SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dje'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 5 HIS D  44
GLU D  47
ALA D 322
SER D 320
 None
 1.32A 1errA-4djeD:
undetectable
1errB-4djeD:
undetectable		 1errA-4djeD:
19.83
1errB-4djeD:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 6 LEU D 300
GLY D 254
LYS D 101
TYR D  99
 None
 0.97A 1gtiC-4djeD:
undetectable		 1gtiC-4djeD:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 7 LEU D 300
GLY D 254
LYS D 101
TYR D  99
 None
 0.97A 1gtiD-4djeD:
undetectable		 1gtiD-4djeD:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 7 LEU D 300
GLY D 254
LYS D 101
TYR D  99
 None
 0.97A 1gtiE-4djeD:
undetectable		 1gtiE-4djeD:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 5 LEU D 300
GLY D 254
LYS D 101
TYR D  99
 None
 0.97A 1gtiF-4djeD:
undetectable		 1gtiF-4djeD:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 6 ILE D 281
GLY D 280
ALA D 263
HIS D 303
 None
 0.99A 1wmqA-4djeD:
undetectable		 1wmqA-4djeD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 6 ILE D 281
GLY D 280
ALA D 263
HIS D 303
 None
 0.97A 1wmqB-4djeD:
undetectable		 1wmqB-4djeD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 6 ILE D 281
GLY D 280
ALA D 263
HIS D 303
 None
 0.96A 1wpuA-4djeD:
undetectable		 1wpuA-4djeD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 6 ILE D 281
GLY D 280
ALA D 263
HIS D 303
 None
 0.97A 1wpuB-4djeD:
undetectable		 1wpuB-4djeD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 6 ILE D 281
GLY D 280
ALA D 263
HIS D 303
 None
 0.98A 1wrqA-4djeD:
undetectable		 1wrqA-4djeD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 6 ILE D 281
GLY D 280
ALA D 263
HIS D 303
 None
 1.00A 1wrqB-4djeD:
undetectable		 1wrqB-4djeD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		5 / 12 ASN D 163
ILE D 298
ALA D 185
LEU D 172
ILE D 211
 None
 1.12A 2h42B-4djeD:
undetectable		 2h42B-4djeD:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		6 / 12 LEU D 147
ASP D 143
GLY D 138
ASP D 106
VAL D 150
VAL D 146
 None
 1.24A 2nnkB-4djeD:
undetectable		 2nnkB-4djeD:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		5 / 12 ALA D 308
ALA D 306
GLY D  57
GLY D  94
LEU D  97
 None
 0.90A 2x1lB-4djeD:
undetectable		 2x1lB-4djeD:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 5 ILE D 193
SER D 187
PRO D 188
PRO D 215
 None
 1.34A 3bjwC-4djeD:
undetectable		 3bjwC-4djeD:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 5 ILE D 217
SER D 216
PRO D 215
PRO D 188
 None
 1.30A 3bjwC-4djeD:
undetectable		 3bjwC-4djeD:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		5 / 12 ILE D 213
VAL D 249
ILE D 250
ILE D 184
PRO D 215
 None
 0.91A 3kpbA-4djeD:
undetectable		 3kpbA-4djeD:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		5 / 12 ILE D 213
VAL D 249
ILE D 250
ILE D 184
PRO D 215
 None
 0.95A 3kpbC-4djeD:
undetectable		 3kpbC-4djeD:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		5 / 11 ALA D 151
ALA D 153
ALA D 154
VAL D 124
LEU D 100
 None
 1.12A 4j6cA-4djeD:
undetectable		 4j6cA-4djeD:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		5 / 10 ALA D 151
ALA D 153
ALA D 154
VAL D 124
LEU D 100
 None
 1.12A 4j6cB-4djeD:
undetectable		 4j6cB-4djeD:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		5 / 9 THR D 287
ALA D 296
GLY D 219
GLY D 218
ASP D 214
 None
 1.13A 4qwuK-4djeD:
undetectable
4qwuL-4djeD:
undetectable		 4qwuK-4djeD:
19.08
4qwuL-4djeD:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		5 / 9 THR D 287
ALA D 296
GLY D 219
GLY D 218
ASP D 214
 None
 1.08A 4qwuY-4djeD:
undetectable
4qwuZ-4djeD:
undetectable		 4qwuY-4djeD:
19.08
4qwuZ-4djeD:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		5 / 11 ALA D 290
THR D 289
ALA D 288
GLY D 295
ALA D 294
 None
 0.99A 5lf3K-4djeD:
undetectable
5lf3L-4djeD:
undetectable		 5lf3K-4djeD:
18.84
5lf3L-4djeD:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		5 / 11 ALA D 290
THR D 289
ALA D 288
GLY D 295
ALA D 294
 None
 0.99A 5lf3Y-4djeD:
undetectable
5lf3Z-4djeD:
undetectable		 5lf3Y-4djeD:
18.84
5lf3Z-4djeD:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT
(Moorella
thermoacetica) 		4 / 4 HIS D 181
VAL D 134
LEU D 159
ALA D 151
 None
 1.25A 6d8pB-4djeD:
2.3		 6d8pB-4djeD:
17.10