SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4dfc UVRABC SYSTEM
PROTEIN A
(Escherichia
coli) 		5 / 12 LEU B 245
LEU B 151
LEU B 150
MET B 149
LEU B 148
 None
 0.95A 2ouzA-4dfcB:
undetectable		 2ouzA-4dfcB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_D_GLYD73_0
(NONSTRUCTURAL
PROTEIN 1)		 4dfc TRANSCRIPTION-REPAIR
-COUPLING FACTOR
UVRABC SYSTEM
PROTEIN A
(Escherichia
coli;
Escherichia
coli) 		4 / 4 ARG B 216
ASP A 139
SER A 137
ARG A 138
 None
 1.28A 2z0aC-4dfcB:
undetectable
2z0aD-4dfcB:
undetectable		 2z0aC-4dfcB:
24.60
2z0aD-4dfcB:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4dfc UVRABC SYSTEM
PROTEIN A
(Escherichia
coli) 		5 / 12 ALA B 224
LEU B 166
LEU B 169
ILE B 154
LEU B 225
 None
 1.03A 3hecA-4dfcB:
undetectable		 3hecA-4dfcB:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4dfc TRANSCRIPTION-REPAIR
-COUPLING FACTOR
UVRABC SYSTEM
PROTEIN A
(Escherichia
coli;
Escherichia
coli) 		4 / 5 LEU A 168
ARG A 193
ARG B 176
THR B 223
 None
 1.22A 4p3qA-4dfcA:
undetectable		 4p3qA-4dfcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4dfc TRANSCRIPTION-REPAIR
-COUPLING FACTOR
UVRABC SYSTEM
PROTEIN A
(Escherichia
coli;
Escherichia
coli) 		6 / 11 LEU B 150
GLY A 166
VAL B 202
THR B 223
GLU B 226
ALA B 224
 None
 1.43A 5o96G-4dfcB:
undetectable		 5o96G-4dfcB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4dfc UVRABC SYSTEM
PROTEIN A
(Escherichia
coli) 		5 / 9 LEU B 150
SER B 220
PHE B 221
LEU B 225
VAL B 139
 None
 1.39A 6ftpA-4dfcB:
undetectable
6ftpB-4dfcB:
undetectable		 6ftpA-4dfcB:
20.47
6ftpB-4dfcB:
15.20