SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		4 / 8 ALA A  72
ASP A  84
ILE A  83
ILE A 110
 None
 0.87A 1p7lD-4dfeA:
undetectable		 1p7lD-4dfeA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		4 / 8 ALA A  72
ASP A  84
ILE A  83
ILE A 110
 None
 0.85A 1p7lC-4dfeA:
undetectable		 1p7lC-4dfeA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		4 / 8 ALA A  72
ASP A  84
ILE A  83
ILE A 110
 None
 0.89A 1rg9B-4dfeA:
undetectable		 1rg9B-4dfeA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		4 / 8 ALA A  72
ASP A  84
ILE A  83
ILE A 110
 None
 0.88A 1rg9A-4dfeA:
undetectable		 1rg9A-4dfeA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		4 / 8 ALA A  72
ASP A  84
ILE A  83
ILE A 110
 None
 0.87A 1rg9D-4dfeA:
undetectable		 1rg9D-4dfeA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		4 / 8 ALA A  72
ASP A  84
ILE A  83
ILE A 110
 None
 0.86A 1rg9C-4dfeA:
undetectable		 1rg9C-4dfeA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		5 / 11 ILE A 176
ALA A 174
LEU A 104
ILE A  73
ILE A 110
 None
 1.06A 2w9sB-4dfeA:
undetectable		 2w9sB-4dfeA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		4 / 5 GLN A 257
ALA A 295
ILE A 278
ARG A 304
 None
 1.32A 2z0aA-4dfeA:
undetectable		 2z0aA-4dfeA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 240
ALA A 243
SER A 188
GLU A 314
ALA A 236
 None
 1.25A 3axtA-4dfeA:
undetectable		 3axtA-4dfeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		5 / 12 VAL A  88
ALA A 129
ALA A 145
THR A  61
THR A  90
 None
 1.26A 3dl9B-4dfeA:
undetectable		 3dl9B-4dfeA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  12
VAL A  88
ARG A  71
ALA A  68
ALA A  65
 None
 1.11A 3keeB-4dfeA:
undetectable		 3keeB-4dfeA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		4 / 8 ALA A  72
ASP A  84
ILE A  83
ILE A 110
 None
 0.90A 4kttD-4dfeA:
undetectable		 4kttD-4dfeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 323
HIS A 191
ILE A 292
SER A 291
HIS A 256
 None
None
None
None
CSO  A 123 ( 3.7A)
 1.35A 4pooB-4dfeA:
undetectable		 4pooB-4dfeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		5 / 12 HIS A 256
ALA A 258
GLY A 318
GLY A 323
LEU A 232
 CSO  A 123 ( 3.7A)
None
None
None
None
 1.01A 4uilH-4dfeA:
undetectable
4uilL-4dfeA:
undetectable		 4uilH-4dfeA:
22.75
4uilL-4dfeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		4 / 8 ALA A  72
ASP A  84
ILE A  83
ILE A 110
 None
 0.81A 5t8sA-4dfeA:
undetectable		 5t8sA-4dfeA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		3 / 3 THR A  61
THR A 152
ARG A 155
 None
 1.01A 5wm2A-4dfeA:
undetectable		 5wm2A-4dfeA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		4 / 8 VAL A 300
LEU A 296
ILE A 305
ARG A 307
 None
 0.88A 6cb4A-4dfeA:
undetectable		 6cb4A-4dfeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		5 / 9 SER A 188
GLY A 173
SER A  69
VAL A 147
ILE A 148
 None
 1.46A 6giqA-4dfeA:
0.5
6giqE-4dfeA:
undetectable
6giqI-4dfeA:
undetectable		 6giqA-4dfeA:
22.08
6giqE-4dfeA:
21.26
6giqI-4dfeA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Paraburkholderia
xenovorans) 		5 / 9 SER A 325
GLY A 173
SER A  69
VAL A 147
ILE A 148
 None
 1.24A 6giqA-4dfeA:
0.5
6giqE-4dfeA:
undetectable
6giqI-4dfeA:
undetectable		 6giqA-4dfeA:
22.08
6giqE-4dfeA:
21.26
6giqI-4dfeA:
12.74