SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4di4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		3 / 3 ARG B 256
ARG B 254
ARG B 116
 None
 1.12A 1l7fA-4di4B:
undetectable		 1l7fA-4di4B:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		4 / 8 HIS B 245
ARG B 239
VAL B  43
TRP B  35
 None
 1.26A 1u1jA-4di4B:
undetectable		 1u1jA-4di4B:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		5 / 11 LEU B  87
LEU B  28
ILE B  93
VAL B 130
ILE B 131
 None
 1.19A 2uxoB-4di4B:
undetectable		 2uxoB-4di4B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		3 / 3 GLU B  34
GLN B 257
ARG B 256
 None
 0.96A 2w3bB-4di4B:
undetectable		 2w3bB-4di4B:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		5 / 11 VAL B 167
LEU B 168
GLY B 169
ILE B 179
PRO B 183
 None
 1.25A 3bjwB-4di4B:
undetectable		 3bjwB-4di4B:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		5 / 12 VAL B 167
LEU B 168
GLY B 169
ILE B 179
PRO B 183
 None
 1.24A 3bjwF-4di4B:
undetectable		 3bjwF-4di4B:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		5 / 10 ILE B  17
ALA B  77
SER B  85
SER B  91
ILE B  93
 None
 1.28A 3qgtB-4di4B:
undetectable		 3qgtB-4di4B:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		4 / 8 ASN B 272
ASP B 220
HIS B 283
GLU B 105
 None
 0.90A 3sg9B-4di4B:
undetectable		 3sg9B-4di4B:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		5 / 12 PHE B  79
ALA B  77
LEU B  53
SER B 233
GLY B  54
 None
 1.08A 4dm8B-4di4B:
undetectable		 4dm8B-4di4B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		5 / 12 PHE B  79
LEU B 231
ALA B  77
LEU B  53
GLY B  54
 None
 1.00A 4dm8B-4di4B:
undetectable		 4dm8B-4di4B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		4 / 8 LEU B 168
SER B  91
VAL B  78
GLY B 229
 None
 1.01A 4klrB-4di4B:
undetectable		 4klrB-4di4B:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		5 / 12 ILE B 232
LEU B  28
VAL B 255
ALA B 252
LEU B 249
 None
 1.50A 4m11D-4di4B:
undetectable		 4m11D-4di4B:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		4 / 7 LEU B 187
LEU B 190
SER B 195
THR B 157
 None
 0.94A 4pwjB-4di4B:
undetectable		 4pwjB-4di4B:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		4 / 6 LEU B 187
LEU B 190
SER B 195
THR B 157
 None
 1.04A 5bojA-4di4B:
undetectable		 5bojA-4di4B:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		5 / 12 VAL B 111
VAL B 227
MET B 310
GLY B  92
LEU B 119
 None
 1.07A 5iktA-4di4B:
undetectable		 5iktA-4di4B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		4 / 4 GLU B 288
PRO B 286
ILE B 289
LEU B 284
 None
 1.20A 5m45A-4di4B:
undetectable		 5m45A-4di4B:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		4 / 4 GLU B 288
PRO B 286
ILE B 289
LEU B 284
 None
 1.23A 5m45D-4di4B:
1.7		 5m45D-4di4B:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		4 / 4 GLU B 288
PRO B 286
ILE B 289
LEU B 284
 None
 1.19A 5m45G-4di4B:
undetectable		 5m45G-4di4B:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		4 / 4 GLU B 288
PRO B 286
ILE B 289
LEU B 284
 None
 1.25A 5m45J-4di4B:
0.0		 5m45J-4di4B:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		4 / 8 ILE B 289
TRP B 292
ARG B 293
ASP B 107
 None
 0.98A 5vlmF-4di4B:
undetectable		 5vlmF-4di4B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4di4 TATP(T) (TP0957)
(Treponema
pallidum) 		3 / 3 LEU B  82
ASN B 184
LEU B 160
 None
 0.76A 6exiD-4di4B:
undetectable		 6exiD-4di4B:
15.41