SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		3 / 3 THR A  66
PRO A  64
THR A  55
 None
 0.81A 209dC-4dapA:
undetectable		 209dC-4dapA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		5 / 12 LEU A  33
LEU A  12
MET A  41
CYH A  79
THR A  82
 None
 1.47A 2aa5A-4dapA:
undetectable		 2aa5A-4dapA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		5 / 12 LEU A  33
LEU A  12
MET A  41
CYH A  79
THR A  82
 None
 1.44A 2aa5B-4dapA:
undetectable		 2aa5B-4dapA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		5 / 12 LEU A  33
LEU A  12
MET A  41
CYH A  79
THR A  82
 None
 1.45A 2aa6B-4dapA:
undetectable		 2aa6B-4dapA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		6 / 12 ALA A  40
ASP A 151
GLY A  39
ASN A  37
ALA A 152
THR A 154
 None
 1.11A 2c49A-4dapA:
undetectable		 2c49A-4dapA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		4 / 5 SER A  74
THR A  46
SER A  72
ASP A  49
 None
 1.29A 2hdnB-4dapA:
2.1
2hdnC-4dapA:
undetectable
2hdnD-4dapA:
2.2		 2hdnB-4dapA:
22.69
2hdnC-4dapA:
13.66
2hdnD-4dapA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		4 / 6 THR A  46
SER A  72
ASP A  49
SER A  74
 None
 1.30A 2hdnI-4dapA:
undetectable
2hdnJ-4dapA:
undetectable
2hdnL-4dapA:
2.5		 2hdnI-4dapA:
13.66
2hdnJ-4dapA:
22.69
2hdnL-4dapA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		4 / 6 SER A  74
THR A  46
SER A  72
ASP A  49
 None
 1.31A 2hdnJ-4dapA:
undetectable
2hdnK-4dapA:
undetectable
2hdnL-4dapA:
2.5		 2hdnJ-4dapA:
22.69
2hdnK-4dapA:
13.66
2hdnL-4dapA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		4 / 7 PHE A 177
ALA A  92
LEU A  88
ALA A 179
 None
 1.01A 2vcvA-4dapA:
undetectable		 2vcvA-4dapA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		4 / 7 PHE A 177
ALA A  92
LEU A  88
ALA A 179
 None
 1.00A 2vcvL-4dapA:
undetectable		 2vcvL-4dapA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		5 / 11 PRO A 231
ILE A 185
VAL A 180
PHE A 178
VAL A 139
 None
 1.17A 3rf4A-4dapA:
undetectable
3rf4C-4dapA:
undetectable		 3rf4A-4dapA:
19.73
3rf4C-4dapA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		5 / 9 ALA A 217
ALA A 225
ALA A  92
SER A  97
ALA A 179
 None
 1.29A 4twdA-4dapA:
undetectable
4twdB-4dapA:
undetectable
4twdC-4dapA:
undetectable
4twdD-4dapA:
undetectable
4twdE-4dapA:
undetectable		 4twdA-4dapA:
23.72
4twdB-4dapA:
23.72
4twdC-4dapA:
23.72
4twdD-4dapA:
23.72
4twdE-4dapA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		4 / 6 ASN A  95
GLU A 100
TYR A 215
LEU A 226
 None
 0.80A 4twdB-4dapA:
undetectable
4twdC-4dapA:
undetectable		 4twdB-4dapA:
23.72
4twdC-4dapA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		4 / 6 ASN A  95
GLU A 100
TYR A 215
LEU A 226
 None
 0.75A 4twdD-4dapA:
undetectable
4twdE-4dapA:
undetectable		 4twdD-4dapA:
23.72
4twdE-4dapA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A
(Escherichia
coli) 		4 / 6 ASN A  95
GLU A 100
TYR A 215
LEU A 226
 None
 0.80A 4twdI-4dapA:
undetectable
4twdJ-4dapA:
undetectable		 4twdI-4dapA:
23.72
4twdJ-4dapA:
23.72