SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dhz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 4 ARG A  80
LEU A 160
ASN A 161
VAL A  95
 None
 1.17A 1lqtA-4dhzA:
undetectable		 1lqtA-4dhzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 PHE A 173
PHE A 139
SER A 115
TRP A 118
 None
 1.20A 1lqtA-4dhzA:
undetectable		 1lqtA-4dhzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 4 ARG A  80
LEU A 160
ASN A 161
VAL A  95
 None
 1.20A 1lqtB-4dhzA:
undetectable		 1lqtB-4dhzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 4 ARG A  80
LEU A 160
ASN A 161
VAL A  95
 None
 1.18A 1lquA-4dhzA:
undetectable		 1lquA-4dhzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 PHE A 173
PHE A 139
SER A 115
TRP A 118
 None
 1.20A 1lquA-4dhzA:
undetectable		 1lquA-4dhzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 4 ARG A  80
LEU A 160
ASN A 161
VAL A  95
 None
 1.21A 1lquB-4dhzA:
undetectable		 1lquB-4dhzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 11 ILE A 159
ALA A 166
PHE A 139
PHE A 142
VAL A 156
 None
 1.17A 2w3aA-4dhzA:
undetectable		 2w3aA-4dhzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 12 ILE A 169
LEU A  94
ILE A 159
PHE A 142
VAL A 150
 None
 1.04A 2ygqA-4dhzA:
undetectable		 2ygqA-4dhzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 11 VAL A 270
TYR A  81
ILE A  98
TYR A 272
TYR A 157
 None
 1.45A 3q5rA-4dhzA:
undetectable		 3q5rA-4dhzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 5 ARG A 264
ASP A 269
GLU A 232
VAL A 229
 None
 1.35A 4nkvB-4dhzA:
undetectable		 4nkvB-4dhzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 11 ALA A  64
GLY A 242
GLY A 243
ALA A 239
ASP A 235
 None
 1.04A 4qvlK-4dhzA:
undetectable
4qvlL-4dhzA:
undetectable		 4qvlK-4dhzA:
22.74
4qvlL-4dhzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 9 ALA A  64
GLY A 242
GLY A 243
ALA A 239
ASP A 235
 None
 1.04A 4qvmK-4dhzA:
undetectable
4qvmL-4dhzA:
undetectable		 4qvmK-4dhzA:
22.74
4qvmL-4dhzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 10 ALA A  64
GLY A 242
GLY A 243
ALA A 239
ASP A 235
 None
 1.03A 4qvmY-4dhzA:
undetectable
4qvmZ-4dhzA:
undetectable		 4qvmY-4dhzA:
22.74
4qvmZ-4dhzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 10 ALA A  64
GLY A 242
GLY A 243
ALA A 239
ASP A 235
 None
 1.01A 4qvpK-4dhzA:
undetectable
4qvpL-4dhzA:
undetectable		 4qvpK-4dhzA:
22.74
4qvpL-4dhzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 10 ALA A  64
GLY A 242
GLY A 243
ALA A 239
ASP A 235
 None
 1.01A 4qvpY-4dhzA:
undetectable
4qvpZ-4dhzA:
undetectable		 4qvpY-4dhzA:
22.74
4qvpZ-4dhzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 11 ALA A  64
GLY A 242
GLY A 243
ALA A 239
ASP A 235
 None
 1.01A 4qw1K-4dhzA:
undetectable
4qw1L-4dhzA:
undetectable		 4qw1K-4dhzA:
22.74
4qw1L-4dhzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 10 ALA A  64
GLY A 242
GLY A 243
ALA A 239
ASP A 235
 None
 1.01A 4qw1Y-4dhzA:
undetectable
4qw1Z-4dhzA:
undetectable		 4qw1Y-4dhzA:
22.74
4qw1Z-4dhzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 10 ALA A  64
GLY A 242
GLY A 243
ALA A 239
ASP A 235
 None
 1.05A 4qw3K-4dhzA:
undetectable
4qw3L-4dhzA:
undetectable		 4qw3K-4dhzA:
22.74
4qw3L-4dhzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 10 ALA A  64
GLY A 242
GLY A 243
ALA A 239
ASP A 235
 None
 1.06A 4qw3Y-4dhzA:
undetectable
4qw3Z-4dhzA:
undetectable		 4qw3Y-4dhzA:
22.74
4qw3Z-4dhzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 8 LEU A 221
ALA A 224
ILE A 176
LEU A 181
ALA A 213
 None
 1.01A 4wboB-4dhzA:
undetectable		 4wboB-4dhzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_B_FOLB201_0
(FOLATE ECF
TRANSPORTER)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 12 ALA A  92
TYR A  90
PHE A 173
THR A 177
ARG A 107
 None
 1.46A 4z7fB-4dhzA:
0.1		 4z7fB-4dhzA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 9 ALA A  64
GLY A 242
GLY A 243
ALA A 239
ASP A 235
 None
 1.04A 5d0xK-4dhzA:
undetectable
5d0xL-4dhzA:
undetectable		 5d0xK-4dhzA:
22.74
5d0xL-4dhzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 9 ALA A  64
GLY A 242
GLY A 243
ALA A 239
ASP A 235
 None
 1.03A 5d0xY-4dhzA:
undetectable
5d0xZ-4dhzA:
undetectable		 5d0xY-4dhzA:
22.74
5d0xZ-4dhzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		6 / 12 ILE A 176
ILE A  82
ILE A 169
LEU A 160
VAL A  44
PHE A 111
 None
 1.42A 5mueA-4dhzA:
undetectable		 5mueA-4dhzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 12 ASP A 104
LEU A 160
VAL A  44
PHE A 139
ALA A 225
 None
 1.13A 5uxdB-4dhzA:
3.2		 5uxdB-4dhzA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 6 TYR A 272
ILE A 271
ALA A  92
ARG A  80
 None
 0.95A 6hu9m-4dhzA:
undetectable
6hu9q-4dhzA:
undetectable		 6hu9m-4dhzA:
19.63
6hu9q-4dhzA:
19.42