SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4dkd INTERLEUKIN-34
(Homo
sapiens) 		3 / 3 LYS A  32
GLU A  34
TRP A 188
 None
 1.41A 3v4tH-4dkdA:
undetectable		 3v4tH-4dkdA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4dkd INTERLEUKIN-34
(Homo
sapiens) 		4 / 7 GLU A 173
TYR A 176
GLY A  39
ARG A  42
 None
 1.02A 4fgzA-4dkdA:
undetectable		 4fgzA-4dkdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4dkd INTERLEUKIN-34
(Homo
sapiens) 		4 / 8 GLU A 173
TYR A 176
GLY A  39
ARG A  42
 None
 1.00A 4fgzA-4dkdA:
undetectable
4fgzB-4dkdA:
undetectable		 4fgzA-4dkdA:
19.63
4fgzB-4dkdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4dkd INTERLEUKIN-34
(Homo
sapiens) 		4 / 6 PHE A  72
ARG A  79
THR A  78
ILE A  74
 NAG  A 301 (-4.5A)
NAG  A 301 (-3.3A)
None
None
 1.22A 5ih0A-4dkdA:
undetectable		 5ih0A-4dkdA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 4dkd INTERLEUKIN-34
(Homo
sapiens) 		5 / 11 ASN A 155
VAL A 105
SER A 104
ASP A 107
LEU A 165
 None
 1.16A 5jh7B-4dkdA:
undetectable		 5jh7B-4dkdA:
19.24