SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 PHE A 208
GLY A 236
GLY A 238
ASN A 305
PRO A 307
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
0.27A 1nv8A-4dcmA:
16.9
1nv8A-4dcmA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 PHE A 208
GLY A 236
GLY A 238
ILE A 242
PRO A 307
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-4.7A)
SAM  A 401 (-4.0A)
0.48A 1nv8B-4dcmA:
17.0
1nv8B-4dcmA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
6 / 12 PHE A 208
GLY A 238
ILE A 242
SER A 261
ASN A 305
PRO A 307
SAM  A 401 (-3.6A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-4.7A)
None
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
0.55A 1sg9A-4dcmA:
17.3
1sg9A-4dcmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
6 / 12 PHE A 208
GLY A 236
GLY A 238
ILE A 242
SER A 261
PRO A 307
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-4.7A)
None
SAM  A 401 (-4.0A)
0.49A 1sg9B-4dcmA:
17.1
1sg9B-4dcmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 PHE A 208
GLY A 238
SER A 261
ASN A 305
PRO A 307
SAM  A 401 (-3.6A)
SAM  A 401 ( 3.7A)
None
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
0.37A 1sg9C-4dcmA:
17.2
1sg9C-4dcmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
3 / 3 GLY A 236
ASP A 259
ASN A 305
SAM  A 401 (-3.5A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.8A)
0.27A 1vq1A-4dcmA:
17.1
1vq1A-4dcmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 PHE A 208
GLY A 236
GLY A 238
ILE A 242
PRO A 307
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-4.7A)
SAM  A 401 (-4.0A)
0.54A 1vq1B-4dcmA:
17.1
1vq1B-4dcmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 9 GLY A  56
ALA A  57
SER A  59
LEU A  58
LEU A  36
None
1.16A 1y7iA-4dcmA:
2.3
1y7iA-4dcmA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
3 / 3 TRP A  28
LEU A  58
LYS A 113
None
1.19A 1yajK-4dcmA:
undetectable
1yajK-4dcmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
6 / 12 PHE A 208
ASP A 234
LEU A 235
GLY A 236
GLY A 238
ASN A 305
SAM  A 401 (-3.6A)
SAM  A 401 ( 4.2A)
None
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-3.8A)
0.37A 2nxeB-4dcmA:
14.0
2nxeB-4dcmA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
4 / 8 ASP A 316
LYS A 316
TYR A 346
PRO A 307
None
None
None
SAM  A 401 (-4.0A)
1.00A 2ys6A-4dcmA:
undetectable
2ys6A-4dcmA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 PHE A 208
LEU A 235
GLY A 236
GLY A 238
ASN A 305
SAM  A 401 (-3.6A)
None
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-3.8A)
0.38A 2zbpA-4dcmA:
13.6
2zbpA-4dcmA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
6 / 12 PHE A 208
GLY A 236
GLY A 238
ASN A 305
PRO A 307
VAL A 318
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
None
0.74A 2zulA-4dcmA:
33.7
2zulA-4dcmA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 PHE A 297
GLY A 334
ASN A 300
ALA A 301
VAL A 302
PEG  A 402 ( 4.8A)
PEG  A 403 ( 4.8A)
PEG  A 403 ( 4.1A)
None
None
0.93A 3av6A-4dcmA:
8.1
3av6A-4dcmA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 GLY A 240
GLY A 238
ILE A 232
LEU A 303
GLY A 243
None
SAM  A 401 ( 3.7A)
None
None
None
0.83A 3axzA-4dcmA:
undetectable
3axzA-4dcmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
3 / 3 GLY A 238
ASP A 259
SER A 261
SAM  A 401 ( 3.7A)
SAM  A 401 (-2.9A)
None
0.66A 3brfA-4dcmA:
undetectable
3brfA-4dcmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 ASP A 234
LEU A 235
GLY A 236
VAL A 241
ASP A 259
SAM  A 401 ( 4.2A)
None
SAM  A 401 (-3.5A)
None
SAM  A 401 (-2.9A)
0.42A 3cjtC-4dcmA:
13.8
3cjtC-4dcmA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
6 / 12 PHE A 208
GLY A 236
GLY A 238
ASN A 305
PRO A 307
VAL A 318
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
None
0.79A 3dmfA-4dcmA:
33.9
3dmfA-4dcmA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
6 / 12 PHE A 208
GLY A 236
GLY A 238
ASN A 305
PRO A 307
VAL A 318
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
None
0.75A 3dmhA-4dcmA:
34.0
3dmhA-4dcmA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 11 GLY A 236
GLY A 238
ASP A 259
ALA A 290
GLU A 321
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-2.9A)
SAM  A 401 (-4.2A)
SAM  A 401 ( 4.9A)
0.82A 3g88A-4dcmA:
14.2
3g88A-4dcmA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 11 GLY A 236
GLY A 238
ASP A 259
ALA A 290
GLU A 321
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-2.9A)
SAM  A 401 (-4.2A)
SAM  A 401 ( 4.9A)
0.83A 3g88B-4dcmA:
14.1
3g88B-4dcmA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 GLY A 236
GLY A 238
ASP A 259
ALA A 290
GLU A 321
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-2.9A)
SAM  A 401 (-4.2A)
SAM  A 401 ( 4.9A)
0.82A 3g89A-4dcmA:
14.2
3g89A-4dcmA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 11 GLY A 236
GLY A 238
ASP A 259
ALA A 290
GLU A 321
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-2.9A)
SAM  A 401 (-4.2A)
SAM  A 401 ( 4.9A)
0.81A 3g89B-4dcmA:
14.1
3g89B-4dcmA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 GLY A 236
GLY A 238
ASP A 259
ALA A 290
GLU A 321
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-2.9A)
SAM  A 401 (-4.2A)
SAM  A 401 ( 4.9A)
0.81A 3g8bA-4dcmA:
14.1
3g8bA-4dcmA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 GLY A 236
GLY A 238
ASP A 259
ALA A 290
GLU A 321
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-2.9A)
SAM  A 401 (-4.2A)
SAM  A 401 ( 4.9A)
0.77A 3g8bB-4dcmA:
13.4
3g8bB-4dcmA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 GLY A 236
ILE A 242
ASP A 259
ASN A 305
PRO A 307
SAM  A 401 (-3.5A)
SAM  A 401 (-4.7A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
0.34A 3q87B-4dcmA:
12.3
3q87B-4dcmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
4 / 6 GLY A  56
ASN A  83
LEU A  13
GLU A  29
None
1.00A 3zqtA-4dcmA:
undetectable
3zqtA-4dcmA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
11 / 11 PHE A 208
ALA A 217
ASP A 234
GLY A 236
GLY A 238
ILE A 242
ASP A 259
GLU A 260
ASN A 289
ASN A 305
PRO A 307
SAM  A 401 (-3.6A)
SAM  A 401 (-3.2A)
SAM  A 401 ( 4.2A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-4.7A)
SAM  A 401 (-2.9A)
None
SAM  A 401 (-4.3A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
0.04A 4dcmA-4dcmA:
60.9
4dcmA-4dcmA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
6 / 11 PHE A 208
ALA A 217
GLY A 236
GLY A 238
ASN A 288
ASN A 305
SAM  A 401 (-3.6A)
SAM  A 401 (-3.2A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
None
SAM  A 401 (-3.8A)
1.28A 4dcmA-4dcmA:
60.9
4dcmA-4dcmA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 GLY A 236
GLY A 238
ILE A 242
ASN A 305
PRO A 307
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-4.7A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
0.51A 4gc9A-4dcmA:
7.5
4gc9A-4dcmA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 LEU A 244
GLY A 243
LEU A 224
MET A 221
VAL A 339
None
1.31A 4okxA-4dcmA:
undetectable
4okxA-4dcmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
4 / 6 ASN A 250
GLU A 335
TYR A 337
LEU A 224
None
1.24A 4twdB-4dcmA:
undetectable
4twdC-4dcmA:
undetectable
4twdB-4dcmA:
21.12
4twdC-4dcmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
4 / 6 ASN A 250
GLU A 335
TYR A 337
LEU A 224
None
1.27A 4twdD-4dcmA:
undetectable
4twdE-4dcmA:
undetectable
4twdD-4dcmA:
21.12
4twdE-4dcmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 GLY A 240
GLY A 238
ILE A 232
LEU A 303
GLY A 243
None
SAM  A 401 ( 3.7A)
None
None
None
0.83A 4yvgA-4dcmA:
undetectable
4yvgA-4dcmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 SER A 261
GLY A 236
GLY A 238
SER A  73
ILE A  75
None
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
None
None
1.07A 4yvgA-4dcmA:
undetectable
4yvgA-4dcmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
3 / 3 GLY A 238
ASP A 259
ASN A 289
SAM  A 401 ( 3.7A)
SAM  A 401 (-2.9A)
SAM  A 401 (-4.3A)
0.50A 5jglA-4dcmA:
17.7
5jglA-4dcmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
4 / 7 ASN A 206
SER A  99
ILE A  70
LEU A 120
None
0.96A 5u4sA-4dcmA:
7.1
5u4sA-4dcmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
4 / 8 ASN A 206
SER A  99
ILE A  70
LEU A 120
None
0.97A 5u4sB-4dcmA:
6.0
5u4sB-4dcmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 GLY A 240
GLY A 238
ILE A 232
LEU A 303
GLY A 243
None
SAM  A 401 ( 3.7A)
None
None
None
0.90A 5zhmB-4dcmA:
undetectable
5zhmB-4dcmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
5 / 12 LEU A 128
VAL A 158
PRO A 115
LEU A  51
TYR A 103
None
1.43A 6eliA-4dcmA:
undetectable
6eliA-4dcmA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli)
4 / 5 ILE A 147
THR A 151
THR A 165
LEU A  35
None
1.03A 6f3mD-4dcmA:
6.6
6f3mD-4dcmA:
22.77