SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4df9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		4 / 8 ILE A 128
LEU A 130
PHE A  95
GLY A  39
 None
 0.96A 1os6A-4df9A:
undetectable		 1os6A-4df9A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 12 PHE A 422
ILE A 416
PHE A 317
ILE A 176
HIS A  63
 None
None
None
None
GOL  A 507 (-4.1A)
 1.14A 1ot7A-4df9A:
undetectable		 1ot7A-4df9A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 12 VAL A 310
PHE A 313
ILE A 416
VAL A 178
ILE A 420
 None
 0.72A 1r5lA-4df9A:
undetectable		 1r5lA-4df9A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		4 / 7 TYR A 423
HIS A 276
TYR A 292
ILE A 416
 None
 1.19A 1tuvA-4df9A:
undetectable		 1tuvA-4df9A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		3 / 3 ILE A 278
ASP A 196
PHE A 193
 None
 0.63A 1uwjB-4df9A:
undetectable		 1uwjB-4df9A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 12 PHE A 193
ALA A 221
LEU A 269
ILE A 277
ILE A 278
 None
 1.04A 1xdkB-4df9A:
undetectable		 1xdkB-4df9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		4 / 7 VAL A 380
GLY A 379
THR A 364
ASP A 358
 None
 0.97A 2a1mA-4df9A:
undetectable		 2a1mA-4df9A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 11 PRO A 118
GLU A 275
ILE A 176
ASP A 177
ALA A  58
 None
NA  A 501 (-3.0A)
None
NA  A 501 (-3.3A)
NA  A 501 (-4.3A)
 1.36A 2admA-4df9A:
undetectable		 2admA-4df9A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 12 THR A 129
GLY A  71
ILE A  46
GLN A  96
PHE A  37
 None
 0.90A 2akeA-4df9A:
undetectable		 2akeA-4df9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 12 THR A 129
GLY A  71
ILE A  46
GLN A  96
PHE A  37
 None
 0.91A 2azxA-4df9A:
undetectable		 2azxA-4df9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 12 THR A 129
GLY A  71
ILE A  46
GLN A  96
PHE A  37
 None
 0.91A 2azxB-4df9A:
undetectable		 2azxB-4df9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 12 HIS A 311
GLU A 312
HIS A 315
TYR A 326
TYR A 324
 ZN  A 502 ( 3.2A)
2PE  A 504 (-4.1A)
ZN  A 502 (-3.3A)
2PE  A 504 (-4.1A)
2PE  A 504 (-3.8A)
 0.94A 2c6nA-4df9A:
2.8		 2c6nA-4df9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		3 / 3 THR A 361
PRO A 365
TYR A 376
 None
 0.88A 2dxrA-4df9A:
undetectable		 2dxrA-4df9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		4 / 8 MET A 190
PHE A 193
ALA A 281
LEU A 280
 None
 1.04A 2o01A-4df9A:
undetectable		 2o01A-4df9A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		3 / 3 PHE A 313
PHE A 210
PHE A 205
 None
 0.85A 2od9A-4df9A:
undetectable		 2od9A-4df9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		3 / 3 PHE A 313
PHE A 210
PHE A 205
 None
 0.85A 2qqgA-4df9A:
undetectable		 2qqgA-4df9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		3 / 3 HIS A 311
GLU A 312
HIS A 315
 ZN  A 502 ( 3.2A)
2PE  A 504 (-4.1A)
ZN  A 502 (-3.3A)
 0.18A 3kecB-4df9A:
5.7		 3kecB-4df9A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 10 THR A 250
LEU A 297
GLU A 312
LEU A  94
PHE A 251
 None
None
2PE  A 504 (-4.1A)
None
None
 1.46A 3tbgC-4df9A:
undetectable		 3tbgC-4df9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		3 / 3 ARG A 261
PRO A 225
PHE A 244
 PO4  A 505 (-3.2A)
None
None
 0.84A 3thrC-4df9A:
undetectable		 3thrC-4df9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		4 / 7 ILE A 128
LEU A 130
PHE A  95
GLY A  39
 None
 0.79A 4hbfA-4df9A:
undetectable		 4hbfA-4df9A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		4 / 7 ILE A 128
LEU A 130
PHE A  95
GLY A  39
 None
 0.91A 4hc3A-4df9A:
undetectable		 4hc3A-4df9A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		4 / 7 LEU A 320
ARG A 414
PRO A  68
SER A  90
 None
 1.26A 4klrA-4df9A:
4.0		 4klrA-4df9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		4 / 7 PRO A 341
TYR A 324
GLU A 323
TYR A 386
 None
2PE  A 504 (-3.8A)
ZN  A 503 (-2.5A)
2PE  A 504 (-3.9A)
 1.10A 4lb2A-4df9A:
undetectable		 4lb2A-4df9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 12 LEU A  51
LEU A  31
ILE A  33
ILE A  75
VAL A 126
 None
 0.89A 4y0sA-4df9A:
undetectable		 4y0sA-4df9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		3 / 3 ARG A  60
PRO A  68
ASN A 293
 None
 1.08A 5jwaA-4df9A:
2.4
5jwaH-4df9A:
2.4		 5jwaA-4df9A:
22.47
5jwaH-4df9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 12 THR A 299
THR A 298
ALA A 300
SER A 232
THR A 242
 None
 1.20A 5lf7V-4df9A:
undetectable
5lf7b-4df9A:
undetectable		 5lf7V-4df9A:
19.80
5lf7b-4df9A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 10 MET A 190
PHE A 193
ALA A 281
LEU A 280
LEU A 116
 None
 1.26A 5oy01-4df9A:
undetectable
5oy07-4df9A:
undetectable		 5oy01-4df9A:
13.86
5oy07-4df9A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 12 LEU A 269
ILE A 272
GLY A 271
LEU A 181
VAL A 222
 None
 1.12A 5twjC-4df9A:
undetectable		 5twjC-4df9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 12 PHE A 217
ILE A 176
PHE A 205
PHE A 313
ALA A 197
 None
 1.15A 5vcgA-4df9A:
undetectable		 5vcgA-4df9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4df9 PUTATIVE PEPTIDASE
(Bacteroides
fragilis) 		5 / 10 VAL A 145
LEU A  31
LEU A 117
LEU A  48
LEU A  51
 None
 0.98A 6f5uA-4df9A:
1.8
6f5uB-4df9A:
undetectable		 6f5uA-4df9A:
11.40
6f5uB-4df9A:
11.37