SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  99
ALA A  56
ILE A 176
ILE A 144
VAL A  63
 None
 0.84A 1muiB-4dbhA:
undetectable		 1muiB-4dbhA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		5 / 12 THR A 143
GLY A 117
GLY A 241
GLU A  76
ILE A 145
 None
 1.00A 2fk8A-4dbhA:
undetectable		 2fk8A-4dbhA:
28.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		5 / 5 GLU A 254
PRO A 256
ILE A 255
GLY A 259
LYS A 191
 None
 1.48A 2qeuA-4dbhA:
undetectable
2qeuC-4dbhA:
undetectable		 2qeuA-4dbhA:
22.87
2qeuC-4dbhA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		4 / 8 ASP A 147
LYS A 164
GLY A 237
GLU A 118
 MG  A 401 ( 2.9A)
OXL  A 402 ( 2.5A)
OXL  A 402 (-3.6A)
MG  A 401 ( 2.6A)
 0.88A 2ys6A-4dbhA:
undetectable		 2ys6A-4dbhA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  99
ALA A  56
ILE A 176
ILE A 144
VAL A  63
 None
 0.95A 3d1xB-4dbhA:
undetectable		 3d1xB-4dbhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		5 / 12 ASN A 146
ILE A 251
GLY A 241
ALA A 240
GLY A 117
 None
 0.87A 3hs6B-4dbhA:
undetectable		 3hs6B-4dbhA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		4 / 4 ILE A 104
PHE A 169
ILE A 106
THR A  98
 None
 1.14A 3ia4A-4dbhA:
undetectable		 3ia4A-4dbhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		4 / 5 ILE A 106
THR A 111
SER A 150
PHE A 169
 None
 1.21A 3snfA-4dbhA:
undetectable		 3snfA-4dbhA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		5 / 12 ASN A 146
ILE A 251
GLY A 241
ALA A 240
GLY A 117
 None
 0.84A 4e1gA-4dbhA:
undetectable		 4e1gA-4dbhA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		4 / 8 GLY A  99
GLY A 170
ILE A 145
GLU A 116
 None
None
None
MG  A 401 ( 2.9A)
 0.85A 4mwzB-4dbhA:
undetectable		 4mwzB-4dbhA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 141
ASP A 179
ILE A 123
GLY A 231
PHE A  37
 None
 1.14A 4obwC-4dbhA:
undetectable		 4obwC-4dbhA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		4 / 7 LEU A  55
LEU A  59
ILE A 145
VAL A 233
 None
 0.85A 4ojbA-4dbhA:
undetectable		 4ojbA-4dbhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		5 / 11 GLY A  99
ALA A  56
ILE A 176
ILE A 144
VAL A  63
 None
 0.93A 4qgiA-4dbhA:
undetectable		 4qgiA-4dbhA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE
(Corynebacterium
glutamicum) 		5 / 9 ILE A 253
ILE A 255
GLN A 204
GLU A 114
ILE A 144
 None
 1.47A 6hloA-4dbhA:
undetectable		 6hloA-4dbhA:
19.89