SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ddi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		4 / 6 LEU A1171
THR A1167
PHE A1162
LEU A1047
 None
 1.07A 2wm3A-4ddiA:
undetectable		 2wm3A-4ddiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		5 / 11 ILE A  99
LEU A  86
LEU A 103
ILE A 106
PRO A  65
 None
 1.05A 3a50B-4ddiA:
undetectable		 3a50B-4ddiA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		4 / 7 TYR A1235
VAL A1056
ILE A1072
ARG A1083
 None
 1.02A 3mssB-4ddiA:
undetectable		 3mssB-4ddiA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		4 / 7 TYR A1261
VAL A1056
ILE A1072
ARG A1083
 None
 1.07A 3mssB-4ddiA:
undetectable		 3mssB-4ddiA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		5 / 12 ILE A  99
LEU A  86
LEU A 103
ILE A 106
PRO A  65
 None
 1.02A 3vrmA-4ddiA:
undetectable		 3vrmA-4ddiA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		4 / 5 LEU A1175
GLY A1097
ILE A1231
VAL A1257
 None
 0.82A 3wriA-4ddiA:
undetectable		 3wriA-4ddiA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		4 / 5 LEU A1175
GLY A1097
ILE A1231
VAL A1257
 None
 0.84A 3wriB-4ddiA:
undetectable		 3wriB-4ddiA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		4 / 5 LEU A1175
GLY A1097
ILE A1231
VAL A1257
 None
 0.89A 3wrkA-4ddiA:
undetectable		 3wrkA-4ddiA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		5 / 12 SER A1121
ALA A1226
PHE A1114
VAL A1257
LEU A1104
 None
 1.03A 5tudD-4ddiA:
undetectable		 5tudD-4ddiA:
21.49