SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4df3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 12 PHE A 129
ARG A  80
GLY A 103
ILE A  99
LEU A  62
 None
 1.19A 1kglA-4df3A:
undetectable		 1kglA-4df3A:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		7 / 12 LYS A  61
TYR A  83
GLY A  85
ALA A  87
SER A  88
ALA A 135
ASP A 154
 SAM  A 301 ( 3.9A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
 0.67A 1nt2A-4df3A:
28.1		 1nt2A-4df3A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		8 / 12 TYR A  83
GLY A  85
ALA A  87
SER A  88
THR A  91
ALA A 135
ASP A 154
GLN A 157
 SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 0.72A 1nt2A-4df3A:
28.1		 1nt2A-4df3A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		3 / 3 THR A  90
GLU A 109
ASP A 134
 SAM  A 301 (-3.9A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
 0.46A 1nt2A-4df3A:
28.1		 1nt2A-4df3A:
44.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 12 TYR A  83
GLY A  85
GLY A  89
VAL A 155
ALA A 156
 SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-4.3A)
SAM  A 301 ( 4.2A)
 0.58A 1vptA-4df3A:
8.4		 1vptA-4df3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		3 / 3 GLY A  85
GLU A 109
ASP A 154
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.6A)
 0.26A 2b25B-4df3A:
14.1		 2b25B-4df3A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		3 / 3 VAL A   2
GLU A  22
GLU A   3
 None
 0.80A 2nv4A-4df3A:
undetectable		 2nv4A-4df3A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 11 LEU A  66
VAL A 215
TYR A 177
TYR A 228
LEU A  73
 None
 1.36A 3bgrA-4df3A:
undetectable
3bgrB-4df3A:
undetectable		 3bgrA-4df3A:
16.10
3bgrB-4df3A:
16.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 11 LYS A  61
THR A  90
GLU A 109
ASP A 134
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-3.9A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.8A)
 1.30A 3id5B-4df3A:
32.3		 3id5B-4df3A:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		8 / 11 LYS A  61
TYR A  83
GLY A  85
GLU A 109
ASP A 134
ALA A 135
ASP A 154
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 0.53A 3id5B-4df3A:
32.3		 3id5B-4df3A:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		8 / 11 LYS A  61
TYR A  83
GLY A  85
THR A  91
ASP A 134
ALA A 135
ASP A 154
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 0.70A 3id5B-4df3A:
32.3		 3id5B-4df3A:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 11 TYR A 152
THR A  91
ALA A 135
ASP A 154
GLN A 157
 None
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 1.35A 3id5B-4df3A:
32.3		 3id5B-4df3A:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 11 LYS A  61
THR A  90
GLU A 109
ASP A 134
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-3.9A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.8A)
 1.30A 3id5F-4df3A:
32.2		 3id5F-4df3A:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		8 / 11 LYS A  61
TYR A  83
GLY A  85
GLU A 109
ASP A 134
ALA A 135
ASP A 154
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 0.53A 3id5F-4df3A:
32.2		 3id5F-4df3A:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		8 / 11 LYS A  61
TYR A  83
GLY A  85
THR A  91
ASP A 134
ALA A 135
ASP A 154
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 0.70A 3id5F-4df3A:
32.2		 3id5F-4df3A:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 11 TYR A 152
THR A  91
ALA A 135
ASP A 154
GLN A 157
 None
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 1.35A 3id5F-4df3A:
32.2		 3id5F-4df3A:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		9 / 12 TYR A  83
GLY A  85
ALA A  87
THR A  91
GLU A 109
ASP A 134
ALA A 135
ASP A 154
GLN A 157
 SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 0.43A 3id6C-4df3A:
32.4		 3id6C-4df3A:
53.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 4 GLY A  85
GLU A 109
ASP A 134
ASP A 154
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.6A)
 0.32A 3mb5A-4df3A:
17.4		 3mb5A-4df3A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 8 GLU A 109
SER A  88
MET A 115
VAL A 121
 SAM  A 301 (-2.9A)
None
None
None
 1.32A 3nlyA-4df3A:
undetectable
3nlyB-4df3A:
undetectable		 3nlyA-4df3A:
19.58
3nlyB-4df3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		8 / 12 LYS A  61
GLY A  85
ALA A  87
GLU A 109
ASP A 134
ALA A 135
ASP A 154
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 0.51A 3nmuA-4df3A:
undetectable
3nmuF-4df3A:
32.9		 3nmuA-4df3A:
22.65
3nmuF-4df3A:
53.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		6 / 11 GLY A  85
ALA A  87
GLU A 109
ALA A 135
ASP A 154
GLN A 157
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
 0.41A 3nmuB-4df3A:
undetectable
3nmuJ-4df3A:
32.8		 3nmuB-4df3A:
22.65
3nmuJ-4df3A:
53.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		8 / 12 LYS A  61
GLY A  85
ALA A  87
ASP A 134
ALA A 135
ASP A 154
VAL A 155
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.8A)
 0.71A 3nvkI-4df3A:
32.5		 3nvkI-4df3A:
53.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		6 / 12 ALA A  87
GLU A 109
PHE A 110
ASP A 134
ALA A 135
GLN A 157
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.8A)
 1.03A 3nvkF-4df3A:
undetectable
3nvkJ-4df3A:
32.4		 3nvkF-4df3A:
22.53
3nvkJ-4df3A:
53.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		8 / 12 GLY A  85
ALA A  87
GLU A 109
ASP A 134
ALA A 135
ASP A 154
VAL A 155
GLN A 157
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.8A)
 0.69A 3nvkF-4df3A:
undetectable
3nvkJ-4df3A:
32.4		 3nvkF-4df3A:
22.53
3nvkJ-4df3A:
53.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 8 GLU A 109
SER A  88
MET A 115
VAL A 121
 SAM  A 301 (-2.9A)
None
None
None
 1.31A 3rqlA-4df3A:
undetectable
3rqlB-4df3A:
undetectable		 3rqlA-4df3A:
19.58
3rqlB-4df3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 5 SER A  88
THR A  90
GLU A 109
ASP A 134
 None
SAM  A 301 (-3.9A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
 0.48A 3tm4A-4df3A:
8.1		 3tm4A-4df3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 5 SER A  88
THR A  90
GLU A 109
ASP A 134
 None
SAM  A 301 (-3.9A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
 0.45A 3tm4B-4df3A:
8.1		 3tm4B-4df3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		3 / 3 ARG A 104
PHE A 129
PRO A 130
 None
 0.67A 3zoaB-4df3A:
undetectable		 3zoaB-4df3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 8 GLU A 109
SER A  88
MET A 115
VAL A 121
 SAM  A 301 (-2.9A)
None
None
None
 1.33A 4capA-4df3A:
undetectable
4capB-4df3A:
undetectable		 4capA-4df3A:
19.58
4capB-4df3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 8 GLU A 109
SER A  88
MET A 115
VAL A 121
 SAM  A 301 (-2.9A)
None
None
None
 1.37A 4d32A-4df3A:
undetectable
4d32B-4df3A:
undetectable		 4d32A-4df3A:
19.58
4d32B-4df3A:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 12 ALA A  87
THR A  91
PHE A 110
ASP A 134
GLN A 157
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.8A)
 1.32A 4df3A-4df3A:
44.5		 4df3A-4df3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		12 / 12 LYS A  61
GLY A  85
ALA A  87
THR A  90
PHE A 110
ALA A 111
VAL A 114
ASP A 134
ALA A 135
ASP A 154
VAL A 155
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
SAM  A 301 ( 3.9A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.8A)
 0.00A 4df3A-4df3A:
44.5		 4df3A-4df3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		3 / 3 TYR A  83
THR A  91
GLU A 109
 SAM  A 301 (-4.5A)
SAM  A 301 (-3.3A)
SAM  A 301 (-2.9A)
 0.02A 4df3A-4df3A:
44.5		 4df3A-4df3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 12 ALA A  87
THR A  91
PHE A 110
ASP A 134
GLN A 157
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.8A)
 1.29A 4df3B-4df3A:
42.0		 4df3B-4df3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		12 / 12 LYS A  61
GLY A  85
ALA A  87
THR A  90
PHE A 110
ALA A 111
VAL A 114
ASP A 134
ALA A 135
ASP A 154
VAL A 155
GLN A 157
 SAM  A 301 ( 3.9A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
SAM  A 301 ( 3.9A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.8A)
 0.15A 4df3B-4df3A:
42.0		 4df3B-4df3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		3 / 3 TYR A  83
THR A  91
GLU A 109
 SAM  A 301 (-4.5A)
SAM  A 301 (-3.3A)
SAM  A 301 (-2.9A)
 0.09A 4df3B-4df3A:
42.0		 4df3B-4df3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 10 HIS A  10
ILE A  98
TRP A  55
LEU A  67
LEU A  66
 None
 1.43A 4jq4B-4df3A:
undetectable		 4jq4B-4df3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 8 GLU A 109
SER A  88
MET A 115
VAL A 121
 SAM  A 301 (-2.9A)
None
None
None
 1.31A 4v3yA-4df3A:
undetectable
4v3yB-4df3A:
undetectable		 4v3yA-4df3A:
19.58
4v3yB-4df3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 7 GLY A  85
GLU A 109
ASP A 134
ASP A 154
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.6A)
 0.37A 5ergB-4df3A:
12.8		 5ergB-4df3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 12 ASP A 134
ALA A 135
SER A  88
THR A  90
GLU A 109
 SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
None
SAM  A 301 (-3.9A)
SAM  A 301 (-2.9A)
 0.63A 5hfjD-4df3A:
4.0		 5hfjD-4df3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 12 ALA A 135
ASP A 154
SER A  88
THR A  90
GLU A 109
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
None
SAM  A 301 (-3.9A)
SAM  A 301 (-2.9A)
 1.30A 5hfjE-4df3A:
4.0		 5hfjE-4df3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 12 ASP A 134
ALA A 135
SER A  88
THR A  90
GLU A 109
 SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
None
SAM  A 301 (-3.9A)
SAM  A 301 (-2.9A)
 0.79A 5hfjE-4df3A:
4.0		 5hfjE-4df3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 12 ASP A 134
ALA A 135
ASP A 154
SER A  88
GLU A 109
 SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
None
SAM  A 301 (-2.9A)
 0.98A 5hfjF-4df3A:
4.1		 5hfjF-4df3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 7 GLY A  85
GLU A 109
ALA A 111
ASP A 134
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.3A)
 0.43A 5mvsA-4df3A:
9.9		 5mvsA-4df3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 8 GLY A  85
GLU A 109
ALA A 111
ASP A 134
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.3A)
 0.38A 5mvsB-4df3A:
9.9		 5mvsB-4df3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 12 PHE A 171
PHE A 170
ASN A 167
LEU A  82
VAL A 145
 None
 1.12A 5tudD-4df3A:
undetectable		 5tudD-4df3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		4 / 8 SER A  88
MET A 115
VAL A 121
GLU A 109
 None
None
None
SAM  A 301 (-2.9A)
 1.31A 5uo7A-4df3A:
undetectable
5uo7B-4df3A:
undetectable		 5uo7A-4df3A:
19.91
5uo7B-4df3A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 12 GLY A  85
VAL A 114
ASP A 134
ALA A 135
ALA A 156
 SAM  A 301 (-3.4A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 4.2A)
 0.93A 6bq4A-4df3A:
12.7		 6bq4A-4df3A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Aeropyrum
pernix) 		5 / 12 GLY A  85
VAL A 114
ASP A 134
ALA A 135
ALA A 156
 SAM  A 301 (-3.4A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 4.2A)
 0.94A 6bq4B-4df3A:
12.7		 6bq4B-4df3A:
16.44