SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dbe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  47
MET A  10
GLY A  32
PHE A  60
LEU A  14
 None
 1.37A 1brpA-4dbeA:
undetectable		 1brpA-4dbeA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 SER A 189
GLY A 167
TYR A 173
GLY A 187
SER A 163
 None
None
None
BMP  A 301 (-3.3A)
None
 1.07A 1fduC-4dbeA:
undetectable		 1fduC-4dbeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 7 TYR A 183
VAL A 162
TYR A 109
ILE A  57
 None
 1.11A 2x45B-4dbeA:
undetectable		 2x45B-4dbeA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 7 TYR A 183
VAL A 162
TYR A 109
ILE A  57
 None
 1.13A 2x45C-4dbeA:
undetectable		 2x45C-4dbeA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 7 TYR A 183
VAL A 162
TYR A 109
ILE A  57
 None
 1.13A 3bu1A-4dbeA:
undetectable		 3bu1A-4dbeA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_C_ACTC207_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 4 LYS A 137
PRO A 136
LEU A 108
ASN A 107
 None
 1.28A 3tpxC-4dbeA:
0.0		 3tpxC-4dbeA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A 146
ALA A 181
ASP A 182
VAL A 141
ILE A 149
 None
 1.24A 3wsjA-4dbeA:
undetectable		 3wsjA-4dbeA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		3 / 3 LEU A 200
MET A  22
ASP A 182
 None
 0.51A 4j7xB-4dbeA:
undetectable		 4j7xB-4dbeA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 138
ILE A 134
SER A 135
ILE A  57
SER A  81
 None
 1.05A 4qtuD-4dbeA:
undetectable		 4qtuD-4dbeA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 8 THR A 150
GLY A 143
GLY A 142
VAL A 141
 None
 0.80A 4qvvK-4dbeA:
undetectable
4qvvL-4dbeA:
undetectable		 4qvvK-4dbeA:
23.11
4qvvL-4dbeA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 8 THR A 150
GLY A 143
GLY A 142
VAL A 141
 None
 0.80A 4qvvY-4dbeA:
undetectable
4qvvZ-4dbeA:
undetectable		 4qvvY-4dbeA:
23.11
4qvvZ-4dbeA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		3 / 3 GLY A 142
GLY A 143
GLN A 169
 None
None
BMP  A 301 (-3.3A)
 0.45A 5imsA-4dbeA:
undetectable		 5imsA-4dbeA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 7 LEU A   8
GLU A  55
ASN A 204
ILE A 207
 None
 1.19A 5jh7C-4dbeA:
undetectable		 5jh7C-4dbeA:
20.13