SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4din'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
5 / 12 GLY B 199
VAL B 162
GLY B 223
ILE B 224
ILE B 163
None
0.91A 1c6zB-4dinB:
undetectable
1c6zB-4dinB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
5 / 12 GLY B 166
GLN B 164
VAL B 162
ALA B 202
LEU B 201
None
1.15A 1gs4A-4dinB:
undetectable
1gs4A-4dinB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
5 / 11 LEU B 269
VAL B 346
ILE B 292
GLU B 245
LEU B 254
None
1.35A 1mrqA-4dinB:
undetectable
1mrqA-4dinB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
4 / 6 ILE B 253
GLU B 362
ARG B 370
LEU B 257
None
1.03A 1mt1B-4dinB:
undetectable
1mt1C-4dinB:
undetectable
1mt1B-4dinB:
17.24
1mt1C-4dinB:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
6 / 12 LEU B 329
LEU B 328
ILE B 325
ILE B 253
ARG B 370
SER B 256
None
1.50A 1xdkF-4dinB:
undetectable
1xdkF-4dinB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
4 / 6 ALA B 150
TYR B 111
ILE B 224
ILE B 232
None
1.25A 2dcfA-4dinB:
undetectable
2dcfA-4dinB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
5 / 12 GLY B 199
VAL B 162
GLY B 223
ILE B 224
ILE B 163
None
1.02A 2f80A-4dinB:
undetectable
2f80A-4dinB:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
5 / 12 GLY B 199
VAL B 162
GLY B 223
ILE B 224
ILE B 163
None
0.89A 2pymA-4dinB:
undetectable
2pymA-4dinB:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
5 / 12 GLY B 199
VAL B 162
GLY B 223
ILE B 224
ILE B 163
None
0.88A 2pymB-4dinB:
undetectable
2pymB-4dinB:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
5 / 12 GLY B 199
VAL B 162
GLY B 223
ILE B 224
ILE B 163
None
0.88A 2pynA-4dinB:
undetectable
2pynA-4dinB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
5 / 12 GLY B 199
VAL B 162
GLY B 223
ILE B 224
ILE B 163
None
0.88A 2pynB-4dinB:
undetectable
2pynB-4dinB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
5 / 12 GLY B 199
VAL B 162
GLY B 223
ILE B 224
ILE B 163
None
0.90A 2q63B-4dinB:
undetectable
2q63B-4dinB:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
5 / 11 GLY B 199
VAL B 162
GLY B 223
ILE B 224
ILE B 163
None
0.88A 3ekxA-4dinB:
undetectable
3ekxA-4dinB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
3 / 3 GLN B 273
GLU B 295
LYS B 344
None
1.08A 3su9A-4dinB:
undetectable
3su9A-4dinB:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
5 / 11 GLY B 199
VAL B 162
GLY B 223
ILE B 224
ILE B 163
None
1.00A 4njvC-4dinB:
undetectable
4njvC-4dinB:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo
sapiens)
4 / 7 PHE B 148
ARG B 144
ILE B 147
TYR B 229
None
1.09A 5a06B-4dinB:
undetectable
5a06B-4dinB:
21.14