SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dcc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A 200
ALA A 196
VAL A  16
 None
 0.88A 1av2C-4dccA:
undetectable
1av2D-4dccA:
undetectable		 1av2C-4dccA:
5.63
1av2D-4dccA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A 200
ALA A 196
VAL A  16
 None
 0.97A 1w5uA-4dccA:
undetectable
1w5uB-4dccA:
undetectable		 1w5uA-4dccA:
5.63
1w5uB-4dccA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLY A  14
SER A 112
VAL A 122
LEU A  20
 CL  A 301 ( 3.6A)
CL  A 301 (-2.8A)
None
None
 0.98A 1yajB-4dccA:
undetectable		 1yajB-4dccA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 196
VAL A  16
TRP A 200
 None
 0.88A 2izqA-4dccA:
undetectable
2izqB-4dccA:
undetectable		 2izqA-4dccA:
5.63
2izqB-4dccA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A  90
ILE A  18
ASN A  19
LEU A  96
PHE A 127
 None
 1.27A 3ay0B-4dccA:
undetectable		 3ay0B-4dccA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 GLN A  52
GLU A  54
THR A 114
HIS A 118
 None
None
UNL  A 304 ( 3.8A)
UNL  A 304 ( 3.8A)
 1.13A 3glqB-4dccA:
undetectable		 3glqB-4dccA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A 200
ALA A 196
VAL A  16
 None
 0.93A 3l8lA-4dccA:
undetectable
3l8lB-4dccA:
undetectable		 3l8lA-4dccA:
5.63
3l8lB-4dccA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  77
LYS A  78
ASP A  81
 None
 0.79A 4a7tA-4dccA:
undetectable		 4a7tA-4dccA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  91
PHE A 127
THR A 114
LEU A 143
LEU A 110
 None
None
UNL  A 304 ( 3.8A)
None
None
 0.91A 4km2A-4dccA:
undetectable		 4km2A-4dccA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A  12
GLY A  14
ASP A 175
PHE A 157
PHE A 173
 NA  A 302 ( 3.0A)
CL  A 301 ( 3.6A)
NA  A 302 ( 4.3A)
None
None
 1.38A 4wh5A-4dccA:
undetectable		 4wh5A-4dccA:
23.22