SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4db5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 4db5 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18
(Oryctolagus
cuniculus) 		5 / 9 GLY A  41
ASP A  91
ASP A  94
ILE A  96
ILE A  87
 None
B3P  A 201 (-4.9A)
None
None
None
 0.92A 3s53A-4db5A:
undetectable		 3s53A-4db5A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4db5 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18
(Oryctolagus
cuniculus) 		4 / 5 PHE A  90
GLY A 114
ILE A  37
VAL A  27
 None
 0.84A 3wrkA-4db5A:
undetectable		 3wrkA-4db5A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4db5 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18
(Oryctolagus
cuniculus) 		4 / 5 TYR A  43
GLN A  39
GLY A  41
SER A 124
 None
 1.18A 4fu8A-4db5A:
undetectable		 4fu8A-4db5A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4db5 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18
(Oryctolagus
cuniculus) 		5 / 11 GLY A  41
ASP A  91
ASP A  94
ILE A  96
ILE A  87
 None
B3P  A 201 (-4.9A)
None
None
None
 0.83A 4q1xA-4db5A:
undetectable		 4q1xA-4db5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 4db5 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18
(Oryctolagus
cuniculus) 		5 / 10 GLY A  41
ASP A  91
ASP A  94
ILE A  96
ILE A  87
 None
B3P  A 201 (-4.9A)
None
None
None
 0.83A 4q1yA-4db5A:
undetectable		 4q1yA-4db5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 4db5 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18
(Oryctolagus
cuniculus) 		5 / 12 GLY A  41
ASP A  91
ASP A  94
ILE A  96
ILE A  87
 None
B3P  A 201 (-4.9A)
None
None
None
 0.80A 5e5kA-4db5A:
undetectable		 5e5kA-4db5A:
23.20