SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dkb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 LYS A 208
ASP A  69
ASN A 235
 DUN  A 303 (-2.5A)
None
DUN  A 303 (-3.9A)
 0.98A 2bm9A-4dkbA:
undetectable		 2bm9A-4dkbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		5 / 11 LEU A 238
ASN A 235
ARG A 215
TYR A 225
VAL A 232
 None
DUN  A 303 (-3.9A)
DUN  A 303 (-2.8A)
None
None
 1.15A 2bxgA-4dkbA:
2.4		 2bxgA-4dkbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		4 / 6 LEU A  77
THR A  78
PHE A 199
ASP A 196
 None
 1.01A 2wm3A-4dkbA:
undetectable		 2wm3A-4dkbA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		4 / 8 LEU A  52
THR A  78
ALA A 193
ALA A 194
 None
 1.02A 3ax9B-4dkbA:
undetectable		 3ax9B-4dkbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		5 / 9 GLN A 184
ALA A  88
LEU A 201
VAL A 202
ILE A 191
 None
 0.99A 3claA-4dkbA:
undetectable		 3claA-4dkbA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		5 / 12 ASP A 163
LEU A  70
ILE A 197
PHE A 158
PHE A 171
 None
 1.35A 3ko0G-4dkbA:
undetectable
3ko0H-4dkbA:
undetectable
3ko0I-4dkbA:
undetectable
3ko0J-4dkbA:
undetectable		 3ko0G-4dkbA:
14.73
3ko0H-4dkbA:
14.73
3ko0I-4dkbA:
14.73
3ko0J-4dkbA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		5 / 12 ALA A 194
LEU A  81
ILE A  13
LEU A  17
LEU A 247
 None
 1.06A 4j24D-4dkbA:
undetectable		 4j24D-4dkbA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		5 / 10 LEU A 238
HIS A 209
ALA A 207
HIS A  82
LEU A  24
 None
None
None
DUN  A 303 (-3.7A)
DUN  A 303 (-4.3A)
 1.09A 4p65A-4dkbA:
undetectable
4p65B-4dkbA:
undetectable
4p65F-4dkbA:
undetectable
4p65H-4dkbA:
undetectable		 4p65A-4dkbA:
5.04
4p65B-4dkbA:
7.53
4p65F-4dkbA:
7.53
4p65H-4dkbA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		6 / 11 LEU A 238
HIS A 209
LEU A 211
ALA A 207
HIS A  82
LEU A  24
 None
None
None
None
DUN  A 303 (-3.7A)
DUN  A 303 (-4.3A)
 1.40A 4p65C-4dkbA:
undetectable
4p65D-4dkbA:
undetectable
4p65J-4dkbA:
undetectable
4p65L-4dkbA:
undetectable		 4p65C-4dkbA:
5.04
4p65D-4dkbA:
7.53
4p65J-4dkbA:
7.53
4p65L-4dkbA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		5 / 11 LEU A 238
HIS A 209
ALA A 207
HIS A  82
LEU A  24
 None
None
None
DUN  A 303 (-3.7A)
DUN  A 303 (-4.3A)
 1.08A 4p65E-4dkbA:
undetectable
4p65F-4dkbA:
undetectable
4p65J-4dkbA:
undetectable
4p65L-4dkbA:
undetectable		 4p65E-4dkbA:
5.04
4p65F-4dkbA:
7.53
4p65J-4dkbA:
7.53
4p65L-4dkbA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		4 / 6 HIS A  82
HIS A 209
VAL A 206
LEU A  17
 DUN  A 303 (-3.7A)
None
None
None
 1.26A 5ogjB-4dkbA:
undetectable		 5ogjB-4dkbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		4 / 5 HIS A  82
HIS A 209
VAL A 206
LEU A  17
 DUN  A 303 (-3.7A)
None
None
None
 1.25A 5ohhA-4dkbA:
undetectable		 5ohhA-4dkbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4dkb DEOXYURIDINE
TRIPHOSPHATASE
(Trypanosoma
brucei) 		4 / 6 PRO A 274
ILE A 214
GLY A 272
TYR A 268
 None
 1.11A 6gqiA-4dkbA:
undetectable		 6gqiA-4dkbA:
20.35