SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 12 ALA A 263
TYR A 240
SER A 143
GLU A 242
ASP A 289
 None
 1.08A 1dy4A-4dhgA:
undetectable		 1dy4A-4dhgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		6 / 12 ILE A 288
ALA A 303
ALA A 300
LEU A 313
ALA A 337
HIS A 291
 None
 1.29A 1fbyA-4dhgA:
undetectable		 1fbyA-4dhgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		6 / 12 ILE A 288
ALA A 303
ALA A 300
LEU A 313
ALA A 337
HIS A 291
 None
 1.30A 1fbyB-4dhgA:
undetectable		 1fbyB-4dhgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 5 LEU A 313
PRO A 336
ALA A 337
ILE A 338
 None
 1.02A 2aofB-4dhgA:
undetectable		 2aofB-4dhgA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 12 ASN A 318
ASP A 400
GLY A 395
ASP A  15
PRO A  27
 PO4  A 501 ( 4.8A)
None
None
None
None
 1.15A 2f8lA-4dhgA:
undetectable		 2f8lA-4dhgA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 8 HIS A 290
SER A 324
ILE A 323
HIS A 291
 None
 0.95A 2xadA-4dhgA:
undetectable		 2xadA-4dhgA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 8 HIS A 290
SER A 324
ILE A 323
HIS A 291
 None
 0.95A 2xadB-4dhgA:
undetectable		 2xadB-4dhgA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 8 HIS A 290
SER A 324
ILE A 323
HIS A 291
 None
 0.94A 2xadC-4dhgA:
undetectable		 2xadC-4dhgA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 8 HIS A 290
SER A 324
ILE A 323
HIS A 291
 None
 0.96A 2xadD-4dhgA:
undetectable		 2xadD-4dhgA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 12 LEU A 375
ALA A 110
ALA A 327
CYH A 306
LEU A 286
 None
 1.04A 3b0wA-4dhgA:
undetectable		 3b0wA-4dhgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 5 VAL A 355
VAL A 354
GLN A 352
ARG A  14
 None
 1.39A 3bjwH-4dhgA:
undetectable		 3bjwH-4dhgA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 9 LEU A  65
VAL A   6
LEU A  73
ALA A 115
GLU A 113
 None
 1.00A 3mdvA-4dhgA:
undetectable		 3mdvA-4dhgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 12 LEU A  65
VAL A   6
LEU A  73
ALA A 115
GLU A 113
 None
 0.99A 3mdvB-4dhgA:
undetectable		 3mdvB-4dhgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 11 LEU A 325
VAL A 367
ALA A 366
PHE A 183
THR A 344
 None
 1.16A 3n23C-4dhgA:
undetectable		 3n23C-4dhgA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 5 LEU A 325
GLN A 349
THR A 346
HIS A 290
 None
 1.45A 3n58C-4dhgA:
undetectable		 3n58C-4dhgA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 10 ALA A  81
LEU A  65
ALA A 111
VAL A  36
VAL A  70
 None
 1.40A 3r9cA-4dhgA:
undetectable		 3r9cA-4dhgA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 11 ALA A 115
VAL A 128
GLY A 121
ALA A 123
LEU A 296
 None
 1.00A 3sm2B-4dhgA:
undetectable		 3sm2B-4dhgA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 8 GLU A  35
LEU A  45
VAL A 354
LEU A 384
 None
 0.90A 3uniB-4dhgA:
undetectable		 3uniB-4dhgA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		3 / 3 LYS A 122
ARG A 381
LEU A  45
 None
 0.99A 3v4tE-4dhgA:
undetectable		 3v4tE-4dhgA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 8 ARG A 397
LEU A  55
ARG A  59
HIS A 388
 None
 1.25A 3zmdA-4dhgA:
undetectable
3zmdB-4dhgA:
undetectable		 3zmdA-4dhgA:
18.81
3zmdB-4dhgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 12 PHE A 183
LEU A 176
LEU A 188
LEU A 146
LEU A 165
 None
 1.06A 4dm8B-4dhgA:
undetectable		 4dm8B-4dhgA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 7 ASP A 343
ASP A 243
GLU A 239
ASP A 217
 None
 1.17A 4fevB-4dhgA:
undetectable		 4fevB-4dhgA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 8 ASP A 343
ASP A 243
GLU A 239
ASP A 217
 None
 1.13A 4gkhD-4dhgA:
undetectable		 4gkhD-4dhgA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		3 / 3 GLY A 372
PRO A 373
ALA A 124
 None
 0.56A 4qn9B-4dhgA:
undetectable		 4qn9B-4dhgA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 12 ALA A 332
THR A  48
SER A 299
LEU A 296
LEU A 375
 None
 1.37A 4qztC-4dhgA:
undetectable		 4qztC-4dhgA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		3 / 3 ALA A 366
TYR A 142
PRO A 370
 None
 0.67A 4zdyA-4dhgA:
undetectable		 4zdyA-4dhgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 11 LEU A 296
ASP A 118
LEU A  45
GLY A  44
ALA A 326
 None
 1.37A 5fctA-4dhgA:
undetectable		 5fctA-4dhgA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		3 / 3 TRP A 222
GLU A 198
ASP A 217
 None
 0.55A 5gqbA-4dhgA:
5.5		 5gqbA-4dhgA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 12 ILE A  88
VAL A  84
ALA A  62
ALA A  61
VAL A 108
 None
 1.04A 5igjA-4dhgA:
undetectable		 5igjA-4dhgA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 12 ILE A  88
VAL A  84
ALA A  62
ALA A  61
VAL A 108
 None
 1.02A 5igtA-4dhgA:
undetectable		 5igtA-4dhgA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		6 / 12 LEU A 296
ASP A 118
LEU A  45
GLY A  44
ILE A 323
ALA A 326
 None
 1.21A 5j7wD-4dhgA:
undetectable		 5j7wD-4dhgA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 9 ILE A 178
ALA A 144
ILE A 186
ILE A 170
LEU A 205
 None
 1.13A 5mvmA-4dhgA:
undetectable
5mvmE-4dhgA:
undetectable		 5mvmA-4dhgA:
13.26
5mvmE-4dhgA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		3 / 3 GLU A 239
ARG A 215
TYR A 240
 None
 0.56A 5trqB-4dhgA:
undetectable		 5trqB-4dhgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 5 ASN A  20
ASP A 401
ASP A  51
ASN A 318
 PO4  A 501 (-3.6A)
None
None
PO4  A 501 ( 4.8A)
 1.22A 5vooA-4dhgA:
3.3		 5vooA-4dhgA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 5 ASN A  20
ASP A 401
ASP A  51
ASN A 318
 PO4  A 501 (-3.6A)
None
None
PO4  A 501 ( 4.8A)
 1.30A 5vooC-4dhgA:
9.3		 5vooC-4dhgA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 5 ASN A  20
ASP A 401
ASP A  51
ASN A 318
 PO4  A 501 (-3.6A)
None
None
PO4  A 501 ( 4.8A)
 1.24A 5vooE-4dhgA:
5.4		 5vooE-4dhgA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 7 HIS A  25
ASP A 217
GLY A 190
ASN A  20
 PO4  A 501 (-4.0A)
None
None
PO4  A 501 (-3.6A)
 1.11A 5x7pA-4dhgA:
undetectable		 5x7pA-4dhgA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		4 / 5 HIS A  25
ASP A 217
GLY A 190
ASN A  20
 PO4  A 501 (-4.0A)
None
None
PO4  A 501 (-3.6A)
 1.10A 5x7pB-4dhgA:
undetectable		 5x7pB-4dhgA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Thermobispora
bispora) 		5 / 11 LEU A 296
ASP A 118
LEU A  45
GLY A  44
ALA A 326
 None
 1.29A 6r2eF-4dhgA:
undetectable		 6r2eF-4dhgA:
25.16