SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dim'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		3 / 3 ASP A 212
HIS A 210
HIS A 225
 None
 0.63A 1oe1A-4dimA:
undetectable		 1oe1A-4dimA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		3 / 3 ASP A 212
HIS A 210
HIS A 225
 None
 0.64A 1oe3A-4dimA:
undetectable		 1oe3A-4dimA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		5 / 12 GLY A  11
GLY A  13
ASP A  53
ILE A  54
CYH A  75
 None
 0.81A 1x1aA-4dimA:
3.7		 1x1aA-4dimA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		4 / 5 ALA A 299
TYR A 295
ALA A  73
GLN A 196
 None
 0.96A 1xl6A-4dimA:
undetectable
1xl6B-4dimA:
undetectable		 1xl6A-4dimA:
19.52
1xl6B-4dimA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		5 / 12 THR A  74
ALA A  73
LEU A   7
LEU A  69
MET A  52
 None
 1.10A 2jfaA-4dimA:
undetectable		 2jfaA-4dimA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		3 / 3 ASP A 212
HIS A 210
HIS A 225
 None
 0.60A 2xxgA-4dimA:
undetectable		 2xxgA-4dimA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		3 / 3 ASP A 212
HIS A 210
HIS A 225
 None
 0.63A 2xxgC-4dimA:
undetectable		 2xxgC-4dimA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		4 / 6 ASP A  78
LEU A 273
LEU A 282
HIS A 210
 None
 1.23A 3bj8C-4dimA:
undetectable
3bj8D-4dimA:
undetectable		 3bj8C-4dimA:
18.46
3bj8D-4dimA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		6 / 12 LEU A  10
THR A  74
ALA A  73
LEU A   7
LEU A  69
MET A  52
 None
 1.30A 3hm1A-4dimA:
undetectable		 3hm1A-4dimA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		5 / 12 ILE A 288
ALA A 323
GLN A 373
THR A 352
LEU A  17
 None
 0.94A 4qzuC-4dimA:
undetectable		 4qzuC-4dimA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		4 / 5 LEU A 229
VAL A 268
VAL A 259
TYR A 191
 None
 0.97A 4r7iA-4dimA:
undetectable		 4r7iA-4dimA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		5 / 12 THR A  74
ALA A  73
LEU A   7
LEU A  69
MET A  52
 None
 1.17A 4xi3D-4dimA:
undetectable		 4xi3D-4dimA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		4 / 7 VAL A 144
ALA A 160
GLY A 169
VAL A 146
 None
 0.91A 5fpdA-4dimA:
undetectable		 5fpdA-4dimA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		5 / 12 PRO A 283
GLU A 305
ALA A  72
ALA A  73
GLY A  95
 None
 0.94A 5igpA-4dimA:
undetectable		 5igpA-4dimA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		6 / 12 PRO A 283
GLU A 305
ALA A  72
ALA A  73
LEU A  84
GLY A  95
 None
 1.09A 5igtA-4dimA:
undetectable		 5igtA-4dimA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		5 / 12 ALA A 195
PRO A 209
GLY A 275
LEU A 250
LEU A 252
 None
 0.97A 5wwsA-4dimA:
3.6		 5wwsA-4dimA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		5 / 9 VAL A 259
VAL A 204
LEU A 273
GLY A 251
LEU A 252
 None
 1.33A 6czmA-4dimA:
undetectable
6czmB-4dimA:
undetectable		 6czmA-4dimA:
22.57
6czmB-4dimA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		5 / 10 VAL A 259
VAL A 204
LEU A 273
GLY A 251
LEU A 252
 None
 1.33A 6czmE-4dimA:
undetectable
6czmF-4dimA:
undetectable		 6czmE-4dimA:
22.57
6czmF-4dimA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Anaerococcus
prevotii) 		4 / 5 TYR A 226
GLY A 321
HIS A 225
ASP A 212
 None
 0.80A 6gh9A-4dimA:
undetectable		 6gh9A-4dimA:
11.50