SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP21
PRE-MRNA-SPLICING
FACTOR PRP11
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP C 234
LYS C 238
ARG B 225
 None
 1.12A 1ra8A-4dgwC:
undetectable		 1ra8A-4dgwC:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP21
(Saccharomyces
cerevisiae) 		4 / 7 THR B 136
PHE B 135
THR B 134
LYS B  97
 None
 1.23A 2kotA-4dgwB:
undetectable		 2kotA-4dgwB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP9
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 352
ASP A 355
GLU A 353
ARG A 341
 None
 1.45A 2ouzA-4dgwA:
undetectable		 2ouzA-4dgwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP9
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 327
PHE A 245
TYR A 324
ALA A 253
ALA A 255
 None
 1.25A 2x2nA-4dgwA:
undetectable		 2x2nA-4dgwA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP9
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 327
PHE A 245
TYR A 324
ALA A 253
ALA A 255
 None
 1.20A 2x2nD-4dgwA:
undetectable		 2x2nD-4dgwA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP9
(Saccharomyces
cerevisiae) 		5 / 8 TYR A 327
PHE A 245
TYR A 324
ALA A 253
ALA A 255
 None
 1.36A 3l4dA-4dgwA:
undetectable		 3l4dA-4dgwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP9
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 327
PHE A 245
TYR A 324
ALA A 253
ALA A 255
 None
 1.39A 3l4dC-4dgwA:
undetectable		 3l4dC-4dgwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP9
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 353
PHE A 338
GLN A 175
 None
 0.82A 3r55A-4dgwA:
undetectable		 3r55A-4dgwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP21
PRE-MRNA-SPLICING
FACTOR PRP11
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG B 225
LYS C 239
LYS C 238
 None
 1.15A 4k50A-4dgwB:
undetectable		 4k50A-4dgwB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP21
PRE-MRNA-SPLICING
FACTOR PRP11
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG B 225
LYS C 239
LYS C 238
 None
 1.14A 4k50E-4dgwB:
undetectable		 4k50E-4dgwB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP21
PRE-MRNA-SPLICING
FACTOR PRP11
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG B 225
LYS C 239
LYS C 238
 None
 1.16A 4k50I-4dgwB:
undetectable		 4k50I-4dgwB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP21
PRE-MRNA-SPLICING
FACTOR PRP9
(Saccharomyces
cerevisiae) 		3 / 3 THR B 168
HIS A  77
LEU A 250
 None
 0.77A 5axdA-4dgwB:
undetectable		 5axdA-4dgwB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP9
PRE-MRNA-SPLICING
FACTOR PRP21
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 116
TYR B 103
PHE B 124
ILE B  96
GLU B 119
 None
 1.35A 5w8aA-4dgwA:
undetectable		 5w8aA-4dgwA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4dgw PRE-MRNA-SPLICING
FACTOR PRP11
(Saccharomyces
cerevisiae) 		4 / 7 ILE C 155
GLN C 156
VAL C 157
ILE C 209
 None
 0.94A 6cduF-4dgwC:
undetectable
6cduG-4dgwC:
undetectable		 6cduF-4dgwC:
11.07
6cduG-4dgwC:
11.07