SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4dav SUGAR FERMENTATION
STIMULATION PROTEIN
HOMOLOG
(Pyrococcus
furiosus) 		4 / 7 LEU A 162
GLU A 126
LEU A 119
GLY A 112
 None
 0.78A 1n13D-4davA:
undetectable
1n13E-4davA:
undetectable		 1n13D-4davA:
20.70
1n13E-4davA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 4dav SUGAR FERMENTATION
STIMULATION PROTEIN
HOMOLOG
(Pyrococcus
furiosus) 		5 / 11 VAL A 180
GLY A 175
ILE A 174
LYS A 132
SER A 133
 None
 1.19A 3bjwB-4davA:
undetectable		 3bjwB-4davA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4dav SUGAR FERMENTATION
STIMULATION PROTEIN
HOMOLOG
(Pyrococcus
furiosus) 		5 / 12 ILE A  78
PHE A  69
ALA A 134
VAL A 135
PRO A 178
 None
 1.03A 3jb3A-4davA:
undetectable		 3jb3A-4davA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4dav SUGAR FERMENTATION
STIMULATION PROTEIN
HOMOLOG
(Pyrococcus
furiosus) 		4 / 7 GLY A 152
ILE A 171
LEU A 197
PHE A 173
 None
 0.74A 4ejjD-4davA:
undetectable		 4ejjD-4davA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 4dav SUGAR FERMENTATION
STIMULATION PROTEIN
HOMOLOG
(Pyrococcus
furiosus) 		5 / 12 LEU A  42
ALA A 176
ILE A  36
GLY A  68
GLY A  52
 None
 1.27A 4hfpB-4davA:
undetectable		 4hfpB-4davA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4dav SUGAR FERMENTATION
STIMULATION PROTEIN
HOMOLOG
(Pyrococcus
furiosus) 		5 / 9 TYR A 144
ILE A 171
LEU A 159
ARG A 151
GLY A 152
 None
 1.34A 5ifuB-4davA:
undetectable		 5ifuB-4davA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4dav SUGAR FERMENTATION
STIMULATION PROTEIN
HOMOLOG
(Pyrococcus
furiosus) 		4 / 6 ASP A 117
HIS A 155
ILE A 171
TYR A 144
 None
 1.17A 5ih0A-4davA:
undetectable		 5ih0A-4davA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4dav SUGAR FERMENTATION
STIMULATION PROTEIN
HOMOLOG
(Pyrococcus
furiosus) 		5 / 10 VAL A 172
LEU A 210
LEU A 212
LEU A  95
LEU A  96
 None
 0.90A 6f6nA-4davA:
undetectable
6f6nB-4davA:
undetectable		 6f6nA-4davA:
16.37
6f6nB-4davA:
18.23