SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 206
ALA A 255
LEU A 261
HIS A 298
LEU A 301
 None
 1.18A 1gwrA-4dg8A:
undetectable		 1gwrA-4dg8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		3 / 3 THR A 258
GLU A 451
HIS A 290
 BU3  A 703 (-3.7A)
None
None
 0.88A 1xwfA-4dg8A:
3.5		 1xwfA-4dg8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		3 / 3 THR A 258
GLU A 451
HIS A 290
 BU3  A 703 (-3.7A)
None
None
 0.87A 1xwfB-4dg8A:
3.3		 1xwfB-4dg8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		3 / 3 THR A 258
GLU A 451
HIS A 290
 BU3  A 703 (-3.7A)
None
None
 0.85A 1xwfC-4dg8A:
undetectable		 1xwfC-4dg8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		3 / 3 THR A 258
GLU A 451
HIS A 290
 BU3  A 703 (-3.7A)
None
None
 0.86A 1xwfD-4dg8A:
3.5		 1xwfD-4dg8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 400
GLY A 306
ALA A 363
ILE A 361
 AMP  A 701 (-2.6A)
AMP  A 701 (-4.7A)
None
None
 0.91A 2aofA-4dg8A:
undetectable		 2aofA-4dg8A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 223
TYR A  53
TRP A 221
ILE A 220
 None
 1.15A 2dcfA-4dg8A:
undetectable		 2dcfA-4dg8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 413
GLY A 399
THR A 398
LEU A 344
GLY A 414
 None
 0.98A 2fn1A-4dg8A:
undetectable		 2fn1A-4dg8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 5 TRP A 221
GLY A 228
GLY A 227
PHE A  31
 None
 1.03A 2qr2A-4dg8A:
2.6
2qr2B-4dg8A:
2.7		 2qr2A-4dg8A:
16.29
2qr2B-4dg8A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 283
GLY A 308
THR A 310
ARG A 426
 BU3  A 702 ( 3.1A)
BU3  A 702 (-4.6A)
AMP  A 701 (-3.8A)
AMP  A 701 (-3.1A)
 0.61A 2wd9A-4dg8A:
36.1		 2wd9A-4dg8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 283
GLY A 308
THR A 310
ARG A 426
 BU3  A 702 ( 3.1A)
BU3  A 702 (-4.6A)
AMP  A 701 (-3.8A)
AMP  A 701 (-3.1A)
 0.64A 2wd9B-4dg8A:
37.3		 2wd9B-4dg8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 223
TYR A  53
TRP A 221
ILE A 220
 None
 1.16A 2zm7A-4dg8A:
undetectable		 2zm7A-4dg8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		3 / 3 GLU A  69
SER A 153
VAL A 154
 None
 0.82A 3eeoA-4dg8A:
2.3		 3eeoA-4dg8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQZ_A_LQZA586_1
(SERUM ALBUMIN)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 176
ASP A 375
LYS A 178
ARG A 119
 None
 1.49A 3jqzA-4dg8A:
undetectable		 3jqzA-4dg8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		5 / 9 ILE A 187
CYH A 191
PHE A 196
GLY A 308
PHE A 315
 None
None
None
BU3  A 702 (-4.6A)
None
 1.47A 3ko0A-4dg8A:
undetectable
3ko0C-4dg8A:
undetectable		 3ko0A-4dg8A:
9.40
3ko0C-4dg8A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 308
PHE A 315
ILE A 187
CYH A 191
PHE A 196
 BU3  A 702 (-4.6A)
None
None
None
None
 1.48A 3ko0F-4dg8A:
undetectable
3ko0G-4dg8A:
0.0		 3ko0F-4dg8A:
9.40
3ko0G-4dg8A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 213
THR A 258
ALA A 216
ALA A 215
 BU3  A 703 ( 3.9A)
BU3  A 703 (-3.7A)
None
BU3  A 703 ( 3.8A)
 0.99A 3ns1C-4dg8A:
undetectable		 3ns1C-4dg8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 8 ILE A  89
LEU A  56
MET A  34
GLY A 227
 None
 1.05A 3selX-4dg8A:
undetectable		 3selX-4dg8A:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 6 ILE A  89
LEU A  56
MET A  34
GLY A 227
 None
 0.83A 3sj1X-4dg8A:
undetectable		 3sj1X-4dg8A:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		5 / 7 ASP A 214
GLY A 283
THR A 310
PHE A 315
LYS A 421
 AMP  A 701 ( 4.3A)
BU3  A 702 ( 3.1A)
AMP  A 701 (-3.8A)
None
AMP  A 701 ( 3.0A)
 0.92A 3vnsA-4dg8A:
45.8		 3vnsA-4dg8A:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  89
LEU A  56
MET A  34
GLY A 227
 None
 0.89A 4hbfA-4dg8A:
undetectable		 4hbfA-4dg8A:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  89
LEU A  56
MET A  34
GLY A 227
 None
 0.98A 4hc3A-4dg8A:
undetectable		 4hc3A-4dg8A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 406
ARG A 403
LEU A 410
ILE A 333
LEU A 286
 None
 1.50A 4k38A-4dg8A:
undetectable
4k38D-4dg8A:
undetectable		 4k38A-4dg8A:
19.97
4k38D-4dg8A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 448
THR A 463
ALA A 461
LEU A 459
 None
 0.99A 4pwjA-4dg8A:
undetectable		 4pwjA-4dg8A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  57
TRP A 221
LEU A  63
VAL A  51
 None
 0.96A 4udaA-4dg8A:
undetectable		 4udaA-4dg8A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		5 / 12 SER A  88
LEU A 246
ASP A  46
ARG A 145
GLU A  87
 None
 1.40A 4zjlD-4dg8A:
0.0		 4zjlD-4dg8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 206
ALA A 255
LEU A 261
HIS A 298
LEU A 301
 None
 1.20A 5dxgB-4dg8A:
undetectable		 5dxgB-4dg8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4dg8 PA1221
(Pseudomonas
aeruginosa) 		4 / 4 HIS A  24
GLY A 186
ARG A 189
THR A 313
 None
 0.92A 5nn4A-4dg8A:
0.3		 5nn4A-4dg8A:
21.22