SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4db3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 VAL A  29
GLU A  27
LEU A  88
LEU A  92
GLY A  15
None
1.04A 1jffB-4db3A:
undetectable
1jffB-4db3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
4 / 6 LEU A 138
GLY A 153
LEU A 128
ILE A 240
None
0.83A 1yajF-4db3A:
undetectable
1yajF-4db3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
4 / 6 TYR A 262
GLY A 133
PHE A 134
SER A 190
None
1.25A 2a3cB-4db3A:
undetectable
2a3cB-4db3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 11 LEU A 130
LEU A 255
ILE A 282
PRO A 266
LEU A 185
None
1.30A 2ft9A-4db3A:
undetectable
2ft9A-4db3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 VAL A  29
GLU A  27
LEU A  88
LEU A  92
GLY A  15
None
1.04A 2hxfB-4db3A:
undetectable
2hxfB-4db3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 VAL A  29
GLU A  27
LEU A  88
LEU A  92
GLY A  15
None
1.04A 2hxhB-4db3A:
undetectable
2hxhB-4db3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
3 / 3 CYH A 179
CYH A 184
HIS A 157
ZN  A 401 (-2.3A)
ZN  A 401 (-2.2A)
ZN  A 401 (-3.2A)
0.82A 2iwkA-4db3A:
undetectable
2iwkA-4db3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
3 / 3 CYH A 179
CYH A 184
HIS A 157
ZN  A 401 (-2.3A)
ZN  A 401 (-2.2A)
ZN  A 401 (-3.2A)
0.81A 2iwkB-4db3A:
undetectable
2iwkB-4db3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 VAL A  29
GLU A  27
LEU A  88
LEU A  92
GLY A  15
None
1.04A 2p4nB-4db3A:
undetectable
2p4nB-4db3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 291
GLY A   4
GLY A 295
ASP A   6
ILE A  12
None
0.87A 2pxcA-4db3A:
undetectable
2pxcA-4db3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
4 / 7 LEU A 232
GLU A 264
LEU A 260
TYR A 201
None
1.01A 2w8yA-4db3A:
undetectable
2w8yA-4db3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 291
GLY A  15
THR A  42
ASP A   6
ILE A  12
None
0.96A 2wa2B-4db3A:
undetectable
2wa2B-4db3A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 VAL A  29
GLU A  27
LEU A  88
LEU A  92
GLY A  15
None
1.04A 2wbeB-4db3A:
undetectable
2wbeB-4db3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A  63
GLY A 292
ASN A 104
PRO A  65
VAL A  80
None
1.00A 2zulA-4db3A:
undetectable
2zulA-4db3A:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 252
GLY A 127
LEU A 128
ALA A 250
VAL A 249
None
1.01A 3av6A-4db3A:
undetectable
3av6A-4db3A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 VAL A  29
GLU A  27
LEU A  88
LEU A  92
GLY A  15
None
1.04A 3dcoB-4db3A:
undetectable
3dcoB-4db3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A  63
GLY A 292
ASN A 104
PRO A  65
VAL A  80
None
1.01A 3dmfA-4db3A:
undetectable
3dmfA-4db3A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A  63
GLY A 292
ASN A 104
PRO A  65
VAL A  80
None
1.02A 3dmhA-4db3A:
undetectable
3dmhA-4db3A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
3 / 3 CYH A 179
CYH A 184
HIS A 157
ZN  A 401 (-2.3A)
ZN  A 401 (-2.2A)
ZN  A 401 (-3.2A)
0.76A 3dtuB-4db3A:
undetectable
3dtuB-4db3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
3 / 3 CYH A 179
CYH A 184
HIS A 157
ZN  A 401 (-2.3A)
ZN  A 401 (-2.2A)
ZN  A 401 (-3.2A)
0.74A 3dtuD-4db3A:
undetectable
3dtuD-4db3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 VAL A  29
GLU A  27
LEU A  88
LEU A  92
GLY A  15
None
1.03A 3edlB-4db3A:
undetectable
3edlB-4db3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 LEU A 251
GLY A 252
LEU A 130
TYR A 262
ILE A 261
None
1.09A 3gwwA-4db3A:
undetectable
3gwwA-4db3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 VAL A  29
GLU A  27
LEU A  88
LEU A  92
GLY A  15
None
1.03A 3iz0B-4db3A:
undetectable
3iz0B-4db3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 ILE A 240
GLY A 238
ALA A 277
ALA A 234
PRO A 280
None
1.10A 3jb3A-4db3A:
undetectable
3jb3A-4db3A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 11 GLY A 142
ILE A 139
PHE A 298
ALA A 114
GLN A 120
None
1.22A 3nmuB-4db3A:
3.4
3nmuJ-4db3A:
undetectable
3nmuB-4db3A:
24.56
3nmuJ-4db3A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 191
GLY A 133
ALA A 208
LEU A 189
LEU A 255
None
1.08A 3p2kB-4db3A:
undetectable
3p2kB-4db3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 TYR A 262
ILE A 240
ILE A 261
PHE A 134
LEU A 130
None
1.10A 3vw1B-4db3A:
undetectable
3vw1B-4db3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
3 / 3 ARG A  28
ARG A  23
ASP A 289
None
0.96A 3wipG-4db3A:
undetectable
3wipH-4db3A:
undetectable
3wipG-4db3A:
18.98
3wipH-4db3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
4 / 7 VAL A 226
ILE A 211
ASN A 215
GLU A 263
None
1.05A 4a97H-4db3A:
undetectable
4a97H-4db3A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 291
GLY A   4
GLY A 295
ASP A   6
ILE A  12
None
0.94A 4ctjC-4db3A:
undetectable
4ctjC-4db3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
4 / 6 ILE A 240
ILE A 282
PHE A 134
LEU A 233
None
0.95A 4m51A-4db3A:
undetectable
4m51A-4db3A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 291
GLY A   4
GLY A 295
ASP A   6
ILE A  12
None
0.94A 5ehiA-4db3A:
undetectable
5ehiA-4db3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 291
GLY A   4
GLY A 295
ASP A   6
ILE A  12
None
0.95A 5ekxA-4db3A:
undetectable
5ekxA-4db3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
4 / 4 LEU A 128
LEU A 138
GLY A 153
GLU A 154
None
1.15A 5hhjA-4db3A:
undetectable
5hhjA-4db3A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
4 / 8 GLY A 136
PHE A 194
CYH A 236
ASP A 186
None
0.91A 5hieD-4db3A:
undetectable
5hieD-4db3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 291
GLY A   4
GLY A 295
ASP A   6
ILE A  12
None
0.88A 5ikmA-4db3A:
undetectable
5ikmA-4db3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 291
GLY A   4
GLY A 295
ASP A   6
ILE A  12
None
0.91A 5kqsA-4db3A:
undetectable
5kqsA-4db3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 291
GLY A   4
GLY A 295
ASP A   6
ILE A  12
None
0.91A 5njvC-4db3A:
undetectable
5njvC-4db3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 291
GLY A   4
GLY A 295
ASP A   6
ILE A  12
None
0.90A 5wz2A-4db3A:
undetectable
5wz2A-4db3A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
5 / 12 GLY A 291
GLY A   4
GLY A 295
ASP A   6
ILE A  12
None
0.91A 5wz2C-4db3A:
undetectable
5wz2C-4db3A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus)
4 / 6 VAL A  80
LEU A  64
LEU A  62
TYR A  36
None
1.05A 6f6sA-4db3A:
undetectable
6f6sB-4db3A:
undetectable
6f6sA-4db3A:
12.65
6f6sB-4db3A:
13.12