SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 12 ALA A  31
GLY A 356
ILE A 355
THR A  88
ILE A  70
 None
 0.89A 1fb7A-4dd5A:
undetectable		 1fb7A-4dd5A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 11 ALA A  31
GLY A 356
ILE A 355
THR A  88
ILE A  70
 None
 0.91A 1ohrA-4dd5A:
undetectable		 1ohrA-4dd5A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 11 SER A 104
VAL A 263
LEU A 261
LEU A 392
LEU A 363
 None
 1.13A 2a15A-4dd5A:
undetectable		 2a15A-4dd5A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		3 / 3 GLY A  20
GLU A 222
ASP A 256
 None
 0.69A 2b25B-4dd5A:
undetectable		 2b25B-4dd5A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 9 LEU A  62
ILE A 355
GLY A 356
GLY A 119
SER A 124
 None
 0.98A 2qmmA-4dd5A:
undetectable		 2qmmA-4dd5A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 12 GLY A 352
SER A 252
ALA A 348
ASN A 321
GLY A  96
 None
 1.09A 2vmyB-4dd5A:
undetectable		 2vmyB-4dd5A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 5 ARG A  16
ASP A 221
ILE A 224
GLU A 203
 None
 1.01A 2xrzA-4dd5A:
undetectable
2xrzB-4dd5A:
undetectable		 2xrzA-4dd5A:
22.00
2xrzB-4dd5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		3 / 3 SER A 124
GLY A  24
GLY A  20
 None
 0.39A 3bogA-4dd5A:
undetectable
3bogC-4dd5A:
undetectable		 3bogA-4dd5A:
undetectable
3bogC-4dd5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 6 GLY A  60
GLY A 119
GLY A  96
GLY A 356
GLY A 359
 None
 0.88A 3bogB-4dd5A:
undetectable
3bogD-4dd5A:
undetectable		 3bogB-4dd5A:
undetectable
3bogD-4dd5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 8 GLY A 118
GLY A 119
GLY A 356
SER A  99
 None
 0.70A 3d41A-4dd5A:
undetectable		 3d41A-4dd5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 12 GLY A  94
GLY A 119
GLY A  59
LEU A  57
ALA A 360
 None
 0.96A 3kkzB-4dd5A:
undetectable		 3kkzB-4dd5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		3 / 3 VAL A 100
SER A 104
LEU A 392
 None
 0.67A 3n8xA-4dd5A:
undetectable		 3n8xA-4dd5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 10 ALA A  42
ILE A  89
LEU A  58
ILE A 107
ILE A 280
 None
 1.16A 3prsA-4dd5A:
undetectable		 3prsA-4dd5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		6 / 12 GLY A 257
VAL A 218
GLY A 118
ALA A 259
ALA A  15
ALA A  42
 None
 1.47A 3sudD-4dd5A:
undetectable		 3sudD-4dd5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 12 VAL A 208
GLY A 119
ALA A  15
ALA A  14
SER A  13
 None
 0.91A 3sudD-4dd5A:
undetectable		 3sudD-4dd5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 12 VAL A 208
GLY A 119
ALA A 258
ALA A  15
SER A  13
 None
 0.98A 3sudD-4dd5A:
undetectable		 3sudD-4dd5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 224
SER A 124
ALA A  25
LEU A  34
VAL A  29
 None
 1.10A 3w67C-4dd5A:
undetectable		 3w67C-4dd5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 9 GLY A 387
GLY A 386
PHE A 157
ASN A 158
GLY A 287
 None
 1.09A 3ztvA-4dd5A:
undetectable		 3ztvA-4dd5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 10 ASN A 343
GLU A 322
ASP A 221
GLU A 203
GLY A 359
 None
 1.39A 4evyA-4dd5A:
0.0
4evyB-4dd5A:
0.0		 4evyA-4dd5A:
18.25
4evyB-4dd5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 12 LEU A 363
LEU A 367
ILE A  11
GLY A 378
LEU A 392
 None
 0.96A 4lmnA-4dd5A:
undetectable		 4lmnA-4dd5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 12 ALA A 348
SER A 252
ILE A  91
GLY A 359
GLU A 319
 None
 1.02A 4r29D-4dd5A:
undetectable		 4r29D-4dd5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 5 GLY A 389
ALA A 286
GLY A 296
PRO A 297
 None
 0.95A 4u9uA-4dd5A:
undetectable		 4u9uA-4dd5A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 5 ALA A 286
LYS A 303
THR A 390
THR A 391
 None
 1.36A 4w5oA-4dd5A:
undetectable		 4w5oA-4dd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 6 ALA A 286
LYS A 303
THR A 390
THR A 391
 None
 1.34A 4w5qA-4dd5A:
undetectable		 4w5qA-4dd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 6 ALA A 286
LYS A 303
THR A 390
THR A 391
 None
 1.35A 4w5tA-4dd5A:
undetectable		 4w5tA-4dd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 6 ALA A 286
LYS A 303
THR A 390
THR A 391
 None
 1.37A 4z4cA-4dd5A:
undetectable		 4z4cA-4dd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 5 ALA A 286
LYS A 303
THR A 390
THR A 391
 None
 1.34A 4z4dA-4dd5A:
undetectable		 4z4dA-4dd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 5 ALA A 286
LYS A 303
THR A 390
THR A 391
 None
 1.35A 4z4eA-4dd5A:
undetectable		 4z4eA-4dd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 6 ALA A 286
LYS A 303
THR A 390
THR A 391
 None
 1.34A 4z4fA-4dd5A:
undetectable		 4z4fA-4dd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 9 ARG A  98
LEU A  97
LEU A 261
ILE A  11
ALA A 103
 None
 1.42A 4z69A-4dd5A:
undetectable		 4z69A-4dd5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 9 ARG A  98
LEU A 392
LEU A 261
ILE A  11
ALA A 103
 None
 1.21A 4z69A-4dd5A:
undetectable		 4z69A-4dd5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 5 ALA A  12
ALA A  46
ILE A 274
LEU A 272
 None
 0.62A 5jncD-4dd5A:
undetectable		 5jncD-4dd5A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		4 / 8 LEU A 183
ILE A 292
TRP A 173
GLN A 172
 None
 0.94A 5ljbA-4dd5A:
undetectable		 5ljbA-4dd5A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 12 ASP A 155
ILE A 156
GLY A 387
SER A 154
VAL A  92
 None
 0.78A 5twjC-4dd5A:
undetectable		 5twjC-4dd5A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 9 VAL A  32
ALA A  31
SER A  30
VAL A  36
GLY A 257
 None
 1.06A 6bklA-4dd5A:
undetectable
6bklB-4dd5A:
undetectable
6bklC-4dd5A:
undetectable
6bklD-4dd5A:
undetectable		 6bklA-4dd5A:
4.55
6bklB-4dd5A:
4.55
6bklC-4dd5A:
4.55
6bklD-4dd5A:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		 4dd5 ACETYL-COA
ACETYLTRANSFERASE
(Clostridioides
difficile) 		5 / 10 SER A 358
ASN A 321
HIS A 353
GLU A 319
GLU A 203
 None
 1.37A 6cggB-4dd5A:
0.0		 6cggB-4dd5A:
20.49