SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dj2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_A_SPMA924_1
(FMS1 PROTEIN)		 4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1
(Mus
musculus) 		5 / 11 TRP A 441
PHE A 360
LEU A 394
PHE A 427
LEU A 397
 None
 1.41A 1xpqA-4dj2A:
0.0		 1xpqA-4dj2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1
(Mus
musculus) 		5 / 12 LEU A 258
LEU A 318
PHE A 316
ILE A 301
ASP A 387
 None
 1.19A 3ko0K-4dj2A:
undetectable
3ko0L-4dj2A:
undetectable
3ko0M-4dj2A:
undetectable
3ko0N-4dj2A:
undetectable		 3ko0K-4dj2A:
15.71
3ko0L-4dj2A:
15.71
3ko0M-4dj2A:
15.71
3ko0N-4dj2A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1
(Mus
musculus) 		5 / 12 LEU A 318
PHE A 316
ILE A 301
LEU A 258
ASP A 387
 None
 1.22A 3ko0M-4dj2A:
undetectable
3ko0N-4dj2A:
undetectable
3ko0O-4dj2A:
undetectable
3ko0P-4dj2A:
undetectable		 3ko0M-4dj2A:
15.71
3ko0N-4dj2A:
15.71
3ko0O-4dj2A:
15.71
3ko0P-4dj2A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1
(Mus
musculus) 		4 / 5 HIS A 364
CYH A 368
ILE A 493
HIS A 409
 None
 1.41A 3qpkA-4dj2A:
undetectable		 3qpkA-4dj2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB601_0
(LACCASE-1)		 4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1
(Mus
musculus) 		4 / 4 HIS A 364
CYH A 368
ILE A 493
HIS A 409
 None
 1.42A 3qpkB-4dj2A:
undetectable		 3qpkB-4dj2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1
(Mus
musculus) 		3 / 3 PHE A 254
THR A 213
LEU A 242
 None
 0.78A 4qztA-4dj2A:
undetectable		 4qztA-4dj2A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1
(Mus
musculus) 		5 / 12 SER A 269
PHE A 226
PHE A 254
PHE A 266
VAL A 222
 None
 1.42A 6a94A-4dj2A:
undetectable		 6a94A-4dj2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1
(Mus
musculus) 		5 / 9 ALA A 252
ILE A 231
PHE A 220
GLY A 239
PHE A 249
 None
 1.22A 6awoA-4dj2A:
undetectable		 6awoA-4dj2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1
(Mus
musculus) 		5 / 9 ALA A 252
ILE A 231
PHE A 220
GLY A 239
PHE A 249
 None
 1.22A 6awqA-4dj2A:
undetectable		 6awqA-4dj2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1
(Mus
musculus) 		4 / 4 LEU A 384
ASP A 387
GLN A 261
VAL A 240
 None
 1.31A 6bzoF-4dj2A:
undetectable		 6bzoF-4dj2A:
20.88