SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		6 / 8 HIS A  41
ASP A 181
SER A 182
GLN A 184
GLY A 208
GLY A 218
 None
 0.36A 1aq7A-4dgjA:
36.8		 1aq7A-4dgjA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		6 / 8 HIS A  41
ASP A 181
SER A 182
SER A 187
GLY A 208
GLY A 218
 None
 0.55A 1aq7A-4dgjA:
36.8		 1aq7A-4dgjA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 HIS A  41
ASP A 181
SER A 187
GLY A 208
GLY A 218
 None
 0.72A 1etrH-4dgjA:
36.3		 1etrH-4dgjA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 ASP A 181
SER A 182
GLY A 208
GLY A 218
 None
 0.26A 1f5lA-4dgjA:
36.6		 1f5lA-4dgjA:
34.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLY A 208
ASP A  92
HIS A  41
ALA A  39
 None
 0.99A 1gxsA-4dgjA:
undetectable
1gxsB-4dgjA:
undetectable		 1gxsA-4dgjA:
21.79
1gxsB-4dgjA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 THR A 140
ILE A  56
GLY A  17
GLY A  27
SER A  29
 None
 0.97A 1sg9B-4dgjA:
undetectable		 1sg9B-4dgjA:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		5 / 6 ASP A 181
SER A 182
SER A 187
GLY A 208
GLY A 218
 None
 0.57A 1tnlA-4dgjA:
36.8		 1tnlA-4dgjA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 ASP A 181
SER A 182
GLY A 208
GLY A 218
 None
 0.16A 2otvA-4dgjA:
37.0		 2otvA-4dgjA:
37.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 ILE A  93
ALA A  39
GLY A 188
VAL A  31
GLY A 203
 None
 1.06A 2qe6B-4dgjA:
undetectable		 2qe6B-4dgjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 ILE A 171
GLY A 203
LEU A 201
LEU A 113
 None
 0.81A 2vctA-4dgjA:
undetectable		 2vctA-4dgjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 ILE A 171
GLY A 203
LEU A 201
LEU A 113
 None
 0.83A 2vctB-4dgjA:
undetectable		 2vctB-4dgjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 ILE A 171
GLY A 203
LEU A 201
LEU A 113
 None
 0.85A 2vctC-4dgjA:
undetectable		 2vctC-4dgjA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 ASP A 181
SER A 182
GLY A 208
GLY A 218
 None
 0.29A 2vinA-4dgjA:
37.0		 2vinA-4dgjA:
34.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		5 / 11 GLY A 130
GLY A 132
ILE A 180
SER A   5
ALA A 147
 None
 0.74A 3dcmX-4dgjA:
undetectable		 3dcmX-4dgjA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 174
ILE A 171
GLY A 203
ASN A 125
LEU A 152
 None
 1.05A 3eeyD-4dgjA:
undetectable		 3eeyD-4dgjA:
25.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		6 / 11 HIS A  41
ASP A 181
SER A 182
GLN A 184
GLY A 208
GLY A 218
 None
 0.30A 3gy3A-4dgjA:
36.7		 3gy3A-4dgjA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		6 / 11 HIS A  41
ASP A 181
SER A 182
SER A 187
GLY A 208
GLY A 218
 None
 0.63A 3gy3A-4dgjA:
36.7		 3gy3A-4dgjA:
37.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 ILE A 111
GLN A 194
ALA A 202
LEU A 201
 None
 0.88A 3ozwA-4dgjA:
undetectable		 3ozwA-4dgjA:
18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 SER A 182
SER A 187
GLY A 208
GLY A 218
 None
 0.67A 3rxfA-4dgjA:
14.9		 3rxfA-4dgjA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 ASP A 181
SER A 182
SER A 187
GLY A 218
 None
 0.55A 3rxhA-4dgjA:
37.2		 3rxhA-4dgjA:
37.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 ILE A 108
VAL A  16
LEU A  18
ILE A  56
 None
 0.85A 4asdA-4dgjA:
undetectable		 4asdA-4dgjA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 HIS A  41
GLN A 184
GLY A 185
SER A 187
 None
 1.04A 4fu8A-4dgjA:
36.7		 4fu8A-4dgjA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 ASP A  92
TRP A  53
SER A 187
 None
 0.94A 4lrhB-4dgjA:
undetectable		 4lrhB-4dgjA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 ASP A  92
TRP A  53
SER A 187
 None
 1.05A 4lrhF-4dgjA:
undetectable		 4lrhF-4dgjA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 188
ALA A  28
ALA A 221
ALA A  39
ALA A  40
 None
 1.05A 5zw4A-4dgjA:
undetectable		 5zw4A-4dgjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLN A 145
VAL A   2
ALA A 212
TYR A 175
 None
 0.94A 6cduH-4dgjA:
undetectable
6cduI-4dgjA:
undetectable		 6cduH-4dgjA:
21.30
6cduI-4dgjA:
21.30