SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
5 / 12 LEU A 445
ILE A 457
ASP A 381
GLY A 407
PHE A 459
None
1.22A 1zz1B-4dixA:
undetectable
1zz1C-4dixA:
undetectable
1zz1B-4dixA:
21.66
1zz1C-4dixA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
5 / 10 ILE A 457
ALA A 458
ALA A 444
GLN A 443
ILE A 411
None
1.08A 2aclC-4dixA:
undetectable
2aclC-4dixA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
5 / 10 ILE A 457
ALA A 458
ALA A 444
GLN A 443
ILE A 411
None
1.05A 3falA-4dixA:
undetectable
3falA-4dixA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
4 / 5 ILE A 420
HIS A 402
VAL A 388
HIS A 396
None
1.47A 3nneA-4dixA:
undetectable
3nneA-4dixA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
4 / 5 ILE A 420
HIS A 402
VAL A 388
HIS A 396
None
1.43A 3nneB-4dixA:
0.0
3nneB-4dixA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
4 / 5 VAL A 377
PHE A 384
PHE A 404
PHE A 459
None
1.00A 3owxB-4dixA:
undetectable
3owxB-4dixA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
4 / 7 TYR A 372
VAL A 373
LEU A 376
VAL A 406
None
1.14A 4e1gB-4dixA:
undetectable
4e1gB-4dixA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
4 / 8 ARG A 435
ASP A 339
PHE A 338
ASP A 488
None
1.14A 4xqgA-4dixA:
undetectable
4xqgA-4dixA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
4 / 8 ARG A 435
ASP A 339
PHE A 338
ASP A 488
None
1.14A 4xqgB-4dixA:
undetectable
4xqgB-4dixA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
3 / 3 ASN A 439
ASP A 284
GLY A 285
None
0.45A 5fctB-4dixA:
undetectable
5fctB-4dixA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
5 / 12 ALA A 328
THR A 490
GLY A 485
SER A 326
GLU A 487
None
1.36A 5hfjG-4dixA:
undetectable
5hfjG-4dixA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
3 / 3 CYH A 414
LYS A 415
HIS A 402
None
1.06A 5js5A-4dixA:
undetectable
5js5A-4dixA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana)
4 / 7 ASP A 339
PHE A 338
GLY A 485
GLY A 433
None
0.94A 5n9xA-4dixA:
undetectable
5n9xA-4dixA:
18.44