SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
4 / 8 GLN A 149
TYR A 110
ASP A 234
VAL A 237
None
0.91A 1ekjA-4dezA:
undetectable
1ekjB-4dezA:
undetectable
1ekjA-4dezA:
19.89
1ekjB-4dezA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
4 / 6 GLN A 149
TYR A 110
ASP A 234
VAL A 237
None
0.90A 1ekjC-4dezA:
undetectable
1ekjD-4dezA:
undetectable
1ekjC-4dezA:
19.89
1ekjD-4dezA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
4 / 6 ASP A 234
VAL A 237
GLN A 149
TYR A 110
None
0.88A 1ekjC-4dezA:
undetectable
1ekjD-4dezA:
undetectable
1ekjC-4dezA:
19.89
1ekjD-4dezA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
4 / 8 GLN A 149
TYR A 110
ASP A 234
VAL A 237
None
0.86A 1ekjE-4dezA:
undetectable
1ekjF-4dezA:
undetectable
1ekjE-4dezA:
19.89
1ekjF-4dezA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
4 / 7 ALA A 154
THR A 155
ALA A 158
ARG A 129
None
0.82A 2ql8A-4dezA:
undetectable
2ql8B-4dezA:
undetectable
2ql8A-4dezA:
18.55
2ql8B-4dezA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
4 / 4 LYS A 230
LEU A 226
ALA A 229
LEU A 225
None
1.29A 2roxA-4dezA:
undetectable
2roxA-4dezA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 10 LEU A 166
GLY A 232
ASP A 234
GLY A 185
VAL A 186
None
1.00A 3oxwA-4dezA:
undetectable
3oxwA-4dezA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.37A 4qvlV-4dezA:
undetectable
4qvlb-4dezA:
undetectable
4qvlV-4dezA:
20.33
4qvlb-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.37A 4qvlH-4dezA:
undetectable
4qvlN-4dezA:
undetectable
4qvlH-4dezA:
20.33
4qvlN-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.35A 4qvmV-4dezA:
undetectable
4qvmb-4dezA:
undetectable
4qvmV-4dezA:
20.33
4qvmb-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.35A 4qvmH-4dezA:
undetectable
4qvmN-4dezA:
undetectable
4qvmH-4dezA:
20.33
4qvmN-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.35A 4qvpV-4dezA:
undetectable
4qvpb-4dezA:
undetectable
4qvpV-4dezA:
20.33
4qvpb-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.35A 4qvpH-4dezA:
undetectable
4qvpN-4dezA:
undetectable
4qvpH-4dezA:
20.33
4qvpN-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.36A 4qvqV-4dezA:
undetectable
4qvqb-4dezA:
undetectable
4qvqV-4dezA:
20.33
4qvqb-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.36A 4qvqH-4dezA:
undetectable
4qvqN-4dezA:
undetectable
4qvqH-4dezA:
20.33
4qvqN-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.38A 4qvwV-4dezA:
undetectable
4qvwb-4dezA:
undetectable
4qvwV-4dezA:
20.33
4qvwb-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.38A 4qvwH-4dezA:
undetectable
4qvwN-4dezA:
undetectable
4qvwH-4dezA:
20.33
4qvwN-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.36A 4qw0V-4dezA:
undetectable
4qw0b-4dezA:
undetectable
4qw0V-4dezA:
20.33
4qw0b-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.36A 4qw0H-4dezA:
undetectable
4qw0N-4dezA:
undetectable
4qw0H-4dezA:
20.33
4qw0N-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.36A 4qw1V-4dezA:
undetectable
4qw1b-4dezA:
undetectable
4qw1V-4dezA:
20.33
4qw1b-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.35A 4qw1H-4dezA:
undetectable
4qw1N-4dezA:
undetectable
4qw1H-4dezA:
20.33
4qw1N-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.37A 4qw3V-4dezA:
undetectable
4qw3b-4dezA:
undetectable
4qw3V-4dezA:
20.33
4qw3b-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.36A 4qw3H-4dezA:
undetectable
4qw3N-4dezA:
undetectable
4qw3H-4dezA:
20.33
4qw3N-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.36A 4qwuV-4dezA:
undetectable
4qwub-4dezA:
undetectable
4qwuV-4dezA:
20.33
4qwub-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.36A 4qwuH-4dezA:
undetectable
4qwuN-4dezA:
undetectable
4qwuH-4dezA:
20.33
4qwuN-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
6 / 12 ALA A 158
GLU A 126
VAL A 142
ALA A 154
LEU A 115
ASP A 120
None
1.40A 4v01B-4dezA:
undetectable
4v01B-4dezA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
3 / 3 VAL A  17
TYR A  83
ALA A  86
None
0.53A 4ybnA-4dezA:
undetectable
4ybnA-4dezA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.36A 5bxnV-4dezA:
undetectable
5bxnb-4dezA:
undetectable
5bxnV-4dezA:
20.33
5bxnb-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.36A 5bxnH-4dezA:
undetectable
5bxnN-4dezA:
undetectable
5bxnH-4dezA:
20.33
5bxnN-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.36A 5cz7H-4dezA:
undetectable
5cz7N-4dezA:
undetectable
5cz7H-4dezA:
20.33
5cz7N-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.37A 5d0xV-4dezA:
undetectable
5d0xb-4dezA:
undetectable
5d0xV-4dezA:
20.33
5d0xb-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.37A 5d0xH-4dezA:
undetectable
5d0xN-4dezA:
undetectable
5d0xH-4dezA:
20.33
5d0xN-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.37A 5l66V-4dezA:
undetectable
5l66b-4dezA:
undetectable
5l66V-4dezA:
20.33
5l66b-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.37A 5l66H-4dezA:
undetectable
5l66N-4dezA:
undetectable
5l66H-4dezA:
20.33
5l66N-4dezA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 12 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.38A 5lf3b-4dezA:
undetectable
5lf3b-4dezA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)
4dez DNA POLYMERASE IV 1
(Mycolicibacteriu
m
smegmatis)
5 / 12 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
None
1.40A 5lf3N-4dezA:
undetectable
5lf3N-4dezA:
21.02