SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4dk1 PUTATIVE MACA,
MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa;
Aggregatibacter
actinomycetemcom
itans) 		4 / 7 GLY A 208
ASP A 228
ILE A 249
VAL A 211
 None
 0.84A 3fi0E-4dk1A:
undetectable		 3fi0E-4dk1A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 4dk1 PUTATIVE MACA,
MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa;
Aggregatibacter
actinomycetemcom
itans) 		5 / 12 GLY A 261
GLY A  50
GLU A 196
VAL A 211
ILE A 249
 None
 0.74A 3p97C-4dk1A:
undetectable		 3p97C-4dk1A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4dk1 PUTATIVE MACA,
MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa;
Aggregatibacter
actinomycetemcom
itans) 		5 / 12 ALA A 186
GLY A 160
HIS A 256
ASP A  59
SER A  54
 None
 1.31A 3pfgA-4dk1A:
undetectable		 3pfgA-4dk1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4dk1 PUTATIVE MACA,
MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa;
Aggregatibacter
actinomycetemcom
itans) 		4 / 8 ILE A 227
ASP A 228
ILE A 249
GLY A  50
 None
 0.79A 4acaC-4dk1A:
3.8		 4acaC-4dk1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4dk1 PUTATIVE MACA,
MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa;
Aggregatibacter
actinomycetemcom
itans) 		4 / 8 ILE A 227
ASP A 228
ILE A 249
GLY A  50
 None
 0.75A 4acbC-4dk1A:
3.9		 4acbC-4dk1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4dk1 PUTATIVE MACA,
MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa;
Aggregatibacter
actinomycetemcom
itans) 		5 / 12 GLY A 261
GLY A  50
GLU A 196
VAL A 211
ILE A 249
 None
 0.83A 4ctjA-4dk1A:
undetectable		 4ctjA-4dk1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4dk1 PUTATIVE MACA,
MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa;
Aggregatibacter
actinomycetemcom
itans) 		5 / 12 GLY A 261
GLY A  50
GLU A 196
VAL A 211
ILE A 249
 None
 0.77A 5ec8C-4dk1A:
undetectable		 5ec8C-4dk1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 4dk1 PUTATIVE MACA,
MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa;
Aggregatibacter
actinomycetemcom
itans) 		5 / 12 GLY A 261
GLY A  50
GLU A 196
VAL A 211
ILE A 249
 None
 0.78A 5ekxB-4dk1A:
undetectable		 5ekxB-4dk1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4dk1 PUTATIVE MACA,
MULTIDRUG RESISTANCE
PROTEIN MEXA
(Pseudomonas
aeruginosa;
Aggregatibacter
actinomycetemcom
itans) 		3 / 3 ALA A 145
ASN A 148
LEU A 149
 None
 0.47A 5i1oA-4dk1A:
undetectable		 5i1oA-4dk1A:
7.49