SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4di3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4di3 TATT (TP0956)
(Treponema
pallidum) 		5 / 12 ASN A 278
VAL A 282
ASN A 204
LEU A 231
ALA A 267
 None
 1.10A 2iyfB-4di3A:
undetectable		 2iyfB-4di3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4di3 TATT (TP0956)
(Treponema
pallidum) 		4 / 8 ASN A  82
VAL A 164
SER A 285
THR A 245
 None
 0.89A 2yoeB-4di3A:
2.8
2yoeC-4di3A:
2.7		 2yoeB-4di3A:
19.40
2yoeC-4di3A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4di3 TATT (TP0956)
(Treponema
pallidum) 		4 / 6 PHE A 209
ALA A 224
GLY A 220
TYR A 210
 None
 1.14A 3dd1B-4di3A:
undetectable		 3dd1B-4di3A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4di3 TATT (TP0956)
(Treponema
pallidum) 		4 / 6 PHE A 129
LEU A 156
ALA A 182
LEU A 119
 None
 1.00A 3t3zA-4di3A:
undetectable		 3t3zA-4di3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4di3 TATT (TP0956)
(Treponema
pallidum) 		4 / 6 PHE A 129
LEU A 156
ALA A 182
LEU A 119
 None
 0.97A 3t3zD-4di3A:
undetectable		 3t3zD-4di3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4di3 TATT (TP0956)
(Treponema
pallidum) 		4 / 7 THR A 161
TRP A 158
ASN A  82
TYR A 157
 None
 1.48A 4a3uA-4di3A:
undetectable		 4a3uA-4di3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4di3 TATT (TP0956)
(Treponema
pallidum) 		4 / 7 THR A 161
TRP A 158
ASN A  82
TYR A 157
 None
 1.49A 4a3uB-4di3A:
undetectable		 4a3uB-4di3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4di3 TATT (TP0956)
(Treponema
pallidum) 		5 / 11 ASN A 278
VAL A 282
ASN A 204
LEU A 231
ALA A 267
 None
 1.12A 4m83A-4di3A:
undetectable		 4m83A-4di3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 4di3 TATT (TP0956)
(Treponema
pallidum) 		5 / 12 ALA A 115
SER A 120
GLU A 123
TYR A 197
PHE A 129
 None
 1.49A 5vlmH-4di3A:
3.2		 5vlmH-4di3A:
19.54