SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dgf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4dgf SULFATE TRANSPORTER
SULFATE TRANSPORTER
FAMILY PROTEIN
(Wolinella
succinogenes) 		4 / 6 MET A 500
MET A 489
VAL A 522
LEU A 519
 None
 1.16A 1x8vA-4dgfA:
undetectable		 1x8vA-4dgfA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4dgf SULFATE TRANSPORTER
SULFATE TRANSPORTER
FAMILY PROTEIN
(Wolinella
succinogenes) 		4 / 8 ALA A 551
ALA A 555
ILE A 548
THR A 445
 None
None
CL  A 601 ( 4.5A)
None
 0.82A 3dtuC-4dgfA:
undetectable
3dtuD-4dgfA:
undetectable		 3dtuC-4dgfA:
12.61
3dtuD-4dgfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4dgf SULFATE TRANSPORTER
SULFATE TRANSPORTER
FAMILY PROTEIN
(Wolinella
succinogenes) 		3 / 3 GLU A 508
GLU A 511
TRP A 504
 None
 1.26A 3hrdA-4dgfA:
undetectable
3hrdE-4dgfA:
undetectable
3hrdF-4dgfA:
undetectable		 3hrdA-4dgfA:
17.18
3hrdE-4dgfA:
17.18
3hrdF-4dgfA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4dgf SULFATE TRANSPORTER
SULFATE TRANSPORTER
FAMILY PROTEIN
(Wolinella
succinogenes) 		5 / 12 ILE A 459
VAL A 522
LEU A 526
VAL A 492
ILE A 495
 FMT  A 602 (-4.7A)
None
None
None
None
 0.99A 5mueA-4dgfA:
3.3		 5mueA-4dgfA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4dgf SULFATE TRANSPORTER
SULFATE TRANSPORTER
FAMILY PROTEIN
(Wolinella
succinogenes) 		5 / 10 ALA A 502
LEU A 503
LEU A 487
VAL A 467
ILE A 459
 None
None
None
FMT  A 602 ( 4.1A)
FMT  A 602 (-4.7A)
 0.93A 5v02B-4dgfA:
undetectable
5v02R-4dgfA:
undetectable		 5v02B-4dgfA:
20.29
5v02R-4dgfA:
22.81