SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4djt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		5 / 12 ALA A 152
ILE A 150
VAL A  18
LEU A  99
ILE A 131
 GDP  A 301 (-3.7A)
None
GDP  A 301 (-3.9A)
None
None
 1.04A 1xozA-4djtA:
undetectable		 1xozA-4djtA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		3 / 3 TRP A 102
THR A  64
TYR A  77
 None
 1.12A 2a3aA-4djtA:
undetectable		 2a3aA-4djtA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		3 / 3 TRP A 102
THR A  64
TYR A  77
 None
 1.17A 2a3aB-4djtA:
undetectable		 2a3aB-4djtA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		3 / 3 TRP A 102
THR A  64
TYR A  77
 None
 1.15A 2a3bA-4djtA:
undetectable		 2a3bA-4djtA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		5 / 10 TYR A 147
PHE A  88
LEU A 140
VAL A 139
LEU A  99
 None
 1.28A 2w98A-4djtA:
2.6		 2w98A-4djtA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		5 / 11 ALA A 166
PHE A 162
PHE A 158
ILE A  57
ARG A  26
 None
 1.35A 3n23A-4djtA:
undetectable		 3n23A-4djtA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		4 / 7 ILE A  85
PHE A  49
GLY A 159
LEU A 183
 None
 0.86A 4ze3A-4djtA:
undetectable		 4ze3A-4djtA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		4 / 8 ILE A  85
PHE A  49
GLY A 159
LEU A 183
 None
 0.88A 5esjA-4djtA:
undetectable		 5esjA-4djtA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		4 / 8 ASP A  63
LEU A  12
THR A  64
VAL A  18
 MG  A 302 ( 4.0A)
None
None
GDP  A 301 (-3.9A)
 1.30A 5ov9B-4djtA:
undetectable		 5ov9B-4djtA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		4 / 8 PHE A  59
ILE A  10
PHE A 169
PRO A 115
 None
 0.70A 5x23A-4djtA:
undetectable		 5x23A-4djtA:
17.30