SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 10 LEU A 382
ALA A 196
ILE A 222
GLY A 223
GLY A 199
 None
 1.09A 1k6cA-4dg5A:
undetectable		 1k6cA-4dg5A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		4 / 6 SER A  58
THR A 118
LEU A  17
TRP A 139
 None
 1.38A 1mxdA-4dg5A:
undetectable		 1mxdA-4dg5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		4 / 5 PHE A 250
LEU A 264
MET A 226
LEU A 379
 None
 1.42A 1skxA-4dg5A:
undetectable		 1skxA-4dg5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		3 / 3 ILE A 360
ASP A 354
PHE A 324
 None
 0.57A 1uwjB-4dg5A:
undetectable		 1uwjB-4dg5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A 387
GLY A 152
GLY A 374
GLY A 352
LYS A 206
 None
 1.03A 1y4lA-4dg5A:
undetectable		 1y4lA-4dg5A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		4 / 4 GLY A 352
SER A 355
VAL A 316
LEU A 379
 None
 1.36A 1yajB-4dg5A:
undetectable		 1yajB-4dg5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		4 / 6 GLY A 351
SER A 372
LEU A 382
HIS A 370
 None
 0.92A 1yajF-4dg5A:
undetectable		 1yajF-4dg5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		4 / 5 ASP A 296
GLY A 319
VAL A 302
ILE A 297
 None
 0.91A 2aoiA-4dg5A:
undetectable		 2aoiA-4dg5A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		3 / 3 SER A   7
ASP A 149
ASP A 177
 None
 0.78A 2plwA-4dg5A:
undetectable		 2plwA-4dg5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		4 / 7 ILE A 340
THR A 301
ILE A 350
GLY A 322
 None
 0.79A 2v0mB-4dg5A:
undetectable		 2v0mB-4dg5A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_B_TESB340_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 10 ILE A 297
ASN A 318
TRP A 317
VAL A 316
VAL A 315
 None
 1.34A 3burB-4dg5A:
undetectable		 3burB-4dg5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A 304
GLY A 223
ILE A 197
VAL A 263
GLY A 319
 None
 0.91A 3bwcB-4dg5A:
3.1		 3bwcB-4dg5A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 11 PHE A 305
VAL A 263
ILE A 262
LYS A 206
ILE A 210
 None
 1.15A 3o5rA-4dg5A:
undetectable		 3o5rA-4dg5A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 9 GLY A 199
ASP A 205
GLY A 352
ILE A 350
VAL A 209
 None
 1.02A 3u7sB-4dg5A:
undetectable		 3u7sB-4dg5A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		3 / 3 ASP A 367
GLU A 365
GLY A 363
 None
 0.66A 3w9tA-4dg5A:
undetectable		 3w9tA-4dg5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		4 / 5 LEU A 387
ILE A 390
ASN A 188
VAL A 187
 None
 0.95A 4a9kB-4dg5A:
undetectable		 4a9kB-4dg5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 12 ALA A  78
ILE A  44
LEU A 113
VAL A 112
ILE A  48
 None
 1.04A 4aztA-4dg5A:
4.2		 4aztA-4dg5A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A  41
ILE A  47
ASN A 148
VAL A  18
LEU A  56
 None
 1.08A 4fr0A-4dg5A:
undetectable		 4fr0A-4dg5A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 9 VAL A 336
GLU A 308
VAL A 195
ILE A 197
GLY A 223
 None
 1.18A 4fwdA-4dg5A:
undetectable		 4fwdA-4dg5A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 11 PHE A 305
GLY A 225
GLY A 224
GLY A 223
ALA A 201
 None
 1.05A 4l8fB-4dg5A:
3.1		 4l8fB-4dg5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 11 PHE A 305
GLY A 225
GLY A 224
GLY A 223
ALA A 201
 None
 1.06A 4l8fD-4dg5A:
3.1		 4l8fD-4dg5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 10 PHE A 305
VAL A 263
ILE A 262
LYS A 206
ILE A 210
 None
 1.32A 4laxA-4dg5A:
undetectable		 4laxA-4dg5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		3 / 3 PRO A 388
ASN A 161
HIS A 158
 None
 0.93A 4ma3H-4dg5A:
undetectable
4ma3L-4dg5A:
undetectable		 4ma3H-4dg5A:
19.55
4ma3L-4dg5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 12 PHE A 305
VAL A 263
ILE A 262
LYS A 206
ILE A 210
 None
 1.30A 4nnrA-4dg5A:
undetectable
4nnrB-4dg5A:
undetectable		 4nnrA-4dg5A:
17.12
4nnrB-4dg5A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 10 PHE A 305
VAL A 263
ILE A 262
LYS A 206
ILE A 210
 None
 1.24A 4nnrB-4dg5A:
undetectable		 4nnrB-4dg5A:
17.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		7 / 12 GLY A 200
ALA A 201
GLY A 224
GLY A 225
PHE A 274
GLY A 322
VAL A 323
 None
 0.49A 4o33A-4dg5A:
49.5		 4o33A-4dg5A:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		7 / 12 GLY A 200
ALA A 201
GLY A 224
GLY A 225
PHE A 274
GLY A 322
VAL A 323
 None
 0.54A 4o3fA-4dg5A:
47.2		 4o3fA-4dg5A:
44.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		4 / 6 LEU A  81
LEU A 113
VAL A 112
PHE A  91
 None
 1.10A 4uswA-4dg5A:
undetectable		 4uswA-4dg5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_C_QI9C602_0
(CYTOCHROME P450 2D6)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 9 PHE A  22
ASP A  21
VAL A  89
VAL A  77
PHE A  91
 None
 1.44A 4wnvC-4dg5A:
0.0		 4wnvC-4dg5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 12 GLY A 200
GLY A 322
GLY A 352
SER A 355
LEU A 362
 None
 1.09A 5gwxA-4dg5A:
3.8		 5gwxA-4dg5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 10 ALA A  78
LEU A 114
VAL A  89
ILE A  48
ALA A  40
 None
 1.24A 6h1lA-4dg5A:
undetectable		 6h1lA-4dg5A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		5 / 9 ILE A  47
ILE A  48
GLU A 169
VAL A  16
ILE A  54
 None
 1.49A 6hloA-4dg5A:
3.2		 6hloA-4dg5A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4dg5 PHOSPHOGLYCERATE
KINASE
(Staphylococcus
aureus) 		4 / 6 LEU A  26
PRO A  76
TYR A 120
GLU A 116
 None
 0.94A 6pahA-4dg5A:
undetectable		 6pahA-4dg5A:
21.62