SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4df1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A   7
ILE A 176
GLY A 178
ALA A  10
LEU A  11
 None
BMP  A 301 ( 4.6A)
BMP  A 301 (-3.4A)
BMP  A 301 ( 3.9A)
None
 1.03A 1cqeA-4df1A:
undetectable		 1cqeA-4df1A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A   7
ILE A 176
GLY A 178
ALA A  10
LEU A  11
 None
BMP  A 301 ( 4.6A)
BMP  A 301 (-3.4A)
BMP  A 301 ( 3.9A)
None
 1.03A 1cqeB-4df1A:
undetectable		 1cqeB-4df1A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		4 / 7 LEU A  11
VAL A  29
TYR A  53
GLY A  31
 None
 0.99A 1lweA-4df1A:
undetectable		 1lweA-4df1A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A   7
ILE A 176
GLY A 178
ALA A  10
LEU A  11
 None
BMP  A 301 ( 4.6A)
BMP  A 301 (-3.4A)
BMP  A 301 ( 3.9A)
None
 1.05A 2aylB-4df1A:
undetectable		 2aylB-4df1A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A  76
LEU A  60
VAL A  34
SER A  45
GLY A  43
 None
 1.06A 2vmyA-4df1A:
undetectable		 2vmyA-4df1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A   7
ILE A 176
GLY A 178
ALA A  10
LEU A  11
 None
BMP  A 301 ( 4.6A)
BMP  A 301 (-3.4A)
BMP  A 301 ( 3.9A)
None
 1.18A 3n8xA-4df1A:
undetectable		 3n8xA-4df1A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A   7
ILE A 176
GLY A 178
ALA A  10
LEU A  11
 None
BMP  A 301 ( 4.6A)
BMP  A 301 (-3.4A)
BMP  A 301 ( 3.9A)
None
 1.06A 3n8zB-4df1A:
undetectable		 3n8zB-4df1A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 9 GLY A  80
ALA A  81
ILE A  57
ILE A  46
LEU A  76
 None
 1.01A 3ogpA-4df1A:
undetectable		 3ogpA-4df1A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		4 / 4 ILE A 153
SER A 154
ASP A  59
ASP A  37
 None
None
BMP  A 301 (-3.8A)
None
 1.45A 4krhB-4df1A:
undetectable		 4krhB-4df1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		4 / 8 LEU A  11
ALA A  28
VAL A  34
TYR A  53
 None
 0.96A 5nu7A-4df1A:
undetectable		 5nu7A-4df1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 10 PRO A 202
ILE A  85
VAL A   8
LEU A   7
GLU A 175
 None
 1.42A 5tixB-4df1A:
undetectable		 5tixB-4df1A:
18.68