SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 4dfs GLYCOSIDE HYDROLASE,
FAMILY 16
(Thermotoga
petrophila) 		4 / 4 GLY A 110
LYS A 109
GLY A 140
HIS A 141
 None
 1.10A 1mf1A-4dfsA:
undetectable		 1mf1A-4dfsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4dfs GLYCOSIDE HYDROLASE,
FAMILY 16
(Thermotoga
petrophila) 		3 / 3 ASN A  45
ALA A 227
ASN A 225
 None
 0.67A 1n4fA-4dfsA:
undetectable		 1n4fA-4dfsA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4dfs GLYCOSIDE HYDROLASE,
FAMILY 16
(Thermotoga
petrophila) 		4 / 4 HIS A 179
ASP A 249
ASN A  60
ASP A 177
 None
CA  A 301 (-3.1A)
None
None
 0.91A 1wg8A-4dfsA:
undetectable		 1wg8A-4dfsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4dfs GLYCOSIDE HYDROLASE,
FAMILY 16
(Thermotoga
petrophila) 		3 / 3 HIS A 179
ASP A 249
ASN A  60
 None
CA  A 301 (-3.1A)
None
 0.77A 1wg8B-4dfsA:
undetectable		 1wg8B-4dfsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4dfs GLYCOSIDE HYDROLASE,
FAMILY 16
(Thermotoga
petrophila) 		4 / 6 LEU A 105
MET A 246
GLU A 137
MET A 136
 None
 1.18A 2kuhA-4dfsA:
undetectable		 2kuhA-4dfsA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4dfs GLYCOSIDE HYDROLASE,
FAMILY 16
(Thermotoga
petrophila) 		4 / 7 ASN A  45
TYR A 231
ASN A  34
HIS A  36
 None
 0.98A 3frqB-4dfsA:
undetectable		 3frqB-4dfsA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4dfs GLYCOSIDE HYDROLASE,
FAMILY 16
(Thermotoga
petrophila) 		5 / 12 HIS A 141
LEU A 139
GLY A 230
GLY A 229
ASP A 237
 None
 1.22A 3i5uA-4dfsA:
undetectable		 3i5uA-4dfsA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dfs GLYCOSIDE HYDROLASE,
FAMILY 16
(Thermotoga
petrophila) 		5 / 12 ILE A 248
ALA A 114
ILE A  99
LEU A 222
ILE A 251
 None
 0.89A 4kjjA-4dfsA:
undetectable		 4kjjA-4dfsA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dfs GLYCOSIDE HYDROLASE,
FAMILY 16
(Thermotoga
petrophila) 		5 / 12 ILE A 248
ALA A 114
ILE A  99
LEU A 222
ILE A 251
 None
 0.86A 4pssA-4dfsA:
undetectable		 4pssA-4dfsA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4dfs GLYCOSIDE HYDROLASE,
FAMILY 16
(Thermotoga
petrophila) 		4 / 8 TRP A 112
PRO A 236
GLY A 234
PRO A 233
 None
 1.04A 5kgpB-4dfsA:
undetectable		 5kgpB-4dfsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4dfs GLYCOSIDE HYDROLASE,
FAMILY 16
(Thermotoga
petrophila) 		6 / 12 ILE A  32
ILE A  27
PHE A  30
ILE A  65
LEU A  63
ILE A  23
 None
 1.29A 5mueA-4dfsA:
undetectable		 5mueA-4dfsA:
20.88