SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dka'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 12 ALA A  24
SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
 None
 1.47A 3qxtA-4dkaA:
22.6		 3qxtA-4dkaA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 12 VAL A   2
ALA A  24
MET A  34
ARG A  72
ASN A  77
ALA A  98
 None
 0.95A 3qxtA-4dkaA:
22.6		 3qxtA-4dkaA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 12 VAL A   2
ALA A  24
MET A  34
ARG A  72
VAL A  79
ALA A  98
 None
 0.83A 3qxtA-4dkaA:
22.6		 3qxtA-4dkaA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		7 / 12 LEU A   4
ALA A  24
SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
 None
 1.25A 3qxtB-4dkaA:
22.4		 3qxtB-4dkaA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		8 / 12 VAL A   2
LEU A   4
ALA A  24
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 116
 None
 0.72A 3qxtB-4dkaA:
22.4		 3qxtB-4dkaA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		7 / 12 ALA A  24
MET A  34
ARG A  72
ASN A  74
VAL A  79
ALA A  98
TYR A 116
 None
 0.69A 3qxvA-4dkaA:
22.1		 3qxvA-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		7 / 12 ALA A  24
SER A  30
MET A  34
ARG A  72
ASN A  74
VAL A  79
ALA A  98
 None
 1.24A 3qxvA-4dkaA:
22.1		 3qxvA-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		7 / 12 VAL A   2
ALA A  24
MET A  34
ARG A  72
ASN A  74
VAL A  79
TYR A 116
 None
 0.91A 3qxvA-4dkaA:
22.1		 3qxvA-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 12 ALA A  24
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 116
 None
 0.75A 3qxvB-4dkaA:
22.0		 3qxvB-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 12 ALA A  24
SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
 None
 1.39A 3qxvB-4dkaA:
22.0		 3qxvB-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 11 ALA A  24
MET A  34
ARG A  72
ASN A  74
VAL A  79
ALA A  98
 None
 0.78A 3qxvC-4dkaA:
22.3		 3qxvC-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		7 / 12 VAL A   2
ALA A  24
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 116
 None
 0.81A 3qxvD-4dkaA:
22.0		 3qxvD-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 12 ALA A  24
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 116
 None
 0.76A 3qxvE-4dkaA:
18.4		 3qxvE-4dkaA:
73.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		4 / 7 ALA A  92
THR A  91
VAL A 123
GLU A  89
 None
 0.75A 5ecmD-4dkaA:
undetectable		 5ecmD-4dkaA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dka RNA-EDITING COMPLEX
PROTEIN MP81
SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama;
Trypanosoma
brucei) 		3 / 3 VAL C 736
LEU A  81
MET A  83
 None
 0.68A 5ikrA-4dkaC:
undetectable		 5ikrA-4dkaC:
12.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4dka SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		3 / 3 TYR A  60
GLY A  66
THR A  69
 None
 0.11A 6cjkB-4dkaA:
18.3		 6cjkB-4dkaA:
35.05