SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4de8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		5 / 11 LEU A 302
LEU A 299
SER A 295
ALA A 269
THR A 265
 None
 0.98A 1tz8A-4de8A:
undetectable
1tz8B-4de8A:
undetectable		 1tz8A-4de8A:
16.11
1tz8B-4de8A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 6 ALA A 267
SER A 245
ASN A 248
ILE A 249
 None
 0.90A 1yc2A-4de8A:
undetectable		 1yc2A-4de8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.14A 1zzrA-4de8A:
undetectable
1zzrB-4de8A:
undetectable		 1zzrA-4de8A:
22.51
1zzrB-4de8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 PHE A 360
GLU A 335
VAL A 347
VAL A 350
 None
 1.15A 1zzrA-4de8A:
undetectable
1zzrB-4de8A:
undetectable		 1zzrA-4de8A:
22.51
1zzrB-4de8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.13A 1zzuA-4de8A:
undetectable
1zzuB-4de8A:
undetectable		 1zzuA-4de8A:
22.51
1zzuB-4de8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 PHE A 360
GLU A 335
VAL A 347
VAL A 350
 None
 1.16A 1zzuA-4de8A:
1.8
1zzuB-4de8A:
undetectable		 1zzuA-4de8A:
22.51
1zzuB-4de8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		5 / 11 VAL A 328
ILE A 322
LEU A 325
LEU A 386
LEU A 389
 None
None
None
0K3  A 501 (-3.5A)
0K3  A 501 (-4.5A)
 1.15A 2a15A-4de8A:
undetectable		 2a15A-4de8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 4 SER A 245
GLY A 232
HIS A 297
ASP A 306
 None
0K3  A 501 ( 3.9A)
None
None
 1.14A 2oxtC-4de8A:
undetectable		 2oxtC-4de8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 8 TYR A 303
GLN A 475
MET A 478
ILE A 474
 None
 1.07A 2xytE-4de8A:
undetectable		 2xytE-4de8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 8 TYR A 303
GLN A 475
MET A 478
ILE A 474
 None
 1.02A 2xytH-4de8A:
undetectable		 2xytH-4de8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 TYR A 303
GLN A 475
MET A 478
ILE A 474
 None
 1.04A 2xytI-4de8A:
undetectable		 2xytI-4de8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 6 TYR A 167
LEU A 114
VAL A 161
VAL A 133
 None
 0.98A 2z97A-4de8A:
undetectable		 2z97A-4de8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.15A 3dqrA-4de8A:
undetectable
3dqrB-4de8A:
undetectable		 3dqrA-4de8A:
22.32
3dqrB-4de8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 PHE A 360
GLU A 335
VAL A 347
VAL A 350
 None
 1.20A 3dqrA-4de8A:
undetectable
3dqrB-4de8A:
undetectable		 3dqrA-4de8A:
22.32
3dqrB-4de8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.16A 3jx2A-4de8A:
undetectable
3jx2B-4de8A:
undetectable		 3jx2A-4de8A:
22.32
3jx2B-4de8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 PHE A 360
GLU A 335
VAL A 347
VAL A 350
 None
 1.19A 3jx2A-4de8A:
undetectable
3jx2B-4de8A:
undetectable		 3jx2A-4de8A:
22.32
3jx2B-4de8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.17A 3jx3A-4de8A:
undetectable
3jx3B-4de8A:
undetectable		 3jx3A-4de8A:
22.32
3jx3B-4de8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.18A 3jx5A-4de8A:
undetectable
3jx5B-4de8A:
2.0		 3jx5A-4de8A:
22.32
3jx5B-4de8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.17A 3jx6A-4de8A:
undetectable
3jx6B-4de8A:
1.9		 3jx6A-4de8A:
22.17
3jx6B-4de8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 TYR A 398
VAL A 230
VAL A 413
ILE A 409
 None
 1.04A 3mssB-4de8A:
undetectable		 3mssB-4de8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.16A 3nljA-4de8A:
2.0
3nljB-4de8A:
undetectable		 3nljA-4de8A:
22.17
3nljB-4de8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 PHE A 360
GLU A 335
VAL A 347
VAL A 350
 None
 1.16A 3nljA-4de8A:
2.0
3nljB-4de8A:
undetectable		 3nljA-4de8A:
22.17
3nljB-4de8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 8 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.15A 3nlqA-4de8A:
undetectable
3nlqB-4de8A:
undetectable		 3nlqA-4de8A:
22.32
3nlqB-4de8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 PHE A 360
GLU A 335
VAL A 347
VAL A 350
 None
 1.16A 3nlqA-4de8A:
undetectable
3nlqB-4de8A:
undetectable		 3nlqA-4de8A:
22.32
3nlqB-4de8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 6 TYR A 303
GLN A 475
MET A 478
ILE A 474
 None
 1.20A 3pmzD-4de8A:
undetectable		 3pmzD-4de8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 6 TYR A 398
VAL A 230
VAL A 413
ILE A 409
 None
 1.04A 3pyyA-4de8A:
undetectable		 3pyyA-4de8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		5 / 12 LEU A 405
SER A 317
ILE A 401
ALA A 394
LEU A 325
 None
 1.17A 3vw1B-4de8A:
undetectable		 3vw1B-4de8A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		5 / 12 ILE A 385
GLN A 379
SER A 231
VAL A 230
ILE A 228
 0K3  A 501 ( 4.2A)
None
None
None
None
 1.00A 4ax8A-4de8A:
undetectable		 4ax8A-4de8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 TYR A 167
LEU A 114
VAL A 161
VAL A 133
 None
 0.98A 4cp4A-4de8A:
undetectable		 4cp4A-4de8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.17A 4cx3A-4de8A:
1.6
4cx3B-4de8A:
undetectable		 4cx3A-4de8A:
22.32
4cx3B-4de8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		4 / 7 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.17A 4cx4A-4de8A:
1.6
4cx4B-4de8A:
undetectable		 4cx4A-4de8A:
22.32
4cx4B-4de8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		3 / 3 LYS A 152
ASN A 126
ASP A 158
 None
 0.75A 4o1eA-4de8A:
undetectable		 4o1eA-4de8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4de8 CPS2A
(Streptococcus
pneumoniae) 		5 / 12 GLY A 291
ILE A 191
ASN A 190
TYR A 450
ASP A 275
 None
 1.05A 4rtsA-4de8A:
undetectable		 4rtsA-4de8A:
21.41