SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4deq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4deq NEUROPILIN-1,
VASCULAR ENDOTHELIAL
GROWTH FACTOR A
(Homo
sapiens) 		4 / 5 ASP A 158
SER A 160
LEU A 126
GLY A 163
 None
 1.12A 2j2pA-4deqA:
undetectable
2j2pB-4deqA:
undetectable		 2j2pA-4deqA:
20.00
2j2pB-4deqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 4deq NEUROPILIN-1,
VASCULAR ENDOTHELIAL
GROWTH FACTOR A
(Homo
sapiens) 		5 / 9 VAL A 118
GLY A  67
ILE A 133
TYR A  85
GLY A 110
 None
 1.25A 3csjB-4deqA:
undetectable		 3csjB-4deqA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4deq NEUROPILIN-1,
VASCULAR ENDOTHELIAL
GROWTH FACTOR A
(Homo
sapiens) 		5 / 12 ILE A  13
VAL A  66
VAL A  63
ILE A  99
VAL A  89
 None
 1.26A 3iw1A-4deqA:
undetectable		 3iw1A-4deqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4deq NEUROPILIN-1,
VASCULAR ENDOTHELIAL
GROWTH FACTOR A
(Homo
sapiens) 		5 / 12 ILE A  99
PHE A  62
VAL A  63
SER A  91
VAL A 131
 None
 1.20A 3iw1A-4deqA:
undetectable		 3iw1A-4deqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4deq NEUROPILIN-1,
VASCULAR ENDOTHELIAL
GROWTH FACTOR A
(Homo
sapiens) 		3 / 3 GLU A  51
GLY A  45
SER A  48
 None
 0.69A 4b53B-4deqA:
undetectable		 4b53B-4deqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4deq NEUROPILIN-1,
VASCULAR ENDOTHELIAL
GROWTH FACTOR A
(Homo
sapiens) 		3 / 3 ARG A  61
ILE A 127
PHE A  62
 None
 0.75A 5kirA-4deqA:
undetectable		 5kirA-4deqA:
16.61