SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 12 GLY A 128
ASP A 125
THR A 393
VAL A 398
ILE A 133
 None
 1.00A 1fb7A-4dioA:
undetectable		 1fb7A-4dioA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 12 GLY A 140
ALA A 135
ALA A 132
THR A 393
THR A 143
 None
 0.93A 1gtnL-4dioA:
undetectable
1gtnV-4dioA:
undetectable		 1gtnL-4dioA:
11.11
1gtnV-4dioA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		4 / 6 GLU A  80
ALA A  86
LEU A  57
VAL A  88
 None
 1.19A 1sn5A-4dioA:
undetectable		 1sn5A-4dioA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 12 ALA A 132
THR A 393
THR A 143
GLY A 140
ALA A 135
 None
 0.91A 1utdL-4dioA:
undetectable
1utdM-4dioA:
undetectable		 1utdL-4dioA:
11.11
1utdM-4dioA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 11 ALA A 132
THR A 393
THR A 143
GLY A 140
ALA A 135
 None
 0.89A 1utdP-4dioA:
undetectable
1utdQ-4dioA:
undetectable		 1utdP-4dioA:
11.11
1utdQ-4dioA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 12 ILE A 291
ALA A 296
ASP A 226
VAL A 227
ARG A 228
 None
 0.84A 2qe6A-4dioA:
5.6		 2qe6A-4dioA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 12 ILE A 212
ALA A 215
ALA A 348
VAL A 347
VAL A 206
 None
 0.93A 2yvlC-4dioA:
6.4		 2yvlC-4dioA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 12 ALA A 352
GLY A  49
GLY A  73
LEU A 101
ALA A 360
 None
 0.95A 3douA-4dioA:
undetectable		 3douA-4dioA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 12 GLY A  85
LEU A 367
ILE A  76
VAL A  34
ILE A 121
 None
 1.05A 3frqB-4dioA:
undetectable		 3frqB-4dioA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 10 LEU A  57
ALA A  48
GLY A  71
ILE A  76
VAL A  64
 None
 1.08A 3nu6B-4dioA:
undetectable		 3nu6B-4dioA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 12 PRO A 185
ALA A 213
ALA A 240
GLY A 239
LEU A 238
 None
 1.03A 4oaeA-4dioA:
undetectable		 4oaeA-4dioA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 10 ALA A 211
ALA A 168
ALA A 172
VAL A 201
GLY A 205
 None
 1.04A 4qvyY-4dioA:
undetectable
4qvyZ-4dioA:
undetectable		 4qvyY-4dioA:
21.32
4qvyZ-4dioA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		4 / 5 LEU A 238
ALA A 204
THR A 288
ILE A 286
 None
 0.96A 4xe3B-4dioA:
undetectable		 4xe3B-4dioA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		3 / 3 VAL A  54
TYR A  81
ALA A  84
 None
 0.50A 4ybnA-4dioA:
undetectable		 4ybnA-4dioA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 9 ALA A  97
THR A  96
ALA A  94
GLY A 117
ALA A 118
 None
 1.08A 5d0xK-4dioA:
undetectable
5d0xL-4dioA:
undetectable		 5d0xK-4dioA:
20.95
5d0xL-4dioA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 9 ALA A  97
THR A  96
ALA A  94
GLY A 117
ALA A 118
 None
 1.08A 5d0xY-4dioA:
undetectable
5d0xZ-4dioA:
undetectable		 5d0xY-4dioA:
20.95
5d0xZ-4dioA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		4 / 5 ALA A 240
ALA A 224
ILE A 212
LEU A 209
 None
 0.55A 5jncD-4dioA:
undetectable		 5jncD-4dioA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 12 LEU A 317
VAL A 347
ALA A 355
ALA A 348
GLY A 349
 None
 1.15A 5tzoB-4dioA:
undetectable		 5tzoB-4dioA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 10 VAL A 206
GLY A 205
GLY A 203
LEU A 167
ALA A 165
 None
 1.05A 5vm8B-4dioA:
3.3		 5vm8B-4dioA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Sinorhizobium
meliloti) 		5 / 10 GLY A 322
GLY A 323
ASN A 324
ALA A 296
PRO A 295
 None
 1.01A 6e5zA-4dioA:
5.8		 6e5zA-4dioA:
20.25