SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4db4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.14A 1c9hA-4db4A:
undetectable		 1c9hA-4db4A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 592
SER A 535
ILE A 534
LEU A 580
 None
 0.90A 1eupA-4db4A:
undetectable		 1eupA-4db4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.10A 1fkfA-4db4A:
undetectable		 1fkfA-4db4A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.11A 1fkjA-4db4A:
undetectable		 1fkjA-4db4A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.06A 1fklA-4db4A:
undetectable		 1fklA-4db4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 431
LEU A 562
THR A 558
PRO A 381
GLY A 452
 None
 1.17A 1jffB-4db4A:
undetectable		 1jffB-4db4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 388
GLY A 560
ILE A 529
VAL A 530
 None
 0.77A 1p2yA-4db4A:
undetectable		 1p2yA-4db4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.18A 1tcoC-4db4A:
undetectable		 1tcoC-4db4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.12A 2fkeA-4db4A:
undetectable		 2fkeA-4db4A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 431
LEU A 562
THR A 558
PRO A 381
GLY A 452
 None
 1.17A 2hxfB-4db4A:
undetectable		 2hxfB-4db4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 431
LEU A 562
THR A 558
PRO A 381
GLY A 452
 None
 1.17A 2hxhB-4db4A:
undetectable		 2hxhB-4db4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 431
LEU A 562
THR A 558
PRO A 381
GLY A 452
 None
 1.17A 2p4nB-4db4A:
undetectable		 2p4nB-4db4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 431
LEU A 562
THR A 558
PRO A 381
GLY A 452
 None
 1.17A 2wbeB-4db4A:
undetectable		 2wbeB-4db4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 431
LEU A 562
THR A 558
PRO A 381
GLY A 452
 None
 1.17A 3dcoB-4db4A:
undetectable		 3dcoB-4db4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 497
GLN A 502
ILE A 342
LEU A 485
 None
 0.98A 3dzyD-4db4A:
undetectable		 3dzyD-4db4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 497
GLN A 502
ILE A 464
LEU A 485
 None
 1.09A 3dzyD-4db4A:
undetectable		 3dzyD-4db4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 431
LEU A 562
THR A 558
PRO A 381
GLY A 452
 None
 1.16A 3edlB-4db4A:
undetectable		 3edlB-4db4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 431
LEU A 562
THR A 558
PRO A 381
GLY A 452
 None
 1.17A 3iz0B-4db4A:
undetectable		 3iz0B-4db4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 552
PRO A 381
ALA A 556
LEU A 562
ILE A 526
 None
 1.00A 3ku1H-4db4A:
2.9		 3ku1H-4db4A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 SER A 557
LEU A 582
ILE A 570
PHE A 592
 None
 0.97A 3ln1C-4db4A:
undetectable		 3ln1C-4db4A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 385
ILE A 529
ALA A 353
ILE A 392
VAL A 519
 None
 1.09A 3me6A-4db4A:
undetectable		 3me6A-4db4A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.16A 3nbqA-4db4A:
undetectable		 3nbqA-4db4A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 0.85A 3nbqB-4db4A:
undetectable		 3nbqB-4db4A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 0.89A 3nbqC-4db4A:
undetectable		 3nbqC-4db4A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.22A 3o5rA-4db4A:
undetectable		 3o5rA-4db4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.08A 3vawA-4db4A:
undetectable		 3vawA-4db4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 484
ILE A 480
PHE A 352
VAL A 515
 None
 1.21A 4a97I-4db4A:
undetectable		 4a97I-4db4A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.09A 4driA-4db4A:
undetectable		 4driA-4db4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.14A 4drjA-4db4A:
undetectable		 4drjA-4db4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 385
PHE A 352
ILE A 451
GLY A 452
 None
 0.92A 4ejjC-4db4A:
undetectable		 4ejjC-4db4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.19A 4laxA-4db4A:
undetectable		 4laxA-4db4A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 478
GLU A 484
SER A 349
VAL A 488
 None
 0.98A 4wnvD-4db4A:
undetectable		 4wnvD-4db4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.14A 5hkgA-4db4A:
undetectable		 5hkgA-4db4A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 546
TYR A 537
LEU A 389
ILE A 451
GLY A 452
 None
 1.23A 5ifuA-4db4A:
undetectable		 5ifuA-4db4A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 431
LEU A 562
THR A 558
PRO A 381
GLY A 452
 None
 1.19A 5ogcB-4db4A:
undetectable		 5ogcB-4db4A:
19.22