SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dh2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A  82
TYR A  80
PHE A  91
PHE A  78
 None
 1.15A 1e71M-4dh2A:
undetectable		 1e71M-4dh2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A  82
TYR A  80
PHE A  91
PHE A  78
 None
 1.18A 1e72M-4dh2A:
undetectable		 1e72M-4dh2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4dh2 DOCKERIN TYPE 1
(Ruminiclostridiu
m
thermocellum) 		4 / 4 VAL B  43
ALA B  37
LEU B  23
PHE B  35
 None
 1.21A 1q97B-4dh2B:
undetectable		 1q97B-4dh2B:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 12 HIS A  44
ASP A 145
LEU A 146
ILE A 149
SER A 139
 None
 1.39A 1xmuA-4dh2A:
undetectable		 1xmuA-4dh2A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 12 HIS A  44
ASP A 145
LEU A 146
ILE A 149
SER A 139
 None
 1.35A 1xmuB-4dh2A:
undetectable		 1xmuB-4dh2A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 12 HIS A  44
ASP A 145
LEU A 146
ILE A 149
SER A 139
 None
 1.37A 1xomA-4dh2A:
undetectable		 1xomA-4dh2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 12 HIS A  44
ASP A 145
LEU A 146
ILE A 149
SER A 139
 None
 1.37A 1xoqA-4dh2A:
undetectable		 1xoqA-4dh2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 12 HIS A  44
ASP A 145
LEU A 146
ILE A 149
SER A 139
 None
 1.34A 1xoqB-4dh2A:
undetectable		 1xoqB-4dh2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 12 HIS A  44
ASP A 145
LEU A 146
ILE A 149
SER A 139
 None
 1.36A 3g4lD-4dh2A:
undetectable		 3g4lD-4dh2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 113
ILE A  89
LEU A  53
PHE A  78
SER A  69
 None
 1.22A 3ko0K-4dh2A:
undetectable
3ko0L-4dh2A:
undetectable
3ko0S-4dh2A:
undetectable
3ko0T-4dh2A:
undetectable		 3ko0K-4dh2A:
20.47
3ko0L-4dh2A:
20.47
3ko0S-4dh2A:
20.47
3ko0T-4dh2A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4dh2 DOCKERIN TYPE 1
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP B  20
PHE B  71
VAL B  46
LEU B  64
 CA  B 101 (-2.1A)
None
None
None
 1.19A 4f5zA-4dh2B:
undetectable		 4f5zA-4dh2B:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
DOCKERIN TYPE 1
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP B   9
ASP B  20
ASN A 140
 CA  B 101 (-3.3A)
CA  B 101 (-2.1A)
None
 0.74A 4q5mA-4dh2B:
undetectable		 4q5mA-4dh2B:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLY A 102
PHE A  93
ILE A  71
PHE A  49
 None
 1.09A 4qogA-4dh2A:
undetectable
4qogB-4dh2A:
undetectable		 4qogA-4dh2A:
24.47
4qogB-4dh2A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		6 / 12 LEU A  36
LEU A  53
GLU A 161
ILE A  60
VAL A  62
VAL A  65
 None
 1.37A 4y0sA-4dh2A:
undetectable		 4y0sA-4dh2A:
24.19