SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		5 / 10 THR A 148
PHE A  30
ASN A  35
GLY A  37
ALA A  41
 CL  A 303 ( 3.1A)
None
None
CL  A 303 ( 3.7A)
None
 1.36A 2x2iB-4dheA:
undetectable		 2x2iB-4dheA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		5 / 12 THR A 148
PHE A  30
ASN A  35
GLY A  37
ALA A  41
 CL  A 303 ( 3.1A)
None
None
CL  A 303 ( 3.7A)
None
 1.27A 2x2iC-4dheA:
undetectable		 2x2iC-4dheA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		4 / 5 TYR A 172
GLU A 127
ASP A 129
ASP A 120
 None
 1.44A 2yqzA-4dheA:
undetectable		 2yqzA-4dheA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		4 / 5 TYR A 172
GLU A 127
ASP A 129
ASP A 120
 None
 1.44A 2yqzB-4dheA:
undetectable		 2yqzB-4dheA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		5 / 12 MET A 118
ILE A 116
LEU A 146
ILE A  42
LEU A   5
 None
 1.14A 3a50D-4dheA:
undetectable		 3a50D-4dheA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		4 / 6 GLY A  84
GLY A  32
MET A 118
ASN A  35
 None
 1.00A 3e9rA-4dheA:
4.6		 3e9rA-4dheA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		4 / 6 GLY A  84
GLY A  32
MET A 118
ASN A  35
 None
 1.01A 3e9rC-4dheA:
3.8		 3e9rC-4dheA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		4 / 8 GLN A 184
GLY A 193
GLY A  37
ASN A  43
 None
None
CL  A 303 ( 3.7A)
None
 0.98A 3v3nB-4dheA:
undetectable		 3v3nB-4dheA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		4 / 5 TYR A  66
GLU A  27
LEU A  20
GLN A 111
 None
 1.40A 4qztB-4dheA:
undetectable		 4qztB-4dheA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		5 / 12 CYH A  46
LEU A  51
ASN A  65
VAL A  69
ALA A   8
 None
 1.12A 4x1kD-4dheA:
3.5		 4x1kD-4dheA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		3 / 3 THR A  40
ALA A 188
LYS A 190
 None
CL  A 302 (-3.5A)
None
 0.61A 6fgcA-4dheA:
2.3		 6fgcA-4dheA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4dhe PROBABLE GTP-BINDING
PROTEIN ENGB
(Burkholderia
thailandensis) 		3 / 3 THR A  40
ALA A 188
LYS A 190
 None
CL  A 302 (-3.5A)
None
 0.60A 6fgdA-4dheA:
2.1		 6fgdA-4dheA:
20.39