64
ARG A  87
SER A  90
GLY A  92
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
 0.54A 1pk7A-4daoA:
36.8		 1pk7A-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		10 / 10 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
 0.53A 1pk7C-4daoA:
37.7		 1pk7C-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 10 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.49A 1pk9A-4daoA:
36.6		 1pk9A-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		10 / 10 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
 0.57A 1pk9A-4daoA:
36.6		 1pk9A-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 9 ARG A  87
GLY A 176
GLU A 178
MET A 179
GLU A 180
 None
None
None
ADE  A 301 ( 4.3A)
None
 1.01A 1pk9B-4daoA:
37.2		 1pk9B-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		9 / 9 MET A  64
ARG A  87
SER A  90
GLY A  92
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
 0.50A 1pk9B-4daoA:
37.2		 1pk9B-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		9 / 11 ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
ILE A  94
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
None
 1.36A 1pk9C-4daoA:
36.1		 1pk9C-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 11 ARG A  87
VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A 166
 None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.36A 1pk9C-4daoA:
36.1		 1pk9C-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		10 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
 0.61A 1pk9C-4daoA:
36.1		 1pk9C-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 10 ARG A  87
GLY A 176
GLU A 178
MET A 179
GLU A 180
ILE A  94
 None
None
None
ADE  A 301 ( 4.3A)
None
None
 1.07A 1pw7A-4daoA:
36.8		 1pw7A-4daoA:
53.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 10 ARG A  87
SER A  90
GLY A  92
GLU A 178
MET A 179
GLU A 180
ILE A  94
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
None
ADE  A 301 ( 4.3A)
None
None
 1.35A 1pw7A-4daoA:
36.8		 1pw7A-4daoA:
53.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 10 ARG A  87
SER A  90
MET A  64
GLU A 180
SER A 202
 None
ADE  A 301 (-3.4A)
None
None
ADE  A 301 (-3.5A)
 1.50A 1pw7A-4daoA:
36.8		 1pw7A-4daoA:
53.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		9 / 10 MET A  64
ARG A  87
SER A  90
GLY A  92
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
 0.49A 1pw7A-4daoA:
36.8		 1pw7A-4daoA:
53.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 9 ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A  94
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.46A 1pw7B-4daoA:
37.6		 1pw7B-4daoA:
53.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 9 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 0.44A 1pw7B-4daoA:
37.6		 1pw7B-4daoA:
53.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 9 MET A  64
ARG A  87
VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A 166
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.38A 1pw7B-4daoA:
37.6		 1pw7B-4daoA:
53.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 9 MET A  64
SER A  90
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
 0.51A 1pw7C-4daoA:
37.6		 1pw7C-4daoA:
53.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 9 SER A  90
VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A  94
 ADE  A 301 (-3.4A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.48A 1pw7C-4daoA:
37.6		 1pw7C-4daoA:
53.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 9 VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A 166
 ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.35A 1pw7C-4daoA:
37.6		 1pw7C-4daoA:
53.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 10 GLY A  92
PHE A 159
VAL A 177
MET A 179
VAL A 205
 ADE  A 301 (-3.5A)
ADE  A 301 (-4.0A)
ADE  A 301 (-4.4A)
ADE  A 301 ( 4.3A)
ADE  A 301 (-4.3A)
 0.84A 1pwyE-4daoA:
19.8		 1pwyE-4daoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 10 GLY A  92
PHE A 159
VAL A 177
MET A 179
VAL A 205
 ADE  A 301 (-3.5A)
ADE  A 301 (-4.0A)
ADE  A 301 (-4.4A)
ADE  A 301 ( 4.3A)
ADE  A 301 (-4.3A)
 0.76A 1v3qE-4daoA:
19.7		 1v3qE-4daoA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 11 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A  94
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.48A 1vhwA-4daoA:
37.2
1vhwD-4daoA:
37.0		 1vhwA-4daoA:
50.97
1vhwD-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A  94
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.42A 1vhwA-4daoA:
37.2
1vhwD-4daoA:
37.0		 1vhwA-4daoA:
50.97
1vhwD-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 0.47A 1vhwA-4daoA:
37.2
1vhwD-4daoA:
37.0		 1vhwA-4daoA:
50.97
1vhwD-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A 166
 ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.35A 1vhwA-4daoA:
37.2
1vhwD-4daoA:
37.0		 1vhwA-4daoA:
50.97
1vhwD-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 9 ARG A  87
GLY A 176
VAL A 177
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
ADE  A 301 ( 4.3A)
None
 1.44A 1vhwB-4daoA:
37.5
1vhwF-4daoA:
37.0		 1vhwB-4daoA:
50.97
1vhwF-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 9 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
MET A 179
GLU A 180
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
ADE  A 301 ( 4.3A)
None
 0.48A 1vhwB-4daoA:
37.5
1vhwF-4daoA:
37.0		 1vhwB-4daoA:
50.97
1vhwF-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A  94
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.48A 1vhwC-4daoA:
37.1
1vhwE-4daoA:
37.3		 1vhwC-4daoA:
50.97
1vhwE-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 0.46A 1vhwC-4daoA:
37.1
1vhwE-4daoA:
37.3		 1vhwC-4daoA:
50.97
1vhwE-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A 166
 ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.38A 1vhwC-4daoA:
37.1
1vhwE-4daoA:
37.3		 1vhwC-4daoA:
50.97
1vhwE-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 11 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A  94
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.49A 1vhwA-4daoA:
37.2
1vhwD-4daoA:
37.0		 1vhwA-4daoA:
50.97
1vhwD-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A  94
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.45A 1vhwA-4daoA:
37.2
1vhwD-4daoA:
37.0		 1vhwA-4daoA:
50.97
1vhwD-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 0.45A 1vhwA-4daoA:
37.2
1vhwD-4daoA:
37.0		 1vhwA-4daoA:
50.97
1vhwD-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A 166
 ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.36A 1vhwA-4daoA:
37.2
1vhwD-4daoA:
37.0		 1vhwA-4daoA:
50.97
1vhwD-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 11 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A  94
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.47A 1vhwC-4daoA:
37.1
1vhwE-4daoA:
37.3		 1vhwC-4daoA:
50.97
1vhwE-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A  94
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.41A 1vhwC-4daoA:
37.1
1vhwE-4daoA:
37.3		 1vhwC-4daoA:
50.97
1vhwE-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 0.45A 1vhwC-4daoA:
37.1
1vhwE-4daoA:
37.3		 1vhwC-4daoA:
50.97
1vhwE-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 VAL A 177
GLU A 178
MET A 179
GLU A 180
ILE A 166
 ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
None
 1.35A 1vhwC-4daoA:
37.1
1vhwE-4daoA:
37.3		 1vhwC-4daoA:
50.97
1vhwE-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 10 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.44A 1vhwB-4daoA:
37.5
1vhwF-4daoA:
37.0		 1vhwB-4daoA:
50.97
1vhwF-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 10 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 0.48A 1vhwB-4daoA:
37.5
1vhwF-4daoA:
37.0		 1vhwB-4daoA:
50.97
1vhwF-4daoA:
50.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 10 MET A  64
ARG A  87
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
 None
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
 0.47A 1z35A-4daoA:
36.2		 1z35A-4daoA:
46.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 9 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.44A 1z37A-4daoA:
36.2		 1z37A-4daoA:
46.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 9 MET A  64
ARG A  87
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
 None
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
 0.31A 1z37A-4daoA:
36.2		 1z37A-4daoA:
46.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 11 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.49A 2ac7A-4daoA:
37.8
2ac7B-4daoA:
37.9		 2ac7A-4daoA:
71.37
2ac7B-4daoA:
71.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 MET A  64
ARG A  87
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
ASP A 203
 None
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-4.1A)
 0.63A 2ac7A-4daoA:
37.8
2ac7B-4daoA:
37.9		 2ac7A-4daoA:
71.37
2ac7B-4daoA:
71.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 11 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.49A 2ac7A-4daoA:
37.8
2ac7B-4daoA:
37.9		 2ac7A-4daoA:
71.37
2ac7B-4daoA:
71.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 MET A  64
ARG A  87
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
ASP A 203
 None
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-4.1A)
 0.63A 2ac7A-4daoA:
37.8
2ac7B-4daoA:
37.9		 2ac7A-4daoA:
71.37
2ac7B-4daoA:
71.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 10 LEU A  76
GLY A   6
ALA A   7
VAL A  16
ILE A  12
 None
 0.90A 3em3A-4daoA:
undetectable		 3em3A-4daoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 11 ALA A 106
ILE A 104
SER A 152
LEU A 175
VAL A 177
 None
None
None
None
ADE  A 301 (-4.4A)
 0.98A 3gyqB-4daoA:
2.6		 3gyqB-4daoA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		3 / 3 ARG A  24
VAL A 100
THR A 211
 None
 0.83A 3k4vA-4daoA:
undetectable		 3k4vA-4daoA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 9 LEU A  76
GLY A   6
ALA A   7
VAL A  16
ILE A  12
 None
 0.93A 3oxvA-4daoA:
undetectable		 3oxvA-4daoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 12 GLY A 176
VAL A 201
LEU A 169
LEU A 206
SER A 152
 None
 1.04A 3p2kD-4daoA:
undetectable		 3p2kD-4daoA:
23.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_A_ADNA251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 9 MET A  64
ARG A  87
SER A  90
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 0.43A 3u40A-4daoA:
22.7
3u40F-4daoA:
35.1		 3u40A-4daoA:
43.31
3u40F-4daoA:
43.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 10 MET A  64
ARG A  87
SER A  90
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 0.35A 3u40B-4daoA:
35.9
3u40C-4daoA:
35.2		 3u40B-4daoA:
43.31
3u40C-4daoA:
43.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 12 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.40A 3u40B-4daoA:
35.9
3u40C-4daoA:
35.2		 3u40B-4daoA:
43.31
3u40C-4daoA:
43.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		9 / 12 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
ASP A 203
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-4.1A)
 0.57A 3u40B-4daoA:
35.9
3u40C-4daoA:
35.2		 3u40B-4daoA:
43.31
3u40C-4daoA:
43.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 11 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.38A 3u40D-4daoA:
22.7
3u40E-4daoA:
34.9		 3u40D-4daoA:
43.31
3u40E-4daoA:
43.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		9 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
ASP A 203
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-4.1A)
 0.61A 3u40D-4daoA:
22.7
3u40E-4daoA:
34.9		 3u40D-4daoA:
43.31
3u40E-4daoA:
43.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 12 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.41A 3u40D-4daoA:
22.7
3u40E-4daoA:
34.9		 3u40D-4daoA:
43.31
3u40E-4daoA:
43.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		9 / 12 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
ASP A 203
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-4.1A)
 0.61A 3u40D-4daoA:
22.7
3u40E-4daoA:
34.9		 3u40D-4daoA:
43.31
3u40E-4daoA:
43.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 10 MET A  64
ARG A  87
SER A  90
VAL A 177
GLU A 178
MET A 179
GLU A 180
ASP A 203
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-4.1A)
 0.68A 3u40A-4daoA:
22.7
3u40F-4daoA:
35.1		 3u40A-4daoA:
43.31
3u40F-4daoA:
43.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 11 ARG A  87
GLY A 176
VAL A 177
GLU A 178
GLU A 180
ILE A  94
 None
None
ADE  A 301 (-4.4A)
None
None
None
 1.49A 3uawA-4daoA:
38.3		 3uawA-4daoA:
71.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 MET A  64
ARG A  87
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
 None
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
 0.40A 3uawA-4daoA:
38.3		 3uawA-4daoA:
71.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 11 MET A  64
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
 None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
 0.67A 3uawA-4daoA:
38.3		 3uawA-4daoA:
71.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 10 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.48A 3uayA-4daoA:
39.4		 3uayA-4daoA:
70.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 10 MET A  64
ARG A  87
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 0.33A 3uayA-4daoA:
39.4		 3uayA-4daoA:
70.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 10 ILE A  69
LEU A 184
THR A  62
GLY A  20
GLY A  89
 None
 1.22A 4bwlC-4daoA:
undetectable		 4bwlC-4daoA:
24.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 11 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.36A 4d9hA-4daoA:
43.2		 4d9hA-4daoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		11 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
VAL A 205
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
ADE  A 301 (-4.3A)
 0.42A 4d9hA-4daoA:
43.2		 4d9hA-4daoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 9 MET A  64
SER A  90
GLY A  92
VAL A 177
MET A 179
GLU A 180
ASP A 203
VAL A 205
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-4.1A)
ADE  A 301 (-4.3A)
 0.51A 4da6A-4daoA:
42.0		 4da6A-4daoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 9 MET A  64
SER A  90
GLY A  92
VAL A 177
MET A 179
GLU A 180
SER A 202
ASP A 203
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
 0.64A 4da6A-4daoA:
42.0		 4da6A-4daoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		7 / 10 ARG A  87
GLY A 176
ALA A 156
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.30A 4da7A-4daoA:
42.4		 4da7A-4daoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		10 / 10 MET A  64
ARG A  87
GLY A  92
ALA A 156
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
VAL A 205
 None
None
ADE  A 301 (-3.5A)
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.3A)
 0.39A 4da7A-4daoA:
42.4		 4da7A-4daoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 11 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.35A 4danA-4daoA:
42.6		 4danA-4daoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		11 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
VAL A 205
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
ADE  A 301 (-4.3A)
 0.50A 4danA-4daoA:
42.6		 4danA-4daoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		6 / 12 ARG A  87
GLY A 176
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 1.33A 4danA-4daoA:
42.6
4danB-4daoA:
42.3		 4danA-4daoA:
100.00
4danB-4daoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		10 / 12 ARG A  87
SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
VAL A 205
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
ADE  A 301 (-4.3A)
 0.56A 4danA-4daoA:
42.6
4danB-4daoA:
42.3		 4danA-4daoA:
100.00
4danB-4daoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 9 MET A  64
ARG A  87
SER A  90
GLY A  92
ALA A 156
VAL A 177
MET A 179
GLU A 180
 None
None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
None
ADE  A 301 (-4.4A)
ADE  A 301 ( 4.3A)
None
 0.49A 5i3cA-4daoA:
37.1		 5i3cA-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		8 / 10 MET A  64
SER A  90
GLY A  92
ALA A 156
VAL A 177
GLU A 178
MET A 179
GLU A 180
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
 0.46A 5i3cB-4daoA:
37.2		 5i3cB-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		9 / 11 MET A  64
GLY A  92
ALA A 156
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
ASP A 203
 None
ADE  A 301 (-3.5A)
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
ADE  A 301 (-4.1A)
 0.68A 5i3cC-4daoA:
36.9		 5i3cC-4daoA:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		9 / 11 MET A  64
SER A  90
GLY A  92
ALA A 156
VAL A 177
GLU A 178
MET A 179
GLU A 180
SER A 202
 None
ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
None
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
None
ADE  A 301 (-3.5A)
 0.45A 5i3cC-4daoA:
36.9		 5i3cC-4daoA:
53.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		3 / 3 THR A 181
SER A 109
ASP A 112
 None
 0.77A 5kvaA-4daoA:
undetectable		 5kvaA-4daoA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		3 / 3 THR A 181
SER A 109
ASP A 112
 None
 0.79A 5kvaB-4daoA:
undetectable		 5kvaB-4daoA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 12 ILE A 198
ILE A  57
LEU A  17
VAL A  88
ILE A 224
 None
 0.95A 5mueA-4daoA:
undetectable		 5mueA-4daoA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		5 / 9 SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
 ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
 0.40A 5zncA-4daoA:
32.0		 5zncA-4daoA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE
(Bacillus
subtilis) 		4 / 8 ILE A  57
ALA A 227
VAL A 226
MET A 223
 None
 0.99A 6hu9a-4daoA:
undetectable
6hu9e-4daoA:
undetectable		 6hu9a-4daoA:
19.18
6hu9e-4daoA:
16.02