SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ddd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		4 / 8 GLY A 168
TRP A 169
GLY A 165
VAL A 147
 None
 0.91A 1dbbH-4dddA:
undetectable
1dbbL-4dddA:
undetectable		 1dbbH-4dddA:
21.30
1dbbL-4dddA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		5 / 12 VAL A 263
LEU A 262
SER A 261
GLY A  35
LEU A  78
 None
 1.07A 1pxxC-4dddA:
undetectable		 1pxxC-4dddA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GKZ_A_B40A500_1
(ANTI-METHAMPHETAMINE
SINGLE CHAIN FV)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		5 / 11 TYR A 237
SER A  93
TYR A 236
GLU A 124
TYR A  43
 None
None
None
None
GOL  A 405 (-3.8A)
 1.30A 3gkzA-4dddA:
undetectable		 3gkzA-4dddA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GM0_A_B41A600_1
(ANTI-METHAMPHETAMINE
SINGLE CHAIN FV)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		5 / 11 TYR A 237
SER A  93
TYR A 236
GLU A 124
TYR A  43
 None
None
None
None
GOL  A 405 (-3.8A)
 1.31A 3gm0A-4dddA:
0.0		 3gm0A-4dddA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		4 / 7 GLY A 202
TYR A  43
GLY A  41
THR A  40
 None
GOL  A 405 (-3.8A)
GOL  A 405 ( 3.8A)
None
 0.81A 3tajA-4dddA:
8.5		 3tajA-4dddA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		4 / 5 GLY A 202
PRO A 204
ASN A 205
TYR A 247
 None
 1.04A 3u8qA-4dddA:
8.7		 3u8qA-4dddA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		4 / 8 ASP A  94
ASN A 148
GLU A 179
ASP A 199
 None
 1.04A 4feuD-4dddA:
undetectable		 4feuD-4dddA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQP_H_B40H1201_1
(ANTI-METH SCFV)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		5 / 11 TYR A 237
SER A  93
TYR A 236
GLU A 124
TYR A  43
 None
None
None
None
GOL  A 405 (-3.8A)
 1.33A 4gqpH-4dddA:
0.0		 4gqpH-4dddA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAR_L_1WEL300_1
(SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
SINGLE LIGHT CHAIN
VARIABLE FRAGMENT)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		5 / 10 TYR A 237
SER A  93
TYR A 236
GLU A 124
TYR A  43
 None
None
None
None
GOL  A 405 (-3.8A)
 1.31A 4larH-4dddA:
0.0
4larL-4dddA:
0.0		 4larH-4dddA:
19.59
4larL-4dddA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		5 / 12 GLU A  30
ILE A  34
LEU A 262
SER A 269
ILE A  32
 None
 1.15A 4o1eA-4dddA:
undetectable		 4o1eA-4dddA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		5 / 12 GLU A  30
ILE A  34
LEU A 262
SER A 269
ILE A  32
 None
 1.13A 4o1eB-4dddA:
undetectable		 4o1eB-4dddA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		6 / 12 VAL A 263
LEU A 262
SER A 261
LEU A  33
GLY A  35
LEU A  78
 None
 1.46A 4rrwD-4dddA:
undetectable		 4rrwD-4dddA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		6 / 12 VAL A 263
LEU A 262
SER A 261
LEU A  33
GLY A  35
LEU A  78
 None
 1.46A 4rrzD-4dddA:
undetectable		 4rrzD-4dddA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		5 / 9 VAL A 263
LEU A 262
SER A 261
GLY A  35
LEU A  78
 None
 0.98A 4rs0A-4dddA:
undetectable		 4rs0A-4dddA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		5 / 12 SER A 182
ASP A 199
PRO A 152
SER A  38
ARG A 157
 None
None
None
GOL  A 405 (-4.3A)
None
 1.15A 4uroA-4dddA:
undetectable		 4uroA-4dddA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		4 / 4 LEU A 163
TYR A 125
PRO A 221
ILE A 220
 None
EDO  A 403 ( 4.3A)
None
None
 1.25A 5esgA-4dddA:
undetectable		 5esgA-4dddA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		3 / 3 ASN A 205
SER A 182
SER A 183
 None
 0.77A 5gsnA-4dddA:
undetectable		 5gsnA-4dddA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ddd IMMUNOGENIC PROTEIN
(Ehrlichia
chaffeensis) 		3 / 3 TYR A 237
TYR A  43
SER A  74
 None
GOL  A 405 (-3.8A)
CL  A 401 (-3.2A)
 0.95A 5iktB-4dddA:
undetectable		 5iktB-4dddA:
19.08