SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dhi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 4 ARG B  80
LEU B 160
ASN B 161
VAL B  95
None
1.28A 1lqtA-4dhiB:
undetectable
1lqtA-4dhiB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 4 ARG B  80
LEU B 160
ASN B 161
VAL B  95
None
1.30A 1lqtB-4dhiB:
undetectable
1lqtB-4dhiB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 4 ARG B  80
LEU B 160
ASN B 161
VAL B  95
None
1.29A 1lquA-4dhiB:
undetectable
1lquA-4dhiB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 4 ARG B  80
LEU B 160
ASN B 161
VAL B  95
None
1.32A 1lquB-4dhiB:
undetectable
1lquB-4dhiB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 12 ILE B 248
LEU B 261
VAL B 229
ILE B  93
ILE B  82
None
1.01A 1oipA-4dhiB:
undetectable
1oipA-4dhiB:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 ALA B  64
PHE B  65
ALA B  69
LEU B  53
None
0.69A 2bxmA-4dhiB:
2.9
2bxmA-4dhiB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 7 ALA B 217
TYR B  90
ASP B 214
TYR B 201
None
1.14A 2pncA-4dhiB:
undetectable
2pncA-4dhiB:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 TYR B 157
ARG B  80
ARG B  83
GLN B  38
None
1.42A 2vxaA-4dhiB:
undetectable
2vxaC-4dhiB:
undetectable
2vxaE-4dhiB:
undetectable
2vxaA-4dhiB:
13.07
2vxaC-4dhiB:
13.07
2vxaE-4dhiB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 TYR B 157
ARG B  80
ARG B  83
GLN B  38
None
1.39A 2vxaA-4dhiB:
undetectable
2vxaB-4dhiB:
undetectable
2vxaK-4dhiB:
undetectable
2vxaA-4dhiB:
13.07
2vxaB-4dhiB:
13.07
2vxaK-4dhiB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 TYR B 157
ARG B  80
ARG B  83
GLN B  38
None
1.39A 2vxaB-4dhiB:
undetectable
2vxaC-4dhiB:
undetectable
2vxaG-4dhiB:
undetectable
2vxaB-4dhiB:
13.07
2vxaC-4dhiB:
13.07
2vxaG-4dhiB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 TYR B 157
ARG B  80
ARG B  83
GLN B  38
None
1.38A 2vxaD-4dhiB:
undetectable
2vxaF-4dhiB:
undetectable
2vxaI-4dhiB:
undetectable
2vxaD-4dhiB:
13.07
2vxaF-4dhiB:
13.07
2vxaI-4dhiB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 TYR B 157
ARG B  80
ARG B  83
GLN B  38
None
1.39A 2vxaD-4dhiB:
undetectable
2vxaE-4dhiB:
undetectable
2vxaL-4dhiB:
undetectable
2vxaD-4dhiB:
13.07
2vxaE-4dhiB:
13.07
2vxaL-4dhiB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 ARG B  83
GLN B  38
TYR B 157
ARG B  80
None
1.40A 2vxaF-4dhiB:
undetectable
2vxaG-4dhiB:
undetectable
2vxaI-4dhiB:
undetectable
2vxaF-4dhiB:
13.07
2vxaG-4dhiB:
13.07
2vxaI-4dhiB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 ARG B  83
GLN B  38
TYR B 157
ARG B  80
None
1.42A 2vxaB-4dhiB:
undetectable
2vxaG-4dhiB:
undetectable
2vxaH-4dhiB:
undetectable
2vxaB-4dhiB:
13.07
2vxaG-4dhiB:
13.07
2vxaH-4dhiB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 TYR B 157
ARG B  80
ARG B  83
GLN B  38
None
1.41A 2vxaH-4dhiB:
undetectable
2vxaI-4dhiB:
undetectable
2vxaJ-4dhiB:
undetectable
2vxaH-4dhiB:
13.07
2vxaI-4dhiB:
13.07
2vxaJ-4dhiB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 ARG B  83
GLN B  38
TYR B 157
ARG B  80
None
1.40A 2vxaD-4dhiB:
undetectable
2vxaJ-4dhiB:
undetectable
2vxaL-4dhiB:
undetectable
2vxaD-4dhiB:
13.07
2vxaJ-4dhiB:
13.07
2vxaL-4dhiB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 ARG B  83
GLN B  38
TYR B 157
ARG B  80
None
1.41A 2vxaH-4dhiB:
undetectable
2vxaJ-4dhiB:
undetectable
2vxaK-4dhiB:
undetectable
2vxaH-4dhiB:
13.07
2vxaJ-4dhiB:
13.07
2vxaK-4dhiB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 ARG B  83
GLN B  38
TYR B 157
ARG B  80
None
1.40A 2vxaA-4dhiB:
undetectable
2vxaK-4dhiB:
undetectable
2vxaL-4dhiB:
undetectable
2vxaA-4dhiB:
13.07
2vxaK-4dhiB:
13.07
2vxaL-4dhiB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 11 ILE B 159
ALA B 166
PHE B 139
PHE B 142
VAL B 156
None
1.17A 2w3aA-4dhiB:
undetectable
2w3aA-4dhiB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 ILE B 100
PHE B 111
ARG B 228
GLY B 226
None
0.95A 3b9lA-4dhiB:
2.3
3b9lA-4dhiB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 12 GLY B 266
ILE B  79
LEU B  53
MET B 234
LEU B 261
None
1.27A 3cs8A-4dhiB:
undetectable
3cs8A-4dhiB:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 11 ARG B  80
PRO B 240
ILE B 271
ILE B 259
PRO B 257
None
1.44A 3ganA-4dhiB:
undetectable
3ganA-4dhiB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 12 GLU B 258
GLY B 226
GLY B  96
PHE B 111
ILE B 259
None
1.04A 3k13A-4dhiB:
undetectable
3k13A-4dhiB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 8 LEU B 216
TYR B 188
PHE B 191
TYR B 246
None
1.29A 3po7A-4dhiB:
undetectable
3po7A-4dhiB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 10 PHE B 172
PHE B 139
ALA B 225
THR B 227
ILE B 100
None
1.45A 3t3qA-4dhiB:
undetectable
3t3qA-4dhiB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 10 PHE B 172
PHE B 139
ALA B 225
THR B 227
ILE B 100
None
1.41A 3t3qB-4dhiB:
undetectable
3t3qB-4dhiB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 10 PHE B 172
PHE B 139
ALA B 225
THR B 227
ILE B 100
None
1.43A 3t3qC-4dhiB:
undetectable
3t3qC-4dhiB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 10 PHE B 172
PHE B 139
ALA B 225
THR B 227
ILE B 100
None
1.45A 3t3qD-4dhiB:
undetectable
3t3qD-4dhiB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 7 PHE B  65
ILE B 271
LEU B  72
PHE B  50
None
1.10A 4uymA-4dhiB:
1.4
4uymA-4dhiB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 10 VAL B  95
ILE B  98
LEU B 143
PHE B 139
ILE B 248
None
1.24A 5hw8C-4dhiB:
undetectable
5hw8H-4dhiB:
undetectable
5hw8C-4dhiB:
20.88
5hw8H-4dhiB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 6 ILE B  93
ILE B 146
LEU B 143
PHE B 111
None
1.07A 5vkqA-4dhiB:
2.3
5vkqB-4dhiB:
2.3
5vkqA-4dhiB:
10.32
5vkqB-4dhiB:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 6 ILE B  93
ILE B 146
LEU B 143
PHE B 111
None
1.05A 5vkqA-4dhiB:
2.3
5vkqD-4dhiB:
2.3
5vkqA-4dhiB:
10.32
5vkqD-4dhiB:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 12 GLU B 258
GLY B 226
GLY B  96
PHE B 111
ILE B 259
None
1.11A 5vooA-4dhiB:
undetectable
5vooA-4dhiB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 12 GLU B 258
GLY B 226
GLY B  96
PHE B 111
ILE B 259
None
1.16A 5vooB-4dhiB:
undetectable
5vooB-4dhiB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 12 GLU B 258
GLY B 226
GLY B  96
PHE B 111
ILE B 259
None
1.09A 5vooC-4dhiB:
undetectable
5vooC-4dhiB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 10 GLY B  84
GLU B  99
VAL B 156
GLU B 153
TYR B 157
None
1.27A 6cgdA-4dhiB:
4.1
6cgdA-4dhiB:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 12 THR B 227
SER B 114
SER B 115
PHE B 173
PHE B 172
None
1.38A 6h7jA-4dhiB:
undetectable
6h7jA-4dhiB:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
5 / 12 THR B 227
SER B 114
SER B 115
PHE B 173
PHE B 172
None
1.37A 6h7jB-4dhiB:
undetectable
6h7jB-4dhiB:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans)
4 / 6 TYR B 272
ILE B 271
ALA B  92
ARG B  80
None
1.06A 6hu9m-4dhiB:
undetectable
6hu9q-4dhiB:
undetectable
6hu9m-4dhiB:
19.48
6hu9q-4dhiB:
20.51