SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ddw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 8 CYH A  32
CYH A  11
GLY A  15
GLY A  16
 ZN  A1202 (-2.3A)
ZN  A1202 (-2.3A)
None
None
 0.84A 1ekjA-4ddwA:
3.6
1ekjB-4ddwA:
3.7		 1ekjA-4ddwA:
11.10
1ekjB-4ddwA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 8 CYH A  32
CYH A  11
GLY A  15
GLY A  16
 ZN  A1202 (-2.3A)
ZN  A1202 (-2.3A)
None
None
 0.84A 1ekjG-4ddwA:
3.7
1ekjH-4ddwA:
3.9		 1ekjG-4ddwA:
11.10
1ekjH-4ddwA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 8 GLN A 741
LEU A 749
LEU A1056
LEU A1100
 None
 1.26A 1hk2A-4ddwA:
undetectable		 1hk2A-4ddwA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 ARG A 931
ILE A 859
TRP A 885
 None
 1.20A 1m8eB-4ddwA:
undetectable		 1m8eB-4ddwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 ARG A 931
ILE A 859
TRP A 885
 None
 1.03A 1nodB-4ddwA:
undetectable		 1nodB-4ddwA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 ARG A 931
ILE A 859
TRP A 885
 None
 1.07A 1qomA-4ddwA:
undetectable		 1qomA-4ddwA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 12 LEU A 455
LEU A 393
ALA A 398
LEU A 403
VAL A 406
 None
 1.15A 1s9pD-4ddwA:
undetectable		 1s9pD-4ddwA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 10 LEU A1056
LYS A1057
VAL A 763
LEU A 740
TYR A1055
 None
 1.37A 1sv5A-4ddwA:
undetectable		 1sv5A-4ddwA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 8 PHE A 437
PHE A 445
ALA A 404
LEU A 424
 None
 0.99A 1x8vA-4ddwA:
undetectable		 1x8vA-4ddwA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 8 ARG A 446
GLY A 447
THR A 500
ILE A 900
 None
 0.94A 2f9wA-4ddwA:
2.6
2f9wB-4ddwA:
2.4		 2f9wA-4ddwA:
13.67
2f9wB-4ddwA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 12 LEU A  85
ILE A 656
VAL A 573
VAL A 582
LEU A 281
 None
 1.13A 2g78A-4ddwA:
undetectable		 2g78A-4ddwA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 ARG A 931
ILE A 859
TRP A 885
 None
 0.99A 2nodB-4ddwA:
undetectable		 2nodB-4ddwA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 5 LEU A 457
ALA A 398
LEU A 403
MET A 444
 None
 1.25A 2oaxA-4ddwA:
undetectable		 2oaxA-4ddwA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 12 GLY A 673
THR A 667
GLU A 672
ILE A 546
ASP A 679
 None
 1.03A 2oxtC-4ddwA:
undetectable		 2oxtC-4ddwA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 10 GLU A 512
ILE A 510
ARG A 292
ASP A 491
GLU A 492
 None
 1.47A 2qeoB-4ddwA:
0.0		 2qeoB-4ddwA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 7 ALA A 468
GLY A 470
ARG A 286
PHE A 308
 None
 0.75A 2wq5A-4ddwA:
undetectable		 2wq5A-4ddwA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 12 ILE A  90
VAL A  91
PHE A 199
THR A 113
MET A  98
 None
 1.35A 3a8iC-4ddwA:
undetectable		 3a8iC-4ddwA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DYE_A_LNRA600_1
(D7 PROTEIN)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 9 GLU A 512
ILE A 510
ARG A 292
ASP A 491
GLU A 492
 None
 1.46A 3dyeA-4ddwA:
0.0		 3dyeA-4ddwA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 ARG A 931
ILE A 859
TRP A 885
 None
 1.16A 3e68A-4ddwA:
undetectable		 3e68A-4ddwA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 ARG A 931
ILE A 859
TRP A 885
 None
 1.15A 3e6tB-4ddwA:
undetectable		 3e6tB-4ddwA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 ARG A 931
ILE A 859
TRP A 885
 None
 1.11A 3e7iB-4ddwA:
undetectable		 3e7iB-4ddwA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 9 ALA A 145
ASP A 146
LEU A 117
VAL A 179
ILE A 151
 None
 1.13A 3em4B-4ddwA:
undetectable		 3em4B-4ddwA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 4 LEU A  33
PRO A  28
LEU A  45
ARG A  43
 None
 1.24A 3hcoB-4ddwA:
undetectable		 3hcoB-4ddwA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 4 GLY A 322
VAL A 361
GLY A 385
THR A 386
 None
 0.76A 3ib2A-4ddwA:
undetectable		 3ib2A-4ddwA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 ASP A 670
ARG A 853
ARG A 693
 None
 1.00A 3k37A-4ddwA:
undetectable		 3k37A-4ddwA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 10 VAL A1035
PHE A1002
ILE A 762
ALA A1005
VAL A 758
 None
 1.05A 3me6A-4ddwA:
undetectable		 3me6A-4ddwA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 ARG A 931
ILE A 859
TRP A 885
 None
 1.00A 3nw2A-4ddwA:
undetectable		 3nw2A-4ddwA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 ARG A 931
ILE A 859
TRP A 885
 None
 0.98A 3nw2B-4ddwA:
undetectable		 3nw2B-4ddwA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 LYS A1024
ARG A 853
ASP A 594
 None
 1.42A 3o7wA-4ddwA:
undetectable		 3o7wA-4ddwA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 TYR A 593
ASP A 645
ASP A 633
 None
 0.63A 3ou6B-4ddwA:
3.6		 3ou6B-4ddwA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 12 SER A 212
ILE A 265
LEU A 218
ASN A 214
LEU A 274
 None
 1.22A 3q87B-4ddwA:
2.3		 3q87B-4ddwA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 10 LEU A 829
ILE A 825
ALA A 821
VAL A1008
VAL A1026
 None
 1.16A 3r9cA-4ddwA:
undetectable		 3r9cA-4ddwA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 7 ILE A 900
LEU A 504
GLU A 911
GLU A 907
 None
 0.88A 3r9tB-4ddwA:
undetectable		 3r9tB-4ddwA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 12 GLY A  81
ARG A 701
GLY A 478
THR A 578
ALA A 285
 None
 1.08A 3sugA-4ddwA:
undetectable		 3sugA-4ddwA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 6 HIS A   9
SER A 617
ASP A 623
ASP A 645
 None
 1.26A 4blvA-4ddwA:
2.5		 4blvA-4ddwA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 10 ARG A 589
ILE A 571
ILE A 656
ALA A 652
VAL A 592
 None
 1.11A 4kq8A-4ddwA:
undetectable		 4kq8A-4ddwA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 11 GLY A 478
LEU A 480
GLY A 579
ILE A 510
LEU A 498
 None
 1.00A 4kt0A-4ddwA:
undetectable
4kt0J-4ddwA:
undetectable		 4kt0A-4ddwA:
19.45
4kt0J-4ddwA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 TYR A  57
ARG A 654
SER A 687
 None
 1.18A 4lf7I-4ddwA:
undetectable
4lf7J-4ddwA:
undetectable		 4lf7I-4ddwA:
7.96
4lf7J-4ddwA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		3 / 3 TYR A  57
ARG A 654
SER A 687
 None
 1.18A 4lf8I-4ddwA:
undetectable
4lf8J-4ddwA:
undetectable		 4lf8I-4ddwA:
7.96
4lf8J-4ddwA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 6 SER A 528
GLU A 527
VAL A 484
THR A 289
 None
 1.28A 4lnxA-4ddwA:
undetectable		 4lnxA-4ddwA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 11 ARG A 725
VAL A1026
ILE A1007
THR A1021
ILE A1025
 None
 0.98A 4njvC-4ddwA:
undetectable		 4njvC-4ddwA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 8 ILE A 293
LEU A 313
LEU A 305
ILE A 357
 None
 0.80A 4r38A-4ddwA:
undetectable		 4r38A-4ddwA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 12 GLU A 845
ILE A 849
ALA A1023
HIS A 921
ASP A 842
 None
 0.83A 4v01A-4ddwA:
undetectable		 4v01A-4ddwA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 8 GLY A 863
GLN A 864
PHE A 932
SER A 935
 None
 0.96A 4ws1A-4ddwA:
2.4		 4ws1A-4ddwA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 6 LEU A 248
ASN A 247
PRO A 245
ARG A 230
 None
 1.44A 4yv5A-4ddwA:
undetectable		 4yv5A-4ddwA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 7 LEU A 653
THR A 681
LEU A 684
THR A 588
 None
 0.87A 4z90A-4ddwA:
undetectable
4z90B-4ddwA:
undetectable
4z90C-4ddwA:
undetectable
4z90D-4ddwA:
undetectable
4z90E-4ddwA:
undetectable		 4z90A-4ddwA:
15.62
4z90B-4ddwA:
15.62
4z90C-4ddwA:
15.62
4z90D-4ddwA:
15.62
4z90E-4ddwA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 12 ARG A 589
ILE A 571
ILE A 656
ALA A 652
VAL A 592
 None
 1.12A 5jkvA-4ddwA:
undetectable		 5jkvA-4ddwA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 12 LEU A 329
ILE A 359
GLY A 337
LEU A 305
ASN A 356
 None
 0.97A 5nfjC-4ddwA:
2.5		 5nfjC-4ddwA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 4 VAL A 525
LYS A 482
VAL A 291
ASN A 517
 None
 1.31A 5vc3A-4ddwA:
undetectable		 5vc3A-4ddwA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 6 GLU A 808
GLU A 807
ALA A 806
LYS A 944
 None
 0.82A 6an0A-4ddwA:
undetectable		 6an0A-4ddwA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 12 PHE A 109
PHE A 199
VAL A  91
PHE A  67
VAL A 254
 None
 1.19A 6ap6B-4ddwA:
2.2		 6ap6B-4ddwA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		4 / 6 GLN A 864
GLU A 862
ALA A 867
GLN A 936
 None
 1.47A 6f6jC-4ddwA:
undetectable
6f6jD-4ddwA:
undetectable		 6f6jC-4ddwA:
16.79
6f6jD-4ddwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4ddw REVERSE GYRASE
(Thermotoga
maritima) 		5 / 11 ALA A 258
VAL A 278
PHE A 270
ILE A 215
LEU A 209
 None
 1.03A 6h1lB-4ddwA:
undetectable		 6h1lB-4ddwA:
18.09