SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4de9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4de9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR YWTF
(Bacillus
subtilis) 		5 / 10 HIS A 205
VAL A 177
VAL A 179
ALA A 214
ILE A 190
 None
 1.03A 1likA-4de9A:
undetectable		 1likA-4de9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4de9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR YWTF
(Bacillus
subtilis) 		4 / 5 VAL A 102
LEU A  78
LEU A 235
ILE A 278
 None
VTP  A 401 ( 4.5A)
VTP  A 401 (-3.7A)
VTP  A 401 (-4.9A)
 0.95A 4a9jC-4de9A:
undetectable		 4a9jC-4de9A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4de9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR YWTF
(Bacillus
subtilis) 		4 / 4 VAL A 145
THR A 147
GLU A 149
GLU A 150
 None
 1.36A 4l78A-4de9A:
undetectable		 4l78A-4de9A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4de9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR YWTF
(Bacillus
subtilis) 		5 / 12 GLU A 161
HIS A 136
PHE A 132
SER A  96
GLY A  80
 None
None
None
None
VTP  A 401 ( 4.0A)
 1.41A 4olfA-4de9A:
undetectable		 4olfA-4de9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 4de9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR YWTF
(Bacillus
subtilis) 		4 / 6 ARG A 227
ARG A  95
ASP A  97
ASP A 119
 VTP  A 401 (-2.4A)
None
VTP  A 401 (-3.8A)
None
 1.06A 4xqeA-4de9A:
undetectable		 4xqeA-4de9A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4de9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR YWTF
(Bacillus
subtilis) 		4 / 6 ARG A 227
ARG A  95
ASP A  97
ASP A 119
 VTP  A 401 (-2.4A)
None
VTP  A 401 (-3.8A)
None
 1.07A 4xqeB-4de9A:
undetectable		 4xqeB-4de9A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4de9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR YWTF
(Bacillus
subtilis) 		4 / 8 ARG A 227
ARG A  95
ASP A  97
ASP A 119
 VTP  A 401 (-2.4A)
None
VTP  A 401 (-3.8A)
None
 1.08A 4xqgA-4de9A:
undetectable		 4xqgA-4de9A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4de9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR YWTF
(Bacillus
subtilis) 		4 / 8 ARG A 227
ARG A  95
ASP A  97
ASP A 119
 VTP  A 401 (-2.4A)
None
VTP  A 401 (-3.8A)
None
 1.07A 4xqgB-4de9A:
undetectable		 4xqgB-4de9A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4de9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR YWTF
(Bacillus
subtilis) 		4 / 4 THR A 147
LEU A 143
HIS A 127
GLY A 140
 None
 1.21A 5gwyA-4de9A:
undetectable		 5gwyA-4de9A:
22.26